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Mashup Score: 6
NUP98 fusion oncoproteins promote leukemogenesis by undergoing phase separation in the nuclei of hematopoietic cells to form hundreds of punctate transcriptional condensates that drive aberrant gene expression and induce myeloid transformation.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 4Temporal and spatial characterisation of protein liquid-liquid phase separation using NMR spectroscopy - Nature Communications - 2 year(s) ago
Protein liquid-liquid phase separation is an important phenomenon in biology. Here, the authors demonstrate an approach to characterize the evolution of protein phases in both time and space using a fluorinated probe molecule in NMR spectroscopy.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Researchers from @UoMChemistry @OfficialUoM report an approach to characterize protein liquid-liquid phase separation by NMR using a fluorinated probe molecule #Condensates #PhaseSeparation https://t.co/ZNqwjkFvvz https://t.co/Mux6nh9gGe
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Mashup Score: 8
The authors show that prion protein and α-synuclein undergo phase separation through domain-specific electrostatic interactions. These complex coacervates possess electrostatic nanoclusters and can convert into multiphasic condensates and amyloids.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet-
Researchers from @SamratLabMohali report that prion protein and α-synuclein phase separate together. These complex coacervates possess electrostatic nanoclusters and can convert into multiphasic condensates and amyloids. #PhaseSeparation, #Condensates https://t.co/wqooFxyyWS https://t.co/tSds9BXxjr
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Mashup Score: 11
NUP98 fusion oncoproteins (FOs) are drivers in pediatric leukemias and many transform hematopoietic cells. Most NUP98 FOs harbor an intrinsically disordered region from NUP98 that is prone to liquid-liquid phase separation (LLPS) in vitro. A predominant class of NUP98 FOs, including NUP98-HOXA9 (NHA9), retains a DNA-binding homeodomain, whereas others harbor other types of DNA- or…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
#PhaseSeparation mediates NUP98 Fusion Oncoprotein Leukemic Transformation. https://t.co/evpHJuizEo @bappa_academic @kriwacki @CMullighan @StJudeStructBio @StJudeResearch #leusm https://t.co/YT89GM1a9z
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Mashup Score: 0Glycogen condensates drive tumorigenesis by trapping Hippo kinases - Nature Reviews Cancer - 3 year(s) ago
Liu et al. show that glycogen accumulates in pre-malignant liver cells by undergoing liquid–liquid phase separation and, by sequestering Hippo kinases MST1 and MST2, promotes YAP-driven tumorigenesis.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
NEW #ResearchHighlight! Liu et al. show that #glycogen undergoes liquid–liquid #PhaseSeparation in pre-malignant liver cells by and, by sequestering Hippo kinases MST1 and MST2, promotes #YAP-driven #tumorigenesis. @CellCellPress 📯 https://t.co/xRSVoQhVDB @natrescancer https://t.co/xU3pKGgMLE
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Mashup Score: 1Voices of the new generation: establishing yourself as a PI in a competitive field - Nature Reviews Molecular Cell Biology - 3 year(s) ago
Jonathon Ditlev shares his thoughts on building a research programme in a competitive field.
Categories: Allergy-Immunology, Latest HeadlinesTweet-
In our November issue check out this World View, where Jonathon Ditlev shares his thoughts on building a research programme in a competitive field of #LLPS #PhaseSeparation #BiomolecularCondensates @Jonathon_Ditlev https://t.co/Y5x05OoJym FREE pdf: https://t.co/dNs0gIRq8J https://t.co/a2laP4nAxT
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Mashup Score: 11RNA polymerase II transcription compartments:... - 3 year(s) ago
Recent studies invoke phase separation as a mechanism underlying the formation of ‘transcriptional condensates’. However, similarities between transcriptional condensates and the previously introduced ‘transcription factories’ model raise the question of what distinguishes the two models. One crucial aspect to consider is the contribution of intrinsically disordered regions in…
Source: www.nature.comCategories: Allergy-Immunology, Latest HeadlinesTweet-
Also read this Comment where @KarstenRippe @AkisPapantonis suggest that IDRs in transcription-relevant factors underlie formation of both ‘transcriptional condensates’ and ‘transcription factories’ #phaseseparation #transcription FREE pdf: https://t.co/nJumoyYcfN #sharedit https://t.co/SmvfmdEVEr
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Mashup Score: 7Voices of the new generation: establishing yourself as a PI in a competitive field - Nature Reviews Molecular Cell Biology - 3 year(s) ago
Jonathon Ditlev shares his thoughts on building a research programme in a competitive field.
Categories: Allergy-Immunology, Latest HeadlinesTweet-
In this World View article Jonathon Ditlev shares his thoughts on building a research programme in a competitive field of #LLPS #PhaseSeparation #BiomolecularCondensates @Jonathon_Ditlev @SickKidsNews https://t.co/Y5x05OoJym https://t.co/n6oIZOW8Pg
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Mashup Score: 4Research illuminates earliest part of phase separation - 3 year(s) ago
St. Jude scientists study how phase separation begins on a microsecond time scale, showing how the earliest events with individual molecules impact assembly speed.
Source: www.stjude.orgCategories: General Medicine News, Latest HeadlinesTweet-
RT @StJudeResearch: Research shows how #phaseseparation begins on the microsecond timescale. https://t.co/xjdd82D2gI @TanjaMittag @NatureCo…
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Mashup Score: 2RNA polymerase II... - Nature Reviews Molecular Cell Biology - 3 year(s) ago
Recent studies invoke phase separation as a mechanism underlying the formation of ‘transcriptional condensates’. However, similarities between transcriptional condensates and the previously introduced ‘transcription factories’ model raise the question of what distinguishes the two models. One crucial aspect to consider is the contribution of intrinsically disordered regions in…
Source: www.nature.comCategories: Allergy-Immunology, Latest HeadlinesTweet-
!Comment! @KarstenRippe @AkisPapantonis suggest that IDRs in transcription-relevant factors underlie formation of both ‘transcriptional condensates’ and ‘transcription factories’ #phaseseparation #transcription FREE pdf: https://t.co/nJumoyYcfN #sharedit https://t.co/YaON5kBczn
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From the April issue: #PhaseSeparation mediates NUP98 Fusion Oncoprotein Leukemic Transformation, by @bappa_academic, @NMichmerhuizen, @HazheenM, @kriwacki, @CMullighan et al. https://t.co/mirs29ADGl @StJudeStructBio @StJudeResearch https://t.co/84EHc1VIkU