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Mashup Score: 0Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension. | ALZFORUM - 4 month(s) ago
Santisteban MM, Schaeffer S, Anfray A, Faraco G, Brea D, Wang G, Sobanko MJ, Sciortino R, Racchumi G, Waisman A, Park L, Anrather J, Iadecola C.. Nat Neurosci. 2023 Dec 4; PubMed. Please login to recommend the
Source: www.alzforum.orgCategories: General Medicine News, General HCPsTweet
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Mashup Score: 7
The astonishing case of Aliria Rosa Piedrahita de Villegas captivated scientists because she was spared the wrath of her Paisa presenilin 1 mutation. She staved off dementia for three decades longer than her kin and had few neurofibrillary tangles, mild hippocampal neurodegeneration, and minimal neuroinflammation despite a high amyloid plaque load (Sep 2022 conference news). Piedrahita de Villegas carried two copies of a rare APOE3 variant called Christchurch. Was this really to thank for her delayed
Source: www.alzforum.orgCategories: General Medicine News, NeurologyTweet-
Check out my thoughts at the end of this: APOE Christchurch Variant Tames Tangles and Gliosis in Mice. Great story @alzforum on papers by the Huang Lab and @holtzman4 Lab. Protective APOE missense variants are very rare and exceedingly important! https://t.co/PrWRDiBREF
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Mashup Score: 0
Diagnostic criteria for Alzheimer’s disease were revised only five years ago, but the field has learned a lot since then. At the Alzheimer’s Association International Conference, held last month in Amsterdam, Clifford Jack of the Mayo Clinic in Rochester, Minnesota, proposed updates to the current “ATN” system. Like the 2018 criteria, the new ones are the product of a joint National Institute on Aging-Alzheimer’s Association working group Jack leads. The draft criteria take into account recent discoveries
Source: www.alzforum.orgCategories: Healthcare Professionals, Latest HeadlinesTweet-
Revised Again: #Alzheimer's Diagnostic Criteria Get Another Makeover https://t.co/cfzvjI5Llc #amyloid #tau #amyloidPET #tauPET #cognition #memory #MCI #plaques #tangles #stages #PM101 https://t.co/ti3mJ7xOJB
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Mashup Score: 6Nature Aging Issue Focuses on Dementia Research | ALZFORUM - 11 month(s) ago
26 May 2023 Feel like catching up on the field over Memorial Day weekend? Here’s some reading for you. Covering animal models to clinical trials, nine articles in the May issue of Nature Aging discuss current challenges and opportunities in dementia research. In their perspective, Pranesh Padmanabhan and Jürgen Götz, University of Queensland, Brisbane, Australia, dispute that…
Source: www.alzforum.orgCategories: Healthcare Professionals, Latest HeadlinesTweet-
RT @alzforum: The May issue of Nature Aging offers a spread on advances and opportunities in dementia research. https://t.co/7KsLf3XcPm
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Mashup Score: 0Long COVID and Dementia: The Link Is Still Elusive | ALZFORUM - 12 month(s) ago
05 May 2023 With the emergence of COVID-19 three years in the past, the lingering neurological effects after initial illness remain nebulous. At the recent International Conference on Alzheimer’s and Parkinson’s Diseases in Gothenburg, Sweden, scientists presented data from ongoing longitudinal trials studying the neurological effects of long COVID. Others tied the APOE4 genotype to…
Source: www.alzforum.orgCategories: Healthcare Professionals, Latest HeadlinesTweet-
#LongCOVID and #Dementia: The Link Is Still Elusive https://t.co/26Wkzd85xI
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Mashup Score: 0
17 Mar 2023 Here’s a tau twist that may take some adapting to. CD4+ and CD8+ T cells, yes, those mercurial executioners of the immune system, may be responsible for the neurodegeneration seen in Alzheimer’s disease and other tauopathies. That’s the scenario outlined by David Holtzman, Washington University, St. Louis, and colleagues in Nature on March 8. The scientists report that,…
Source: www.alzforum.orgCategories: Healthcare Professionals, Latest HeadlinesTweet-
#Neurodegeneration—It’s Not the Tangles, It’s the #TCells https://t.co/571GEFzpMZ #microglia #CD8+ #meninges #brain #parenchyma #immunity #PD1 #dementia #amyloid #tau #Aβ Activated immune cells drive neurodegeneration in an #Alzheimer’s model https://t.co/VUaJjzkPk7 Can #AD… https://t.co/UGZigewVsm https://t.co/3BL4qnK4CR
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Mashup Score: 1Tofersen | ALZFORUM - 1 year(s) ago
Name: Tofersen Synonyms: BIIB067, Ionis-SOD1Rx, ASO1 Therapy Type: DNA/RNA-based Target Type: Other (timeline) Condition(s): Amyotrophic Lateral Sclerosis U.S. FDA Status: Amyotrophic Lateral Sclerosis (Phase 3) Company: Biogen, IONIS Pharmaceuticals …
Source: www.alzforum.orgCategories: Latest Headlines, Rare DiseaseTweet-
RT @BrielmaierL: @alsadvocacy a timeline: https://t.co/VmDDUz3fei
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Mashup Score: 0
25 Jan 2023 Synaptic changes lie at the nexus of many neurodegenerative diseases, underpinning cognitive decline. However, it has been hard to get a handle on exactly how these tiny structures change in disease, because scientists have had no way to examine expression changes in single synapses at scale. In the January 16 Nature Biotechnology, researchers led by David Weitz at…
Source: www.alzforum.orgCategories: Future of Medicine, Latest HeadlinesTweet-
@bcmgenetics @BCMGradSchool @BCMCancerCenter @bcmhouston @HarvardCCB @wyssinstitute @hseas @ChenghangZong @endpts Droplets in the bucket? Introducing en masse single-synapse RNA-Seq #NBTintheNews via @alzforum https://t.co/niIrXEtt8W
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Mashup Score: 1
21 Aug 2022 A resolution revolution is happening to spatial transcriptomics. At this year’s Alzheimer’s Association International Conference, held July 31 to August 4 in San Diego, California, and online, Shane Liddelow of New York University presented stunning images of expression within mouse brain slices. Combining single-cell RNA sequencing and in situ hybridization to map gene…
Source: www.alzforum.orgCategories: Future of Medicine, Latest HeadlinesTweet-
@fredhutch @UWBiostat @UWDeptMedicine @UW @10xGenomics @SeattleCCA @uwlabmedpath @raphg @edward130603 High-res spatial transcriptomics offers new views of mouse brain #NBTintheNews via @alzforum https://t.co/xjPFfDnJgj
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Mashup Score: 0
27 Apr 2022 Like a woolly mammoth in a tar pit, proteasomes may be doomed if they get stuck in gobs of the DNA-binding protein TARDP, better known as TDP-43. That’s according to new research from the labs of Dieter Edbauer at the German Center for Neurodegenerative Diseases, Munich, and Rubén Fernández-Busnadiego at the University of Göttingen, Germany. The scientists…
Source: www.alzforum.orgCategories: Latest Headlines, Rare DiseaseTweet-
Death by Goo: TDP-43 Gels Paralyze Proteasomes in Neurons https://t.co/Rg53EAUpqv
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#Meningeal interleukin-17-producing #Tcells mediate cognitive impairment in a mouse model of salt-sensitive #hypertension. https://t.co/AmIOEmLYf7 #IL17 #arachnoid #cognition #bloodpressure #CSF Molecular anatomy of adult mouse #leptomeninges https://t.co/DiXSP03Wm5… https://t.co/CrFOdQvc4D https://t.co/4Yjh9xpGcs