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Mashup Score: 0Glucose intolerance in pregnancy and risk of early-onset type 2 diabetes: a population-based cohort study - 1 year(s) ago
Gestational glucose intolerance, including conditions not meeting gestational diabetes criteria of the two-step strategy, confers a high risk of type 2 diabetes in young adulthood. These conditions should be recognised as risk factors for type 2 diabetes, especially among women with abnormal fasting glucose concentrations during pregnancy.
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Mashup Score: 0Defining gestational diabetes: not just about cutoffs - 1 year(s) ago
The criteria for diagnosing gestational diabetes, defined as hyperglycaemia less than overt diabetes first detected in pregnancy,1 vary globally. The International Association of Diabetes in Pregnancy Study Groups (IADPSG), informed by the large international Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study (n=25 505),2 sought diagnostic consensus in 2010.1 A global oral glucose…
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Linked Comment: Defining #gestational #diabetes: not just about cutoffs https://t.co/SlrswK3Oky #GDM #T2D
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Mashup Score: 2Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants - 1 year(s) ago
Patients with germline SDHD pathogenic variants (encoding succinate dehydrogenase subunit D; ie, paraganglioma 1 syndrome) are predominantly affected by head and neck paragangliomas, which, in almost 20% of patients, might coexist with paragangliomas arising from other locations (eg, adrenal medulla, para-aortic, cardiac or thoracic, and pelvic). Given the higher risk of tumour multifocality and…
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Clinical consensus guideline on the management of #phaeochromocytoma and #paraganglioma in patients harbouring germline #SDHD pathogenic variants https://t.co/PJSiZnUXga #FREE to read with registration (also FREE) https://t.co/WJA5ZGsK8d
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Mashup Score: 0Molecular basis of normal and pathological puberty: from basic mechanisms to clinical implications - 1 year(s) ago
Puberty is a major maturational event; its mechanisms and timing are driven by genetic determinants, but also controlled by endogenous and environmental cues. Substantial progress towards elucidation of the neuroendocrine networks governing puberty has taken place. However, key aspects of the mechanisms responsible for the precise timing of puberty and its alterations have only recently begun to…
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The progress in our understanding of the mechanisms controlling #puberty is a success story in modern #neuroendocrinology https://t.co/nynT2gWjyN #neuroendocrine #kisspeptins https://t.co/DG9G76bL61
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Mashup Score: 4
Few people now reach old age without taking multiple drugs, often attending various clinics, and undergoing secondary or tertiary investigations. Most chronic conditions are, to differing extents, caused or exacerbated by excess adiposity, but weight management is rarely discussed or attempted for patients. Furthermore, progressive symptoms usually attributed to ageing (eg, musculoskeletal pains,…
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Treating chronic diseases without tackling excess #adiposity promotes #multimorbidity https://t.co/C8qk1IHkeO #obesity #NCDs #publichealth https://t.co/bymLaiMAba
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Mashup Score: 0Glucose-lowering drugs with cardiovascular benefits as modifiers of critical elements of the human life history - 1 year(s) ago
The life history theory assumes that all organisms are under selective pressure to harvest external resources and allocate them to maximise fitness: only organisms making the best use of energy obtain the greatest fitness benefits. The trade-off of energy spans four functions: maintenance, growth, reproduction, and defence against pathogens. The innovative antihyperglycaemic agents glucagon-like…
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#Glucose-lowering #drugs with #cardiovascular benefits as modifiers of critical elements of the human life history https://t.co/FdnQia6pVL #diabetes #obesity #GLP-1 receptor agonists #SGLT2 inhibitors https://t.co/hX7xpHmlkY
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Mashup Score: 4Continuous glucose monitoring and metrics for clinical trials: an international consensus statement - 1 year(s) ago
Randomised controlled trials and other prospective clinical studies for novel medical interventions in people with diabetes have traditionally reported HbA1c as the measure of average blood glucose levels for the 3 months preceding the HbA1c test date. The use of this measure highlights the long-established correlation between HbA1c and relative risk of diabetes complications; the change in the…
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Continuous glucose monitoring and metrics for clinical trials: an international consensus statement https://t.co/hrNXB9yKgy #CGM #diabetes #FREE to read with registration (also FREE)
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Mashup Score: 1
2022 corresponds to the 100th anniversary of the discovery of glucagon. This TimeCapsule aims to recall the main steps leading to the discovery, characterisation, and clinical importance of the so-called second pancreatic hormone. We describe the early historical findings in basic research (ie, discovery, purification, structure, α-cell origin, radioimmunoassay, glucagon gene [GCG], and glucagon…
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#Glucagon, from past to present: a century of intensive research and controversies https://t.co/FfFclfQszb #diabetes #obesity #FREE to read with registration (also FREE) https://t.co/wWkl0RRab4
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Mashup Score: 5A global view of the interplay between non-alcoholic fatty liver disease and diabetes - 1 year(s) ago
Non-alcoholic fatty liver disease (NAFLD) has become an epidemic, much like other non-communicable diseases (NCDs), such as cancer, obesity, diabetes, and cardiovascular disease. The pathophysiology of NAFLD, particularly involving insulin resistance and subclinical inflammation, is not only closely linked to that of those NCDs but also to a severe course of the communicable disease COVID-19….
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A global view of the interplay between non-alcoholic fatty #liver disease and #diabetes https://t.co/YHABg4OCfj #NAFLD #T2D https://t.co/3fol3Gh8vo
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Mashup Score: 0Effective, disease-modifying, clinical approaches to patients with mild-to-moderate hypertriglyceridaemia - 1 year(s) ago
Plasma triglyceride concentration is easily, inexpensively, and accurately measured, and when elevated is a highly informative disease marker that identifies individuals who frequently have a host of underlying metabolic, inflammatory, and atherogenic risk factors. Although this concept aligns with much that has been discussed regarding the metabolic syndrome, individuals identified with…
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Effective, disease-modifying, clinical approaches to patients with mild-to-moderate #hypertriglyceridaemia https://t.co/LHnhsqahW9 #triglycerides #lipids #ASCVD https://t.co/Wm4LDJAhrQ
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#Glucose intolerance in #pregnancy and risk of early-onset type 2 #diabetes: a population-based cohort study https://t.co/qO2ZXoOkAQ #GDM #gestational #diabetes #T2D