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Mashup Score: 0Activation of β2-adrenergic receptors in microglia alleviates neuropathic hypersensitivity in mice - 1 year(s) ago
Drugs enhancing the availability of noradrenaline are gaining prominence in the therapy of chronic neuropathic pain. However, underlying mechanisms are not well understood, and research has thus far focused on α2-adrenergic receptors and neuronal excitability. Adrenergic receptors are also expressed on glial cells, but their roles toward antinociception are not well deciphered. This study…
Source: bioRxivCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 9TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury - Nature Neuroscience - 1 year(s) ago
Zambusi, Novoselc et al. show that granulin-mediated clearance of cytoplasmic TDP-43+ condensates and lipid droplets in injury-activated microglia is required for their return to the homeostatic state and successful brain regeneration.
Source: NatureCategories: Latest Headlines, NeurologyTweet-
After a traumatic brain injury (#TBI) model in zebrafish, clearance of both lipid droplets and TDP-43+ condensates was necessary and sufficient to promote the return of #microglia back to the basal state and achieve scarless regeneration https://t.co/aKtABpLCWo
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Mashup Score: 1Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid - Nature - 2 year(s) ago
Perivascular and leptomeningeal macrophages, collectively termed here parenchymal border macrophages, are shown to regulate flow dynamics of cerebrospinal fluid, implicating this cell population as new therapeutic targets in neurological diseases such as Alzheimer’s.
Source: NatureCategories: Healthcare Professionals, Latest HeadlinesTweet-
Parenchymal border #macrophages regulate the #flowdynamics of the #cerebrospinalfluid https://t.co/01cUEdHCGh "We demonstrate that normal #aging is associated with #PBM dysfunction" #CSF #microglia #glymphatics #EDS #ECM See also pinned tweet: Diseases of the #Leptomeninges #DLM. https://t.co/3oKpvsUhI3
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Mashup Score: 12A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states - Nature Neuroscience - 2 year(s) ago
Dräger et al. establish a rapid, scalable platform for iPSC-derived microglia. CRISPRi/a screens uncover roles of disease-associated genes in phagocytosis, and regulators of disease-relevant microglial states that can be targeted pharmacologically.
Source: NatureCategories: Latest Headlines, NeurologyTweet-
#CRISPR i/a screening platform in human #iPSC-derived #microglia (including an 8-day protocol for generating them) reveals genes controlling microglia survival, activation, and phagocytosis New from @DraegerNina @MartinUCSF @KampmannLab @LiGanLab et al. https://t.co/GK5F9xQUeO
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Mashup Score: 7Please wait whilst we redirect you - 2 year(s) ago
About ScienceDirectRemote accessShopping cartAdvertiseContact and supportTerms and conditionsPrivacy policyWe use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies.Copyright © 2022 Elsevier B.V. or its licensors or contributors. ScienceDirect ® is a registered trademark of Elsevier B.V.ScienceDirect ® is a registered…
Source: www.sciencedirect.comCategories: Allergy-Immunology, Latest HeadlinesTweet-
.@Pengpengstory, Shen, Gu, Bi &co find that #microglia-derived PDGFB promotes neuronal potassium currents to suppress basal sympathetic tonicity & limit hypertension | Disruption of the PDGFB-Kv4.3 pathway predisposes mice to develop #hypertension https://t.co/nefbkqXpMV https://t.co/gR4whFJn68
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Mashup Score: 12Study shows how microglia are prompted to change their state to adapt to different areas of the brain - 2 year(s) ago
From everyday actions like walking and talking to feats of athletic or academic excellence, the brain is constantly acquiring and seamlessly processing information to produce these incredible behaviors. The process requires a whole orchestra of cells listening to each other and tuning their functions to harmonize together. One of the remaining, most fundamental questions in neuroscience asks how…
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet-
Study shows how #microglia are prompted to change their state to adapt to different areas of the #brain @HarvardResearch @nature https://t.co/fPM9dY8Cmt
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Mashup Score: 15How microglia contribute to Alzheimer's disease - 2 year(s) ago
One of the hallmarks of Alzheimer’s disease is a reduction in the firing of some neurons in the brain, which contributes to the cognitive decline that patients experience. A new study from MIT shows how a type of cells called microglia contribute to this slowdown of neuron activity.
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet-
How #microglia contribute to #Alzheimer'sdisease @MIT @CellStemCell https://t.co/xISWdTDhsJ
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Mashup Score: 6Home – Cell Symposia: The Neuro-Immune Axis - 2 year(s) ago
Cell Symposium: Cell Symposia: The Neuro-Immune Axis
Source: www.cell-symposia.comCategories: Allergy-Immunology, Latest HeadlinesTweet-
Hear more about Novel #microglia -astrocytic crosstalk governing activity-dependent synaptic remodeling with Dorothy Schafer @UMassChan @CellSymposia #CSNeuroImmune22. Register before July 1 and save. https://t.co/TvbsqkR96U https://t.co/pN1aDxdHDk
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Mashup Score: 3Home – Cell Symposia: The Neuro-Immune Axis - 2 year(s) ago
Cell Symposium: Cell Symposia: The Neuro-Immune Axis
Source: www.cell-symposia.comCategories: General Medicine News, Latest HeadlinesTweet-
Hear more about Novel #microglia -astrocytic crosstalk governing activity-dependent synaptic remodeling with Dorothy Schafer @UMassChan @CellSymposia #CSNeuroImmune22. Register before July 1 and save. https://t.co/90l74NLxEG https://t.co/wOz3AGiLsX
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Mashup Score: 0The embryonic zebrafish brain is seeded by a lymphatic-dependent population of mrc1+ microglia precursors - Nature Neuroscience - 2 year(s) ago
Green and O’Dea et al. identify that the embryonic zebrafish brain is colonized by a population of early-colonizing microglia that are dependent on lymphatic vessels, placing lymphatic cells at the epicenter of microglia development.
Source: NatureCategories: Latest Headlines, NeurologyTweet-
The embryonic zebrafish brain is seeded by a lymphatic-dependent population of mrc1+ #microglia precursors New from @michaelrodea @camdenhoover3 @cssmity and colleagues https://t.co/Vj7IjCdVrQ
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Activation of β2-adrenergic receptors in #microglia alleviates neuropathic hypersensitivity in mice https://t.co/nIPmPnvLTw #neuropathicpain #formoterol #LABA