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Mashup Score: 25
A Scripps Research team found that a new therapeutic that targets the kappa opioid receptor in the brain may reduce alcohol dependence. LA JOLLA, CA — Scripps Research scientists have found that LY2444296 — a compound that selectively blocks the kappa opioid receptor (KOP) — may reduce drinking in cases of alcohol dependence in animal studies. The findings, which were published March 9, 2024, in Scientific Reports, could eventually inform new treatment options for people who experience alcohol use
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet
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Mashup Score: 14How neural inhibition could reduce alcohol use - 2 month(s) ago
A Scripps Research team shows that suppressing the activity of certain stress neurons may decrease alcohol use — but not anxiety — in comorbid cases of post-traumatic stress disorder and alcohol use disorder. LA JOLLA, CA — Neuroscientists at Scripps Research have found that inhibiting neurons involved in the body’s stress response may reduce alcohol consumption in people who have both post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) — even if they still experience trauma-related
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0
New Scripps Research trial aims to validate the use of wearables in guiding participants to effectively monitor mental, physical and emotional exertion — a strategy called pacing. Long COVID Wearable Study principal investigator Julia Moore Vogel, PhD, explains how the study aims to gather rigorous scientific evidence on the role pacing may play in improving symptom management for long COVID patients. Credit: Scripps Research LA JOLLA, CA — Scientists at the Scripps Research Digital Trials Center have
Source: www.scripps.eduCategories: General Medicine News, General NewsTweet
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Mashup Score: 20
Veena Kollery, PhD; Ashok Deniz, PhD; and Sunil Pulletikurti, PhD. Credit: Scripps Research New phospholipid discovery brings researchers closer to understanding how primordial cells emerged during origin of life. LA JOLLA, CA — Roughly 4 billion years ago, Earth was developing conditions suitable for life. Origin-of-life scientists often wonder if the type of chemistry found on the early Earth was similar to what life requires today. They know that spherical collections of fats, called protocells, were
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
Scripps Research Professor Krishnamurthy and his team have revealed how the first cells could have formed on Earth, suggesting phosphorylation may have occurred earlier than expected, offering new insights into how early evolution could have occurred. 🌎 https://t.co/Z4aabC72ul https://t.co/wJHjAtr2pO
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Mashup Score: 6
Veena Kollery, PhD; Ashok Deniz, PhD; and Sunil Pulletikurti, PhD. Credit: Scripps Research New phospholipid discovery brings researchers closer to understanding how primordial cells emerged during origin of life. LA JOLLA, CA — Roughly 4 billion years ago, Earth was developing conditions suitable for life. Origin-of-life scientists often wonder if the type of chemistry found on the early Earth was similar to what life requires today. They know that spherical collections of fats, called protocells, were
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
Scripps Research Professor Krishnamurthy and his team have revealed how the first cells could have formed on Earth, suggesting phosphorylation may have occurred earlier than expected, offering new insights into how early evolution could have occurred. 🌎 https://t.co/Z4aabC72ul https://t.co/wJHjAtr2pO
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Mashup Score: 72Scripps Research scientists honored with prestigious CZI awards to address diseases tied to aging - 2 month(s) ago
Christopher Parker and Giordano Lippi are unraveling the metabolic and protein mechanisms, respectively, that go awry in aging and disease — including Alzheimer’ s. LA JOLLA, CA — How do our cellular mechanics change as we age, including in diseases like Alzheimer’ s? Two Scripps Research scientists have been granted prestigious awards from the Chan Zuckerberg Initiative (CZI) to help answer that expansive question. Christopher Parker, PhD, associate professor of chemistry, is a co-recipient of an
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet-
Congrats to @_chrisgparker_ and @LippiLab for their @ChanZuckerberg (CZI) awards in aging and #Alzheimers research. Parker's work in RNA metabolic networks and Lippi's research on non-coding RNA in neurodegeneration contribute significantly to the field. https://t.co/ZLqTY4mAzl https://t.co/cW9GdqakBC
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Mashup Score: 54How molecular “handedness” emerged in early biology - 2 month(s) ago
Senior author Donna Blackmond, PhD, and co-first authors Jinhan Yu and Min Deng, PhD, of the recent Nature study. Credit: Scripps Research Scripps Research chemists fill a major gap in origin-of-life theories. LA JOLLA, CA — Molecules often have a structural asymmetry called chirality, which means they can appear in alternative, mirror-image versions, akin to the left and right versions of human hands. One of the great mysteries about the origins of life on Earth is that virtually all of the fundamental
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Mashup Score: 39Snaking toward a universal antivenom - 2 month(s) ago
Scripps Research scientists discovered an antibody that represents a large step toward creating a universal antivenom, which would be effective against the venom of all snakes. Credit: Simon Townsley Scripps Research scientists discovered antibodies that protect against a host of lethal snake venoms. LA JOLLA, CA — Scripps Research scientists have developed an antibody that can block the effects of lethal toxins in the venoms of a wide variety of snakes found throughout Africa, Asia and Australia. The
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet
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Mashup Score: 32Snaking toward a universal antivenom - 3 month(s) ago
Scripps Research scientists discovered an antibody that represents a large step toward creating a universal antivenom, which would be effective against the venom of all snakes. Credit: Simon Townsley Scripps Research scientists discovered antibodies that protect against a host of lethal snake venoms. LA JOLLA, CA — Scripps Research scientists have developed an antibody that can block the effects of lethal toxins in the venoms of a wide variety of snakes found throughout Africa, Asia and Australia. The
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet
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Mashup Score: 19Calibr-Skaggs announces expansion of option and license agreement with AbbVie to develop novel cell therapies for solid tumors and autoimmune diseases - 3 month(s) ago
LA JOLLA, CA — The Calibr-Skaggs Institute for Innovative Medicines, the nonprofit drug development division of Scripps Research, announced today that AbbVie (NYSE: ABBV) has expanded its collaboration to further explore Calibr-Skaggs’ switchable CAR-T (sCAR-T) platform in solid tumor indications and autoimmune diseases. “The activity of our switchable CAR-T cell platform has exceeded even our expectations in these early clinical results,” says Travis Young, PhD, Calibr-Skaggs’ vice president of Biologics
Source: www.scripps.eduCategories: General Medicine News, General HCPsTweet
Scripps Research scientists discovered that LY2444296, a compound blocking the kappa opioid receptor, may reduce drinking in alcohol dependence cases. 🧠 Findings published in @SciReports could inform new treatments for people who experience AUD. More: https://t.co/RUht0KwAJP https://t.co/2P6FgZzI9u