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Mashup Score: 0
Researchers sought to assess how osteoarthritis and APOE-4 influence the accumulation of Aβ and tau accumulation in the primary motor and somatosensory regions in older adults who are Aβ+.
Source: Neurology AdvisorCategories: Latest Headlines, NeurologyTweet
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Mashup Score: 1A new peptide may hold potential as an Alzheimer’s treatment - 2 year(s) ago
MIT neuroscientists found a way to reverse neurodegeneration and other symptoms of Alzheimer’s disease in mice by using a peptide to interfere with an enzyme that is typically overactive in the brains of Alzheimer’s patients.
Categories: Healthcare Professionals, Latest HeadlinesTweet-
A new peptide may hold potential as an #Alzheimer’s treatment https://t.co/35a7drW0K8 #dementia #neurodegeneration #Cdk5i #tau #BBB A #Cdk5-derived [12-AA] peptide inhibits Cdk5/#p25 activity and improves neurodegenerative phenotypes | PNAS https://t.co/82Ru6NrEjj https://t.co/ElHmfAs0vy
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Mashup Score: 0
17 Mar 2023 Here’s a tau twist that may take some adapting to. CD4+ and CD8+ T cells, yes, those mercurial executioners of the immune system, may be responsible for the neurodegeneration seen in Alzheimer’s disease and other tauopathies. That’s the scenario outlined by David Holtzman, Washington University, St. Louis, and colleagues in Nature on March 8. The scientists report that,…
Source: www.alzforum.orgCategories: Healthcare Professionals, Latest HeadlinesTweet-
#Neurodegeneration—It’s Not the Tangles, It’s the #TCells https://t.co/571GEFzpMZ #microglia #CD8+ #meninges #brain #parenchyma #immunity #PD1 #dementia #amyloid #tau #Aβ Activated immune cells drive neurodegeneration in an #Alzheimer’s model https://t.co/VUaJjzkPk7 Can #AD… https://t.co/UGZigewVsm https://t.co/3BL4qnK4CR
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Mashup Score: 14Tau-RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change - 2 year(s) ago
McMillan et al. show that native tau binds RNA with high affinity but low specificity. Tau/RNA binding drives tau conformational change, inhibits microtubule as
Source: OUP AcademicCategories: General Medicine News, Latest HeadlinesTweet-
Overlooked #tau-#RNA interaction may play key role in dementia https://t.co/3fe6Lg60vw https://t.co/py6TRnLnpb
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Mashup Score: 2Novel Blood Test Detects Alzheimer's Neurodegeneration - 2 year(s) ago
Brain-derived tau distinguished Alzheimer’s from other dementias
Source: www.medpagetoday.comCategories: Healthcare Professionals, Latest HeadlinesTweet-
BREAKTHROUGH: Novel Blood Test Detects #Alzheimer's Neurodegeneration https://t.co/Wql3esuRYk #Dementia #Brain-derived #tau: a novel #blood-based #biomarker for Alzheimer’s disease-type #neurodegeneration https://t.co/ATDJNRoh0v https://t.co/IGbcCUFNSF
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Mashup Score: 14Targeting tau, the other protein behind Alzheimer's disease - 2 year(s) ago
In November, researchers reported the drug lecanemab slowed the progression of Alzheimer’s disease. The effect was modest, but it has generated tremendous excitement because it was the first time a drug had been shown to be able to affect the course of this relentless, incurable disease.
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet-
Targeting #tau, the other protein behind Alzheimer's disease @uwmedicine @PNASNews https://t.co/XUHOuPrjBo
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Mashup Score: 2Chronic pain causes Tau-mediated hippocampal pathology and memory deficits - Molecular Psychiatry - 2 year(s) ago
Persistent pain has been recently suggested as a risk factor for dementia. Indeed, chronic pain is frequently accompanied by maladaptive brain plasticity and cognitive deficits whose molecular underpinnings are poorly understood. Despite the emerging role of Tau as a key regulator of neuronal plasticity and pathology in diverse brain disorders, the role of Tau has never been studied in the…
Source: NatureCategories: Healthcare Professionals, Latest HeadlinesTweet-
#Chronicpain causes #Tau-mediated hippocampal pathology and #memory deficits https://t.co/In8tu0t2sE #neuropathicpain #dementia #cognition Chronic pain inhibits #autophagy in #hippocampus while the analgetic drug, #Gabapentin reverts this SNI-driven action https://t.co/AoJsktzCV3 https://t.co/7BOYBfIbft
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Mashup Score: 14
Martinez et al. identified the protein interactome of the tau seed responsible for propagation. The authors found how the presynaptic protein Bassoon interacts with the tau seed enhancing its stability and subsequently tau toxicity and spreading.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Researchers identify #protein that contributes to #tau neurotoxicity in Alzheimer's disease @iumedschool @NatureNeuro https://t.co/zd9tv5bPxK https://t.co/LIW9vb9uHa
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Mashup Score: 0New Study Calls Into Question Widely-Held Alzheimer’s Beliefs - 2 year(s) ago
The study discovered that as Alzheimer’s disease progresses, brain levels of enzymes that regulate DNA-folding decrease. Researchers from the University of Pittsburgh, McGill University, and Harvard University found that, in contrast to earlier research, the levels of brain enzymes that control DNA
Source: SciTechDailyCategories: Healthcare Professionals, Latest HeadlinesTweet-
New Study Calls Into Question Widely-Held #Alzheimer’s Beliefs - https://t.co/pASz7EO6EA #amyloid #tau [11C]Martinostat PET analysis reveals reduced #HDAC I availability in Alzheimer’s disease https://t.co/fbxjnkEHgz #brain #imaging #epigenetics HDAC inhibitors may be harmful. https://t.co/LIsenWhiUQ
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Mashup Score: 1Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light - 2 year(s) ago
Background and Objectives To evaluate whether plasma biomarkers of amyloid (Aβ42/Aβ40), tau (p-tau181 and p-tau231), and neuroaxonal injury (neurofilament light chain [NfL]) detect brain amyloidosis consistently across racial groups. Methods Individuals enrolled in studies of memory and aging who self-identified as African American (AA) were matched 1:1 to self-identified non-Hispanic White…
Source: NeurologyCategories: Latest Headlines, NeurologyTweet-
This study evaluated whether plasma biomarkers of amyloid (Aβ42/Aβ40), #tau (p-tau181 and p-tau231), and neuroaxonal injury (neurofilament light chain) detect brain amyloidosis consistently across racial groups: https://t.co/g9iZNahMQD #NeuroTwitter #Neurology https://t.co/JripuutCwk
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An association exists between osteoarthritis and faster #betaamyloid (Aβ) accumulation and higher Aβ-dependent future #tau deposition. #AlzheimersandBrainAwarenessMonth #NeuroTwitter https://t.co/vpN4aKCLgM