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Mashup Score: 1
Selpercatinib showed clinically meaningful activity in the RET fusion-positive tumour-agnostic population, with a safety profile consistent with that observed in other indications. Comprehensive genomic testing that includes RET fusions will be crucial for identifying patients who might benefit from selpercatinib.
Source: The Lancet OncologyCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Temporally restricted activation of IFNβ signaling underlies response to immune checkpoint therapy in mice - 2 year(s) ago
The biological determinants of the response to immune checkpoint blockade (ICB) in cancer remain incompletely understood. Little is known about dynamic biological events that underpin therapeutic efficacy due to the inability to frequently sample tumours in patients. Here, we map the transcriptional profiles of 144 responding and non-responding tumours within two mouse models at four time points…
Source: www.nature.comCategories: Latest Headlines, Oncologists2Tweet-
1/3 Just out in @NatureComms https://t.co/XPPyuDPFzK Temporally restricted activation of IFNβ signaling underlies response to immune checkpoint therapy in mice. Using mouse models to map the transcriptional profiles of responding and non responding #tumours in two mouse models
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Mashup Score: 0
Since its first proposal in the treatment of pituitary tumours more than a century ago, indications for cranial radiotherapy have notably evolved. In rare pituitary carcinomas, indication of radiotherapy remains undisputable after surgical treatment in case of remnant tumour or recurrence. Until the availability of effective medical treatment, radiotherapy was the second-line treatment for many…
Categories: Endocrinology, Latest HeadlinesTweet-
Luigi Maione & Philippe Chanson comment: Second #brain #tumours after #pituitary #irradiation: lower risk than once thought https://t.co/5l227CQmD6 #FREE to read with registration (also FREE) https://t.co/Odol29Li7n
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Mashup Score: 1
Since its first proposal in the treatment of pituitary tumours more than a century ago, indications for cranial radiotherapy have notably evolved. In rare pituitary carcinomas, indication of radiotherapy remains undisputable after surgical treatment in case of remnant tumour or recurrence. Until the availability of effective medical treatment, radiotherapy was the second-line treatment for many…
Categories: Endocrinology, Latest HeadlinesTweet-
Luigi Maione & Philippe Chanson comment: Second #brain #tumours after #pituitary #irradiation: lower risk than once thought https://t.co/5l227CQmD6 #FREE to read with registration (also FREE) https://t.co/1zvZYC0qUj
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Mashup Score: 0
Since its first proposal in the treatment of pituitary tumours more than a century ago, indications for cranial radiotherapy have notably evolved. In rare pituitary carcinomas, indication of radiotherapy remains undisputable after surgical treatment in case of remnant tumour or recurrence. Until the availability of effective medical treatment, radiotherapy was the second-line treatment for many…
Categories: Endocrinology, Latest HeadlinesTweet-
Comment by Luigi Maione & Philippe Chanson: Second #brain #tumours after #pituitary #irradiation: lower risk than once thought https://t.co/5l227CQmD6 #FREE to read with registration (also FREE) https://t.co/uSdE6YRTqK
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Mashup Score: 0Nature Reviews Cancer - Volume 22 Issue 8, August 2022 - 2 year(s) ago
COVER: Unplugging connections, inspired by the Review on p481.
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Our Aug issue, out NOW! With articles on nonsense-mediated RNA decay, diet interventions as #therapy ,#polyamines & disconnecting multicellular networks in brain #tumours! Plus, a World View on what cancer survivors can teach researchers. 💌 https://t.co/NC4SWI4iv9 @natrescancer https://t.co/LjSYiLYQNK
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Mashup Score: 0
Since its first proposal in the treatment of pituitary tumours more than a century ago, indications for cranial radiotherapy have notably evolved. In rare pituitary carcinomas, indication of radiotherapy remains undisputable after surgical treatment in case of remnant tumour or recurrence. Until the availability of effective medical treatment, radiotherapy was the second-line treatment for many…
Categories: Endocrinology, Latest HeadlinesTweet-
Luigi Maione & Philippe Chanson comment: Second #brain #tumours after #pituitary #irradiation: lower risk than once thought https://t.co/5l227CQmD6 #FREE to read with registration (also FREE)
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Mashup Score: 0
Since its first proposal in the treatment of pituitary tumours more than a century ago, indications for cranial radiotherapy have notably evolved. In rare pituitary carcinomas, indication of radiotherapy remains undisputable after surgical treatment in case of remnant tumour or recurrence. Until the availability of effective medical treatment, radiotherapy was the second-line treatment for many…
Categories: Endocrinology, Latest HeadlinesTweet-
Also read the Linked Comment: Second #brain #tumours after #pituitary #irradiation: lower risk than once thought https://t.co/5l227CQmD6 #FREE to read with registration (also FREE)
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Mashup Score: 2The Lancet Diabetes & Endocrinology, August 2022, Volume 10, Issue 8, Pages 549-608, e8 - 2 year(s) ago
Explore the current issue of The Lancet Diabetes & Endocrinology, a monthly journal focussed on diabetes, endocrinology, and metabolism
Source: www.thelancet.comCategories: Endocrinology, Latest HeadlinesTweet-
The August Issue of @TheLancetEndo is now online, featuring #brain #tumours, #radiotherapy, #COVID19, #vaccines, #diabetes, #BMI, #obesity, #T1D, #autoantibodies, #screening, #Genetics, #NCDs, #JunkFood ads, #insulin, #glycaemic management & more https://t.co/ft8CFDeSQz https://t.co/Q22sbeJ698
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Mashup Score: 4The impact of rare germline variants on human somatic mutation processes - Nature Communications - 2 year(s) ago
The impact of germline variants on somatic alterations in cancer remains to be explored in large-scale datasets. Here, the authors study the association of rare germline variants with somatic mutational processes in more than 15,000 tumors, and reveal that damaging variants in newly-identifed genes are prevalent in the population.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Study of rare #germline variants in more than 15,000 #tumours reveals their impact on #somatic mutational processes and their prevalence in the population #CancerResearch by @Mischan11 @FranSupek @BenLehner @CRGenomica @IRBBarcelona @natrescancer https://t.co/LTKLi1NCQt https://t.co/9LQhNOobbq
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Online first: LIBRETTO-001 - Tumour-agnostic efficacy and safety of #selpercatinib in patients with RET fusion-positive solid #tumours other than lung or thyroid tumours: a phase 1/2, open-label, basket trial https://t.co/HAjMVZi26J https://t.co/6voW44hb9X