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Mashup Score: 14Hallmarks of Cancer: New Dimensions - 2 year(s) ago
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity of cancer phenotypes and genotypes into a provisional set of underlying principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and disrupted differentiation is a discrete…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 14Mesenchymal Lineage Heterogeneity Underlies Nonredundant Functions of Pancreatic Cancer–Associated Fibroblasts - 2 year(s) ago
Cancer-associated fibroblast (CAF) heterogeneity is increasingly appreciated, but the origins and functions of distinct CAF subtypes remain poorly understood. The abundant and transcriptionally diverse CAF population in pancreatic ductal adenocarcinoma (PDAC) is thought to arise from a common cell of origin, pancreatic stellate cells (PSC), with diversification resulting from cytokine and growth…
Source: Cancer DiscoveryCategories: Latest Headlines, Oncologists1Tweet-
Yet more beautiful work from the @MaraShermanLab now out in: @CD_AACR.https://t.co/GhgC6HszOo. With a perspective by @ednacukierman: https://t.co/HGFu9Kuend
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Mashup Score: 10
Summary: Cancer-associated fibroblast (CAF) pro– and anti–pancreatic cancer functional dichotomy has been at the center of numerous studies. In this issue of Cancer Discovery , Helms and colleagues demonstrate that although pancreatic stellate cell–derived CAFs constitute a desmoplastic cell minority, these cells play a protumorigenic role via microenvironmental mechanomodulation. See related…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 31Hallmarks of Cancer: New Dimensions - 2 year(s) ago
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity of cancer phenotypes and genotypes into a provisional set of underlying principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and disrupted differentiation is a discrete…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
New Dimension Hallmark: Senescent cells: denoted as a significant contributor to the #tumormicroenvironment, these cells can affect tumor development and progression #HallmarksofCancer. https://t.co/QOCv75pvpp https://t.co/6ZmsAe18C1
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Mashup Score: 0Improving the Affordability of Anticancer Medicines Demands Evidence-Based Policy Solutions - 2 year(s) ago
The high cost of many new anticancer medicines significantly impedes breakthrough discoveries from reaching patients. A commonly heard refrain is that high prices are necessary to compensate for the high costs of research and development (R&D). Yet, there are promising policy proposals aimed at improving affordability without compromising innovation. In seeking new policy solutions, we argue for…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 4
Mutant KRAS promotes type 2 immunity through upregulation of IL33 in pancreatic ductal adenocarcinoma (PDAC).
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2
Mutant KRAS promotes type 2 immunity through upregulation of IL33 in pancreatic ductal adenocarcinoma (PDAC).
Source: Cancer DiscoveryCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
A natural immune response was generated to somatic mutations in metastatic breast cancer patients.
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 3
Combination trametinib and nintedanib induces cell death and reprograms the immunosuppressive microenvironment.
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
A pan-cancer analysis reveals associations between genomic alterations and metastatic patterns.
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
Next Dimension Hallmark— Polymorphic #microbiomes: The vast array of microbes present within us can affect cancer development, progression, and therapy response. https://t.co/nkwkorTcYT #HallmarksofCancer https://t.co/WK1g9Xiglm