-
Mashup Score: 10Researchers use biophysics to design new vaccines against RSV and related respiratory viruses - 4 day(s) ago
Scripps Research scientists improved existing vaccines by analyzing the molecular structure and stability of viral proteins. LA JOLLA, CA — In most people, the lung-infecting pathogens known as respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) trigger mild cold-like symptoms. But in infants and seniors, these viruses can cause severe pneumonia and even death. Vaccines against both viruses, however, have been difficult to design. Now, Scripps Research scientists have analyzed the structure
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 2
Featured scientists represent a wide range of fields including chemistry, microbiology, immunology, neuroscience and more LA JOLLA, CA — Ten scientists at Scripps Research, an increase from last year, have been named to Clarivate’s annual Highly Cited Researchers ™ list for 2024. This group represents individuals who have demonstrated significant and broad influences in their fields of study, according to the global analytics company Clarivate. Highly Cited Researchers rank in the top 1 percent by
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
For the second year, 10 Scripps Research scientists are named to @Clarivate’s #HighlyCited2024 list! 🎉 Honored for pioneering work in chemistry, microbiology, neuroscience, and more, these leaders continue advancing science and global health. More at: https://t.co/rF31udQxKY https://t.co/J7lviEZ6OT
-
-
Mashup Score: 4
Featured scientists represent a wide range of fields including chemistry, microbiology, immunology, neuroscience and more LA JOLLA, CA — Ten scientists at Scripps Research, an increase from last year, have been named to Clarivate’s annual Highly Cited Researchers ™ list for 2024. This group represents individuals who have demonstrated significant and broad influences in their fields of study, according to the global analytics company Clarivate. Highly Cited Researchers rank in the top 1 percent by
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
For the second year, 10 Scripps Research scientists are named to @Clarivate’s #HighlyCited2024 list! 🎉 Honored for pioneering work in chemistry, microbiology, neuroscience, and more, these leaders continue advancing science and global health. More at: https://t.co/rF31udQxKY https://t.co/J7lviEZ6OT
-
-
Mashup Score: 20Scripps Research on Threads - 13 day(s) ago
October 2024 | 44 min 13 sec Artificial intelligence is revolutionizing what we once thought impossible. But how can we distinguish genuine breakthroughs from mere hype? In this episode of Science Changing Life, we welcome Eric Topol, MD — renowned physician, scientist, and author. As executive vice president at Scripps Research and founder of the Scripps Research Translational Institute and The Gary and Mary West Chair of Innovative Medicine, Dr. Topol shares his thoughts on how AI is transforming
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
#AI is redefining medicine, but what’s real vs. hype? Scripps Research EVP @EricTopol explores AI’s true impact on diagnostics and precision medicine. Hear why he urges being ‘open to change’ in our latest Science Changing Life episode. 🎧 Listen now: https://t.co/Tu4VcCWOD8 https://t.co/mJHwkWYEzZ
-
-
Mashup Score: 11
By examining RNA in hundreds of thousands of individual brain cells, Scripps Research scientists further support that alcohol use disorder could accelerate Alzheimer’s disease progression, paving the way for future targeted treatments. Researchers characterized the gene expression of more than 100,000 individual cells from brains of humans with Alzheimer’s disease and compared the patterns to those in individuals with alcohol use disorder (AUD). Compared to healthy individuals, they showed that there was
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
The Sanna lab has revealed a surprising link between #Alzheimers & #AlcoholUseDisorder. Shared gene expression patterns suggest alcohol may accelerate Alzheimer’s progression. Published in @SfNJournals eNeuro, this work could guide future treatments. More: https://t.co/9uwMPHSjuF https://t.co/srmIoVKMu5
-
-
Mashup Score: 17Calibr-Skaggs announces initial dosing of a first-in-class regenerative lung medicine in a phase 1 trial for idiopathic pulmonary fibrosis - 19 day(s) ago
CMR316 is a once-weekly inhaled, lung-targeted drug designed to precisely expand lung stem cells and regenerate damaged lung tissue. LA JOLLA, CA — The Calibr-Skaggs Institute for Innovative Medicines, the nonprofit drug development division of Scripps Research, announced today that the first dose of a pioneering regenerative lung therapy, CMR316, has been given in a phase 1 trial assessing safety and tolerability in healthy volunteers and patients with idiopathic pulmonary fibrosis (IPF). This once-week
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
Scripps Research’s Calibr-Skaggs has dosed CMR316—an inhaled therapy aiming to regenerate lung tissue via alveolar stem cells—in a phase 1 trial for idiopathic pulmonary fibrosis (IPF), a chronic disease lacking regenerative treatments. More at: https://t.co/vkIkaDSROk https://t.co/gkVxuir62r
-
-
Mashup Score: 9Scripps Research advances breakthrough regenerative medicines to reverse aging-related diseases - 24 day(s) ago
As we grow older, we begin losing the ability to regr ow and regenerate our cells—tissues break down, organ function declines and chronic diseases arise. Scripps Research scientists are developing medicines that target and activate the body’s endogenous stem cells, which play a crucial role in the repair and self-renewal of cells across different tissue types. Credit: Scripps Research Scientists at Scripps Research and its drug discovery arm, Calibr-Skaggs, develop first-in-class small molecules to
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
Scripps Research and Calibr-Skaggs are pioneering small molecule therapies to restore tissues compromised by aging. Led by President & CEO Peter Schultz and Assoc. Prof. @MichaelBollong, these compounds target the heart, lungs, joints and more. Read more: https://t.co/r6MjT6eLGz https://t.co/8wz7500FgK
-
-
Mashup Score: 14“Human mini-brains” reveal autism biology and potential treatments - 1 month(s) ago
A cerebral organoid showing rosettes (or whirls) of newly developing and migrating new neurons (shown in purplish-red). By creating personalized brain “organoids” in the lab, Scripps Research scientists showed how microRNAs impact brain development, and demonstrate how one drug can reverse critical cellular signs of autism. LA JOLLA, CA — Using stem cells generated from patients with a rare and severe form of autism spectrum disorder and intellectual disability, Scripps Research scientists have grown
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
Using stem cells from patients with a rare form of autism, the lab of Stuart Lipton has grown personalized ‘mini-brains’ to uncover how microRNAs impact brain development, showing that NitroSynapsin can reverse critical cellular signs of autism. More at: https://t.co/784iyQHGLX https://t.co/DaU1cBhCpi
-
-
Mashup Score: 13For heavy drinkers, chronic pain associated with alcohol withdrawal could be permanent - 1 month(s) ago
Scripps Research scientists identified the chemical messenger 2-Arachidonoylglycerol (2-AG) could represent a useful drug target for treating allodynia in people with alcoho l use disorder. Scripps Research scientists show that alcohol withdrawal causes long-lasting sensitivity to mechanical stimuli in heavy drinkers, and identify a drug target that could help. LA JOLLA, CA — One of the main physical symptoms of alcohol withdrawal is “allodynia” — increased sensitivity to mechanical stimuli that are
Source: www.scripps.eduCategories: General Medicine News, General NewsTweet-
The lab of Scripps Research Prof. Marisa Roberto finds chronic pain from alcohol withdrawal may be permanent in heavy drinkers. Changes in endocannabinoid signaling reveal 2-AG as a target for treating alcohol-induced allodynia. More at: https://t.co/rVJqyZtyZJ https://t.co/OAJqA1DQ39
-
-
Mashup Score: 94
Stuart Lipton, PhD (left) and Xin Jin, PhD (right). Credit: Scripps Research The two distinct awards will support collaborative research projects into pollution’s impact on autism as well as risk genes in psychiatric disorders. LA JOLLA, CA — Two Scripps Research faculty members and their multi-investigator teams were recipients of the latest round of funding from the California Institute for Regenerative Medicine (CIRM), with awards totaling more than $28 million to support large, collaborative research
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
The @CIRMnews has awarded over $28M to Stuart Lipton and @xinjin for studies on pollution’s role in autism & psychiatric risk genes. Using S-nitrosylation pathways & advanced genomic screens, the projects seek new insights into neuropsychiatric disorders. https://t.co/y0lejpxOSx https://t.co/YnybIOFqsi
-
Unstable F proteins have hindered RSV and hMPV vaccines, but after analyzing their structure, the @lab_zhu uncovered instability caused by an “acidic patch” and re-engineered RSV F proteins to enhance stability and efficacy in pre-clinical models. More: https://t.co/IU7Okj40Jy https://t.co/6sYFrqzccK