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Mashup Score: 0
BACKGROUND: Ca2+ signals in smooth muscle cells (SMCs) contribute to vascular resistance and control blood pressure. Increased vascular resistance in hypertension has been attributed to impaired SMC
Source: CirculationCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Effects of Coronary Artery Disease–Associated Variants on Vascular Smooth Muscle Cells - 2 year(s) ago
BACKGROUND: Genome-wide association studies have identified many genetic loci that are robustly associated with coronary artery disease (CAD). However, the underlying biological mechanisms are still
Source: CirculationCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 8
BACKGROUND: Vascular smooth muscle cells (SMCs) undergo complex phenotypic modulation with atherosclerotic plaque formation in hyperlipidemic mice, which is characterized by de-differentiation and he
Categories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 1Yes-Associated Protein Targets the Transforming Growth Factor β Pathway to Mediate High-Fat/High-Sucrose Diet-induced Arterial Stiffness - 2 year(s) ago
Background: Metabolic syndrome is related to cardiovascular diseases, which is attributed in part, to arterial stiffness; however, the mechanisms remain unclear. The present study aimed to investigat
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Arterial Delivery of VEGF-C Stabilizes Atherosclerotic Lesions - 3 year(s) ago
FootnotesFor Sources of Funding and Disclosures, see page 285.Correspondence to: Oliver Soehnlein, MD, PhD, Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Pettenkoferstr. 9, 80336 Munich. Email oliver.[email protected]comReferences1. Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, et al.; CANTOS Trial…
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 3
Rationale: Tamoxifen prevents the recurrence of breast cancer and is also beneficial against bone demineralization and arterial diseases. It acts as an ER (estrogen receptor) α antagonist in ER-posit
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Zahreddine, et al demonstrate that nuclear ERa in #SmoothMuscleCells is necessary to induce endothelial healing by #tamoxifen but not #estrogen. Learn about the duality of tamoxifen as an antagonist for #BreastCancer and an agonist to protect #arteries https://t.co/tuHtUByelp https://t.co/MnSZuwHlcr
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#OriginalResearch: TRPV4 channels in #SmoothMuscleCells are essential regulators of resting blood pressure, and an imbalance in these channels contributes to elevated blood pressure in #hypertension @UVAneurosurg #AHAJournals https://t.co/sjOIK561ml https://t.co/cSCoAZYkBf