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    Embryonic stem cells (ESCs) represent a unique cell population in the blastocyst stage embryo. They have been intensively studied as a promising cell source for regenerative medicine. Recent studies have revealed that both human and mouse ESCs are deficient in expressing IFNs and have attenuated inflammatory responses. Apparently, the ability to express IFNs and respond to certain inflammatory…

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    • #BriefReview by Yan-Lin Guo and Faqing Huang @SouthernMiss discussing Dicer and #PKR as Novel Regulators of #EmbryonicStemCell Fate and Antiviral #InnateImmunity | #ReadTheJI #immunology https://t.co/mYloT1LHnL https://t.co/NctX0myvNF

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    The innate immune system uses pattern recognition receptors to survey the intracellular and extracellular environment for signs of infection. Viral infection is detected through the presence of viral nucleic acids in infected cells. Pattern recognition receptor activation by viral nucleic acids induces the expression and secretion of type I IFNs (IFN-Is), important mediators of antiviral…

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    • #ICYMI from @VanderveenLab @LUMC_Leiden | #BriefReview:Self #RNAsensing by #RIGI-like receptors in #viralinfection and sterile #inflammation #ReadTheJI #immunology #innateimmunity #IFN https://t.co/Lszi77EoCe https://t.co/pdzz9bt8wU