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Mashup Score: 0
27 Apr 2022 Like a woolly mammoth in a tar pit, proteasomes may be doomed if they get stuck in gobs of the DNA-binding protein TARDP, better known as TDP-43. That’s according to new research from the labs of Dieter Edbauer at the German Center for Neurodegenerative Diseases, Munich, and Rubén Fernández-Busnadiego at the University of Göttingen, Germany. The scientists…
Source: www.alzforum.orgCategories: Latest Headlines, Rare DiseaseTweet
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Mashup Score: 6Stroke Severity, Recurrence Increase Dementia Risk | ALZFORUM - 2 year(s) ago
28 Jan 2022 Stroke raises a person’s likelihood of developing dementia. Does a severe stroke or having multiple strokes further increase risk? Yes, according to researchers led by Silvia Koton and Josef Coresh, Johns Hopkins University, Baltimore, and Rebecca Gottesman of the National Institute of Neurological Disorders and Stroke, Bethesda, Maryland. In the January 24…
Source: www.alzforum.orgCategories: Geriatrics, Latest HeadlinesTweet-
RT @brunovellas: Stroke Severity, Recurrence Increase Dementia Risk | ALZFORUM https://t.co/U0OLzEC9yT
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Mashup Score: 0
01 Dec 2021 APOE4 is the strongest genetic risk factor for sporadic Alzheimer’s disease, but at what age does the risk start to play out? A new study hints that it might be as young as one’s 30s. In the November 10 Science Advances, researchers led by Madhav Thambisetty, National Institute on Aging, Baltimore, reported that 24 proteins upregulated in the brains of young…
Source: www.alzforum.orgCategories: Expert Picks, Latest HeadlinesTweet-
Young ApoE4 Carriers Have Reversed AD Proteomic Signature | ALZFORUM #kahnchronicle https://t.co/pgRrpXXjEv
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Mashup Score: 1
01 Dec 2021 APOE4 is the strongest genetic risk factor for sporadic Alzheimer’s disease, but at what age does the risk start to play out? A new study hints that it might be as young as one’s 30s. In the November 10 Science Advances, researchers led by Madhav Thambisetty, National Institute on Aging, Baltimore, reported that 24 proteins upregulated in the brains of young…
Source: www.alzforum.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @MadhavThambiset: Young ApoE4 Carriers Have Reversed AD Proteomic Signature https://t.co/tO6Bbi9tY9 An extensive write up on our recent…
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Mashup Score: 1
20 Apr 2019 Thirty missense mutations in amyloid precursor protein are known to cause autosomal-dominant Alzheimer’s disease. Now, scientists at Uppsala University, Sweden, have identified a deletion in the APP gene that does the same thing. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, Portugal, María Pagnon de la Vega…
Source: www.alzforum.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @MadhavThambiset: More than 2 years since presenting APP deletion associated with early onset AD https://t.co/QqZGnUICa8 paper now in ST…
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Mashup Score: 1Seeking Real-World Data on Whether Aducanumab Works | ALZFORUM - 3 year(s) ago
13 Aug 2021 The Food and Drug Administration’s conditional approval of aducanumab (Aduhelm) left most researchers and clinicians with a big question: does the drug really work to slow cognitive and clinical decline? Post-market research will now try to answer this question. At the Alzheimer’s Association International Conference, held July 26-30 in Denver, Colorado, James Galvin of…
Source: www.alzforum.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @MadhavThambiset: https://t.co/qZMa0cLj00 on Real-World #Aducanumab data. ICARE-AD has no control arm-so can't directly assess how patie…
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Mashup Score: 6Polyamines–What Role in Neurodegeneration? | ALZFORUM - 3 year(s) ago
14 May 2021 Part 2 of two Polyamines, the nitrogen-packed aliphatic molecules produced by our own cells and found in the foods we eat, have been cast by some as anti-aging dynamos. Studies suggest the compounds, most notably spermidine, counter cognitive slippage in animal models by revving up autophagy and mitochondrial function in the brain. One pilot trial hinted that…
Source: www.alzforum.orgCategories: Expert Picks, Latest HeadlinesTweet-
Polyamines–What Role in Neurodegeneration? - https://t.co/pGNVdFEhOu #Kahnchronicle
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Mashup Score: 0Polyamines–What Role in Neurodegeneration? | ALZFORUM - 3 year(s) ago
14 May 2021 Part 2 of two Polyamines, the nitrogen-packed aliphatic molecules produced by our own cells and found in the foods we eat, have been cast by some as anti-aging dynamos. Studies suggest the compounds, most notably spermidine, counter cognitive slippage in animal models by revving up autophagy and mitochondrial function in the brain. One pilot trial hinted that…
Source: www.alzforum.orgCategories: Cardiologists, Latest HeadlinesTweet-
Polyamines–What Role in Neurodegeneration? | ALZFORUM. #kahnchronicle @spermidineLIFE https://t.co/K4CvhfyW4S
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Mashup Score: 0Better Living Through Polyamines? | ALZFORUM - 3 year(s) ago
14 May 2021 Part 1 of two Could primordial soup, semen, and rotting flesh hold clues to healthy cognitive aging? If the idea sounds a little repulsive, consider this. These three types of complex organic matter are all packed with polyamines—flat strings of amine groups that have been around since life began, are so concentrated in semen spermidine crystals form, and as…
Source: www.alzforum.orgCategories: Cardiologists, Latest HeadlinesTweet-
Better Living Through Polyamines? | ALZFORUM. #kahnchronicle @spermidineLIFE https://t.co/jcHOryV9w3
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Mashup Score: 3Forget Typical Alzheimer's: AI Finds Four Types. | ALZFORUM - 3 year(s) ago
30 Apr 2021 Is idiopathic Alzheimer’s more than one disease? And is there even such a thing as “typical” AD? Given the heterogeneity in clinical presentation and pathology, some scientists have suggested as much for years, but with the exception of certain rare, atypical forms, no consensus has emerged on subtypes of AD. That might be about to change. In the April 29…
Source: www.alzforum.orgCategories: Geriatrics, Latest HeadlinesTweet-
RT @brunovellas: Forget Typical Alzheimer's: AI Finds Four Types. https://t.co/2LhPjBqNXX
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Death by Goo: TDP-43 Gels Paralyze Proteasomes in Neurons https://t.co/Rg53EAUpqv