A 59-year-old woman developed severe headache and vomiting. An examination of the brain MRI showed multiple supratentorial gadolinium-enhancing nodular lesions. In addition, fluid attenuated inversion recovery (FLAIR) images showed curvilinear hyperintensity along the pons surface, with a corresponding restricted diffusion, and no contrast enhancement (Figure). Fever or symptoms suggestive of…

Although the assessment of death has long been accepted as the physician’s domain, death as a concept is shared with several stakeholders, including religion, philosophy, and society as a whole. This is not to say that the physician is not part of the conceptual understanding of death, but rather that the physician cannot claim sole ownership of defining death. This claim is illustrated by the…

The Uniform Determination of Death Act (UDDA) defines death by neurologic criteria (i.e., brain death) as “irreversible cessation of all functions of the entire brain, including the brainstem … in accordance with accepted medical standards.”1 The American Academy of Neurology (AAN) and other professional organizations have outlined these best accepted standards,2,3 which at the least involves…

Objective To describe a child meeting diagnostic criteria for tuberous sclerosis complex (TSC) carrying a pathogenic somatic variant in RHEB , but no pathogenic variants in the 2 known TSC genes, TSC1 or TSC2 . Methods We present the clinical and imaging findings in a child presenting with drug-resistant focal seizures and multiple cortical tubers, a subependymal giant cell astrocytoma and…