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Mashup Score: 1Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light - 2 year(s) ago
Background and Objectives To evaluate whether plasma biomarkers of amyloid (Aβ42/Aβ40), tau (p-tau181 and p-tau231), and neuroaxonal injury (neurofilament light chain [NfL]) detect brain amyloidosis consistently across racial groups. Methods Individuals enrolled in studies of memory and aging who self-identified as African American (AA) were matched 1:1 to self-identified non-Hispanic White…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet
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Mashup Score: 14Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model - 3 year(s) ago
Wild-type human recombinant tau protein infused in presynaptic terminals newly assembled microtubules, which sequestered cytosolic dynamins, thereby blocking synaptic vesicle endocytosis and causing activity-dependent rundown of excitatory synaptic transmission in a slice model of mouse brainstem.
Source: eLifeCategories: General Medicine News, Latest HeadlinesTweet-
Untangling the role of #tau in Alzheimer's disease @elife https://t.co/m1j4suU5eL https://t.co/Jcq8f9oVhm
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Mashup Score: 1Fluent molecular mixing of Tau isoforms in Alzheimer’s disease neurofibrillary tangles - Nature Communications - 3 year(s) ago
The tau protein in Alzheimer’s disease contains two isoforms. Using solid-state NMR and seeded growth of isotopically labeled tau, here the authors determined that the two isoforms mix fluently on the molecular level to propagate the AD tau structure.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Using solid-state NMR and seeded growth of isotopically labeled tau, the researchers from @MeiHongLab determined that the two isoforms mix fluently on the molecular level to propagate the AD tau structure. #tau #fibrils https://t.co/vhkWrafT5J https://t.co/mSHthI1Flp
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Mashup Score: 10
This Viewpoint discusses issues surrounding the release of biomarker measures by research studies to their participants.
Source: jamanetwork.comCategories: Healthcare Professionals, Latest HeadlinesTweet-
Disclosing #Alzheimer Disease #Biomarker Results to Research Participants https://t.co/57IYpRSifd via @JAMANeuro #ethics "Returning #Alzheimerdisease biomarker results to individuals with #MCI and #dementia is (clinical) care. #tauPET #amyloidPET #amyloid #tau
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Mashup Score: 2Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses - Nature Communications - 3 year(s) ago
In this work, the authors report that hyperphosphorylated recombinant tau spontaneously assembles into small, amorphous aggregates, which disrupt membranes and induce Toll-like receptor 4-dependent responses in human macrophages.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
The @KlenermanLab reports spontaneous assembly of hyperphosphorylated recombinant tau into small, amorphous aggregates, which disrupt membranes and induce TLR4-dependent responses in human macrophages. @JonathanXMeng2, @YZCam81, @UKDRICam #tau https://t.co/gjUdjKMEZ8 https://t.co/2Nz0uSQGD1
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Mashup Score: 1Alzheimer’s Brain Barrier Damage Theory Could Pave Way for New Treatments - Neuroscience News - 3 year(s) ago
Lipids entering the brain as a result of damage to the blood-brain barrier may be a determining cause of Alzheimer’s disease. Researchers say simple lifestyle changes could reduce Alzheimer’s risks by reducing the impact on the BBB and decrease Alzheimer’s associated brain damage.
Source: Neuroscience NewsCategories: Healthcare Professionals, Latest HeadlinesTweet-
A New Hypothesis for #Alzheimer’s Disease: The “Lipid Invasion Model” https://t.co/Y5meDD6NhB #BBB #BloodBrainBarrier #FattyAcids #Lipoproteins #amyloid #tau #ApoE4
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Mashup Score: 10
“The biggest challenge is finding participants willing to volunteer to be a in a research study. We are at a point with the science where we know that what we are trying to do is scientifically feasible.”
Source: www.mdedge.comCategories: Latest Headlines, PsychiatryTweet-
Increased #tau concentrations in the brain’s frontal, medial and occipital cortices are associated with psychosis and more rapid decline in Alzheimer’s, new imaging study finds. https://t.co/1doPvVeXqE https://t.co/XcbChRrESN
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Mashup Score: 16
Utilizing cutting-edge proteomics, researchers at the Buck Institute and elsewhere have mapped the “tau interactome” uncovering new findings about the role of tau in neurodegenerative disease. Publishing in Cell, scientists found that mutant tau impacts the function of mitochondria in human neurons. They also suggest a mechanism for how tau gets released from neurons and spreads throughout the…
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet-
New findings for the function of #tau in neurodegenerative disease @CellCellPress https://t.co/vqwycGycrC
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Mashup Score: 9
Just as a home security system can alert a homeowner to the presence of an intruder, a protein called polyglutamine binding protein-1 (PQBP1) found in brain cells can alert the body to the presence of “intruding” viruses like human immunodeficiency virus (HIV). Now, researchers in Japan have shed new light on the role of PQBP1 in the detection of dysfunctional proteins associated with…
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet-
#Tau and PQBP1: Protein interaction induces inflammation in the #brain @NatureComms https://t.co/htkLKdE0AK
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Mashup Score: 2
A new study adds additional evidence to the link between personality traits and Alzheimer’s risk. Researchers found brain changes associated with Alzheimer’s are visible early on in people with certain personality traits. Those who scored high for neuroticism and low in conscientiousness were at increased risk of developing Alzheimer’s.
Source: Neuroscience NewsCategories: Healthcare Professionals, Latest HeadlinesTweet-
Personality Traits Linked to Hallmarks of #Alzheimer Disease - #Neuroscience News “#Neuroticism and #conscientiousness may contribute to resistance against #amyloid and #tau neuropathology.” I’m home free.. https://t.co/xeK3M9relK
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This study evaluated whether plasma biomarkers of amyloid (Aβ42/Aβ40), #tau (p-tau181 and p-tau231), and neuroaxonal injury (neurofilament light chain) detect brain amyloidosis consistently across racial groups: https://t.co/g9iZNahMQD #NeuroTwitter #Neurology https://t.co/JripuutCwk