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Mashup Score: 34
The Scripps Research team fused the enzyme sialidase onto bispecific T-cell engager (BiTE) molecules, helping break down th e cancer cells’ outer barriers and thereby activating T cells against the cancer. Credit: Scripps Research Scripps Research scientists help T cells more effectively kill solid tumors cells in vitro and in mice by tweaking an existing cancer immunotherapy. LA JOLLA, CA — Scientists from Scripps Research have enhanced an existing immunotherapy by removing the sugar coating surrounding
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet
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Mashup Score: 59
LA JOLLA, CA — Inspired by what human liver enzymes can do, Scripps Research chemists have developed a new set of copper-catalyzed organic synthesis reactions for building and modifying pharmaceuticals and other molecules. The new reactions are expected to be widely used in drug discovery and optimization, as well as in other chemistry-based industries. In their study, which initially published in an unedited version on March 28, 2024, in Nature, the chemists showed that their new methods can be used to
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Mashup Score: 17Scripps Research on Threads - 12 day(s) ago
April 2024 | 37 min 34 sec Donna Blackmond never thought her career would lead to solving how life first formed on the prebiotic Earth. But as she points out in this episode of Science Changing Life, does any scientist start out knowing where their research will take them? Blackmond, who is a professor and the John C. Martin Endowed Chair in Chemistry at Scripps Research, shares how her wide-ranging background across chemistry and chemical engineering is helping answer some of today’s biggest questions
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Mashup Score: 37Scripps Research on Threads - 16 day(s) ago
April 2024 | 37 min 34 sec Donna Blackmond never thought her career would lead to solving how life first formed on the prebiotic Earth. But as she points out in this episode of Science Changing Life, does any scientist start out knowing where their research will take them? Blackmond, who is a professor and the John C. Martin Endowed Chair in Chemistry at Scripps Research, shares how her wide-ranging background across chemistry and chemical engineering is helping answer some of today’s biggest questions
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet
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Mashup Score: 65
Blocking long phosphate molecules could eventually help treat chronic infections in which slow-growing bacteria evade typical antibiotics. LA JOLLA, CA — Most disease-causing bacteria are known for their speed: In mere minutes, they can double their population, quickly making a person sick. But just as dangerous as this rapid growth can be a bacterium’s resting state, which helps the pathogen evade antibiotics and contributes to severe chronic infections in the lungs and blood, within wounds, and on the
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Mashup Score: 86Scripps Research chemists devise easier new method for making a common type of building block for drugs - 23 day(s) ago
Jin-Quan Yu, PhD, Bristol Myers Squibb Endowed Chair in Chemistry and Frank and Bertha Hupp Professor of Chemistry. Credit: Scripps Research Scientists transform simple linear amines into saturated heterocycles — ring-shaped structures critical for drug development. LA JOLLA, CA — Ring-shaped chemical structures called saturated heterocycles are found in most FDA-approved drugs but are often difficult to create. Scripps Research chemists have just developed a surprisingly easy method for making many of
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Mashup Score: 30How a new drug prototype regenerates lung tissue - 24 day(s) ago
A new study from Scripps Research and Calibr-Skaggs scientists provides pharmacological proof of concept for an upcoming phase 1 clinical trial. LA JOLLA, CA — Pulmonary diseases are a leading cause of morbidity and mortality worldwide. For many progressive lung diseases like idiopathic pulmonary fibrosis (IPF), a key issue is a low supply of new stem cells to repair and reverse damage. These cells are responsible for regenerating and increasing the growth of healthy tissue — without them, lung function
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Scripps Research & Calibr-Skaggs scientists developed a small molecule to stimulate lung stem cell growth for #IPF treatment. Led by @MichaelBollong & Peter G. Schultz, President & CEO of Scripps Research, related therapy CMR316 heads to phase 1 trials. https://t.co/Ef8DgKYiqf https://t.co/UqBLmZu7wY
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Mashup Score: 15
Structural models of PLD3 and PLD4, enzymes that degrade nucleic acids in the c ytoplasm. The enzymes’ active (or binding) sites are indicated with black arrows. Credit: Scripps Research Scripps Research scientists create atomic-level structural models of enzymes associated with autoimmune and inflammatory diseases, including lupus and Alzheimer’ s. LA JOLLA, CA — When nucleic acids like DNA or RNA build up in a cell’s cytoplasm, it sets off an alarm call for the immune system. Enzymes usually clear
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Mashup Score: 90A simple, inexpensive way to make carbon atoms bind together - 29 day(s) ago
An image of tert-butane, the simplest quaternary carbon. Credit: Scripps Research A Scripps Research team uncovers a cost-effective method for producing quaternary carbon molecules, which are critical for drug development. LA JOLLA, CA — The active ingredient in many drugs is what’s known as a small molecule: bigger than water, much smaller than an antibody and mainly made of carbon. It’s tough, however, to make these molecules if they require a quaternary carbon — a carbon atom bonded to four other
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Mashup Score: 43Developing a vaccine for the “zombie drug” xylazine - 30 day(s) ago
Kim D. Janda, PhD, the Ely R. Callaway, Jr. Professor of Chemistry at Scripps Research. Credit: Scripps Research Scripps Research chemical biologists design an early “proof-of-concept” vaccine that could lead to the first effective treatment of xylazine overdose in people. LA JOLLA, CA — Xylazine is an FDA-approved sedative and pain reliever for use in animals, but it has severe adverse effects when used in humans. It is now illicitly being added to opioids, like fentanyl and heroin, as well as cocaine —
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet
A new study in @natBME introduces a fusion molecule that merges sialidase with BiTE technology. Led by @pengwuTSRI and Zhuo Yang, PhD, this approach enhanced T-cell effectiveness against #melanoma, breast, and prostate #cancers. More below: https://t.co/LL6hsBOr8d https://t.co/v3gI1Uuhqv