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Mashup Score: 4The pathogenesis of mesothelioma is driven by a dysregulated translatome - Nature Communications - 3 year(s) ago
Treating malignant pleural mesothelioma (MpM) is challenging due to a lack of druggable genes, but other molecular features could be clinically useful. Here the authors profile mRNA translation dysregulation in MpM cell lines using polysome profiling, and identify mTORC1 and 2 as potential pharmacological targets.
Source: Nature CommunicationsCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 3Antiepileptogenic effects of rapamycin in a model of infantile spasms due to structural lesions - 3 year(s) ago
Objective Infantile spasms may evolve into persistent epilepsies including Lennox-Gastaut syndrome. We compared adult epilepsy outcomes in models of infantile spasms due to structural etiology (mult…
Source: Wiley Online LibraryCategories: Latest Headlines, NeurologyTweet-
Antiepileptogenic effects of rapamycin in a model of infantile spasms due to structural lesions https://t.co/dRssr78KHo FULL-LENGTH ORIGINAL RESEARCH #epilepsy #LennoxGastaut #Westsyndrome #mTor @IlaeWeb @WileyNeuro https://t.co/wqCMyFSBm2
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Mashup Score: 0mTOR Activation Initiates Renal Cell Carcinoma Development by Coordinating ERK and p38MAPK - 3 year(s) ago
Renal cell carcinoma (RCC) mainly originates from renal proximal tubules. Intriguingly, disruption of genes frequently mutated in human RCC samples thus far has only generated RCC originated from other renal tubule parts in mouse models. This hampers our understanding of the pathogenesis of RCC. Here we show that mTOR signaling, often activated in RCC samples, initiates RCC development from renal…
Source: Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Wu et al generate a new #MouseModel of #RenalCellCarcinoma derived from renal proximal tubules driven by #mTOR activation combined with inactivation of the p38MAPK pathway that mimics human ccRCC. https://t.co/8v7OPfF0gh https://t.co/4vIJRzARk9
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Mashup Score: 4
NRG1 rearrangements produce chimeric ligands that subvert the ERBB pathway to drive tumorigenesis. A better understanding of the signaling networks that mediate transformation by NRG1 fusions is needed to inform effective therapeutic strategies. However, this has been hampered by a paucity of patient-derived disease models that faithfully recapitulate this molecularly defined cancer subset.
Source: Journal of Thoracic OncologyCategories: Hem/Oncs, Latest HeadlinesTweet-
#OncoAlert Preclinical work on #NRG1 xenografts in @JTOonline suggest potential treatment strategies targeting #MTOR. But they also reveal heterogeneity of downstream signaling. Much to learn. #LCSM @Odintsov_I @MLadanyi @natasharekhtman @michael_offin https://t.co/mcfjX67l9W
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Mashup Score: 6
Soon after rapamycin, the first mTOR inhibitor, emerged in 1990s as a potential treatment against unwanted cell proliferation, many cancer experts had hoped emerging drugs targeting mTOR would become a breakthrough targeted therapy for children and adults suffering relapses of acute myeloid leukemia (AML) and other cancers where mTOR activity is abnormally high.
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet-
Novel combination therapy may help overcome #mTOR drug resistance in AML @PNASNews https://t.co/AiEH22ktU8
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Mashup Score: 1Dangerous side effect of widely used psychiatric drug may be treatable with existing medicine - 4 year(s) ago
Scripps Research scientists identify a medicine that prevents and treats a severe reaction to the drug haloperidol, also known as Haldol, commonly used for schizophrenia and bi-polar disorder. October 07, 2020 JUPITER, FL—The widely used psychiatric drug haloperidol, also known as Haldol, can cause a life-threatening adverse event called catalepsy, which leaves patients in…
Source: www.scripps.eduCategories: General Medicine News, Latest HeadlinesTweet-
The #psychiatric drug #haloperidol can cause the dangerous side effect catalepsy. New findings from the Subramaniam Lab show that this could be caused by the activity of the #mTOR protein (here in red) in neuronal #dopamine signaling. https://t.co/Y8ZA0HXGME @nresearchnews https://t.co/5njm5HP6t7
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New #CancerResearch by Anne Willis's group and colleagues: Analysis of the malignant pleural #mesothelioma #translatome with polysome profiling leads to potential #therapeutic targeting of the #mTOR pathway @NatResCancer https://t.co/wA1ZXSzGxt https://t.co/s1Nk1nvhgf