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Mashup Score: 42A melanoma subtype emerges from the shadows - 1 month(s) ago
An understudied melanoma arises without sun exposure, but researchers are beginning to shed light on this challenging form of skin cancer.
Source: www.drugdiscoverynews.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 74Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons - 4 month(s) ago
Nature Biotechnology – Neurons derived from stem cells are rapidly matured with a GENtoniK cocktail.
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 69Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons - 4 month(s) ago
Nature Biotechnology – Neurons derived from stem cells are rapidly matured with a GENtoniK cocktail.
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 47
Small nucleotide variants in non-coding regions of the genome can alter transcriptional regulation, leading to changes in gene expression which can activate oncogenic gene regulatory networks. Melanoma is heavily burdened by non-coding variants, representing over 99% of total genetic variation, including the well-characterized TERT promoter mutation. However, the compendium of regulatory…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 13A century of the Warburg effect - Nature Metabolism - 6 month(s) ago
In 1923, Otto Warburg published his landmark study , in which he described his seminal observations related to metabolic shifts in cancer, often referred to as the Warburg effect. His work laid the foundation for an understanding of how metabolic reconfiguration contributes to cancer onset and progression. Several researchers in the field share their thoughts on what this discovery means to them…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 87
In a recent study, Tagore et al. find that the formation of synapse-like structures that serve to transfer GABA between premalignant melanocytes and keratinocytes promotes melanoma initiation by the BRAFV600E oncogene.
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 21Night Science on Apple Podcasts - 6 month(s) ago
Science · 2023
Source: podcasts.apple.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 3Probiotic-guided CAR-T cells for solid tumor targeting - 7 month(s) ago
Engineered probiotics produce synthetic targets to facilitate immunotherapy of solid tumors by CAR T cells.
Source: www.science.orgCategories: Latest Headlines, Oncologists1Tweet
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Mashup Score: 0Desmosome mutations impact the tumor microenvironment to promote melanoma proliferation - 8 month(s) ago
Desmosomes are transmembrane protein complexes that contribute to cell-cell adhesion in epithelia and other tissues. Here, we report the discovery of frequent genetic alterations in the desmosome in human cancers, with the strongest signal seen in cutaneous melanoma where desmosomes are mutated in over 70% of cases. In primary but not metastatic melanoma biopsies, the burden of coding mutations on desmosome genes associates with a strong reduction in desmosome gene expression. Analysis by spatial transcriptomics suggests that these expression decreases occur in keratinocytes in the microenvironment rather than in primary melanoma tumor cells. In further support of a microenvironmental origin, we find that loss-of-function knockdowns of the desmosome in keratinocytes yield markedly increased proliferation of adjacent melanocytes in keratinocyte/melanocyte co-cultures. Thus, gradual accumulation of desmosome mutations in neighboring cells may prime melanocytes for neoplastic transformati
Source: www.biorxiv.orgCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 45GABA regulates electrical activity and tumor initiation in melanoma - 9 month(s) ago
Abstract. Oncogenes can only initiate tumors in certain cellular contexts, which is referred to as oncogenic competence. In melanoma, whether cells in the microenvironment can endow such competence remains unclear. Using a combination of zebrafish transgenesis coupled with human tissues, we demonstrate that GABAergic signaling between keratinocytes and melanocytes promotes melanoma initiation by BRAFV600E. GABA is synthesized in melanoma cells, which then acts on GABA-A receptors on keratinocytes. Electron microscopy demonstrates specialized cell-cell junctions between keratinocytes and melanoma cells, and multi-electrode array analysis shows that GABA acts to inhibit electrical activity in melanoma/keratinocyte co-cultures. Genetic and pharmacologic perturbation of GABA synthesis abrogates melanoma initiation in vivo. These data suggest that GABAergic signaling across the skin microenvironment regulates the ability of oncogenes to initiate melanoma.
Source: aacrjournals.orgCategories: Latest Headlines, Oncologists1Tweet
Nice piece about acral melanoma, and the importance of studying it in different ethnic and geographic populations. Featuring work from my lab along with @daniela_oaks and @PatriciaPossik: https://t.co/x3yFdr83xj