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Mashup Score: 1Effects of dapagliflozin on hospitalisations in people with type 2 diabetes: post-hoc analyses of the DECLARE-TIMI 58 trial - 2 year(s) ago
Dapagliflozin reduced the risk of first and total non-elective hospitalisations for any cause in people with type 2 diabetes, regardless of the presence of atherosclerotic cardiovascular disease, including hospitalisations not directly attributed to cardiac, kidney, or metabolic causes. These findings might have implications on health-related quality of life for people with type 2 diabetes and on…
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Mashup Score: 0The growing clinical effect of SGLT2 inhibitors - 2 year(s) ago
In September, 2015, the results of EMPA-REG OUTCOME, the first cardiovascular outcomes study based on a sodium-glucose co-transporter-2 (SGLT2) inhibitor, empagliflozin, were announced at the Annual Meeting of the European Association for the Study of Diabetes. It was the first of a series of cardiovascular outcome studies confirming a significant risk reduction of the three-point MACE…
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Stefano Del Prato comments on: The growing clinical effect of #SGLT2 inhibitors https://t.co/ZAqKZGPXH7 #T2D
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Mashup Score: 3BMI versus obesity subtypes in the era of precision medicine - 2 year(s) ago
The current epidemic of obesity represents a huge challenge to public health authorities and clinical practice. Typically defined by a BMI of 30 kg/m2 or more, obesity is associated with increased morbidity and mortality.1 Although BMI has been useful for monitoring rapid growth in the prevalence of obesity and its association with chronic conditions,1 there can be considerable variation in the…
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Read our new Comment: "BMI versus obesity subtypes in the era of precision medicine". Jean-Pierre Després discusses the differentiation of categories of obesity and what that means for management. https://t.co/bkoR5lTDht #obesity #precisionmedicine #BMI
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Mashup Score: 29Lancet Diabetes & Endocrinology Commission on the Definition and Diagnosis of Clinical Obesity - 2 year(s) ago
Obesity was first recognised as a disease by WHO in 1948, then between 2013 and 2022 by several medical societies and countries.1–8 However, the notion that obesity is a disease and not merely a risk factor for other illnesses remains highly controversial, both within and beyond medical circles. This debate constitutes far more than arcane semantics, and seriously affects the provision of…
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RT @CristobMorales: https://t.co/noxsKKmc5D Commission on the Definition and Diagnosis of Clinical Obesity @TheLancetEndo @SociedadSeedo @A…
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Mashup Score: 0Challenging diabetes stigma starts and ends with all of us - 2 year(s) ago
There is an entrenched, inaccurate, and overly simplistic, societal view that diabetes is caused by a failure of personal responsibility.1 This negative social judgement, known as diabetes stigma, can lead to perceived or experienced blame, stereotyping, rejection, exclusion, or discrimination (figure). In 2011, the International Diabetes Federation called for global action to challenge social…
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Online first—Challenging #diabetes #stigma starts and ends with all of us https://t.co/AotBi1MlQp #T1D #T2D
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Mashup Score: 10Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis - 2 year(s) ago
Hyperthyroidism is a common condition with a global prevalence of 0·2–1·3%. When clinical suspicion of hyperthyroidism arises, it should be confirmed by biochemical tests (eg, low TSH, high free thyroxine [FT4], or high free tri-iodothyonine [FT3]). If hyperthyroidism is confirmed by biochemical tests, a nosological diagnosis should be done to find out which disease is causing the…
Categories: Hem/Oncs, Latest HeadlinesTweet-
RT @TheLancetEndo: #Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis https://t.co/YyILhYb7mu #…
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Mashup Score: 1
These findings do not support concerns that bolus doses of vitamin D administered monthly increase fracture risk. Long-term supplementation might reduce the incidence of total fractures, but additional research is needed to clarify this effect.
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The effect of monthly #vitamin D supplementation on #fractures: a tertiary outcome from the population-based, double-blind, randomised, placebo-controlled D-Health trial https://t.co/RpDGOfOSSX #vitaminD #osteoporosis #BMD
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Mashup Score: 0Vitamin D and fractures - 2 year(s) ago
Vitamin D was identified in the 1920s as the active principal in cod liver oil’s capacity to cure nutritional rickets. Since then, vitamin D has been regarded as a bone tonic by some; although, the prevention and cure of rickets and osteomalacia remain the only undisputed medical use of vitamin D. Also undisputed is that 1,25-dihydroxyvitamin D, a metabolite of vitamin D, is a potent regulator of…
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Ian R Reid comments on: Vitamin D and fractures https://t.co/kDCOapi6nO #vitaminD #fractures #osteoporosis #BMD
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Mashup Score: 0
Tackling the mechanisms underlying ageing is desirable to help to extend the duration and improve the quality of life. Life extension has been achieved in animal models by suppressing the growth hormone–insulin-like growth factor 1 (IGF-1) axis and also via dietary restriction. Metformin has become the focus of increased interest as a possible anti-ageing drug. There is some overlap in the…
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Mechanisms of #ageing: growth hormone, dietary restriction, and metformin https://t.co/v3xVZPA1I0 #aging #antiaging #metformin #GrowthHormone #DietaryRestriction
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Mashup Score: 1Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis - 2 year(s) ago
Hyperthyroidism is a common condition with a global prevalence of 0·2–1·3%. When clinical suspicion of hyperthyroidism arises, it should be confirmed by biochemical tests (eg, low TSH, high free thyroxine [FT4], or high free tri-iodothyonine [FT3]). If hyperthyroidism is confirmed by biochemical tests, a nosological diagnosis should be done to find out which disease is causing the…
Categories: Endocrinology, Latest HeadlinesTweet-
#Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis https://t.co/YyILhYb7mu #thyroid
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Effects of #dapagliflozin on #hospitalisations in people with type 2 #diabetes: post-hoc analyses of the DECLARE-TIMI 58 trial https://t.co/4OOalOalfR #T2D