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Mashup Score: 8
Understanding the ways our immune response changes as we age holds the key to designing better vaccines and boosting protection for people most at risk. Research published by Dr. Michelle Linterman and her group today in Nature Immunology has explained that the organization of the germinal center, which is vital to the generation of longer-lived protection following vaccination, is altered in…
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 3
Background: Non-nutritive sweeteners (NNS) are part of personalized nutrition strategies supporting healthy glycemic control. In contrast, the consumption of non-nutritive sweeteners has been related to person-specific and microbiome-dependent glycemic impairments. Reports on the effects of NNS on our highly individual cellular immune system are sparse. The recent identification of taste receptor…
Source: MDPICategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 8
Background: Studies have shown that acute exercise can mobilize several leukocyte subpopulations in healthy individuals. Our aim was to investigate whether a 10-min acute exercise has an effect on immune cell proportions in lymphoma patients.Methods: This study included seven lymphoma patients referred to curative oncologic therapy. Three had Hodgkin and four non-Hodgkin lymphoma, one was female,…
Source: FrontiersCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 2Geospatial characterization of immune cell distributions and dynamics across the microenvironment in clear cell renal cell carcinoma - 1 year(s) ago
Introduction In clear cell renal cell carcinoma (ccRCC), tumor-associated macrophage (TAM) induction of CD8+T cells into a terminally exhausted state has been implicated as a major mechanism of immunotherapy resistance, but a deeper biological understanding is necessary. Methods Primary ccRCC tumor samples were obtained from 97 patients between 2004 and 2018. Multiplex immunofluorescence using…
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Mashup Score: 11How two different types of immune cells help two billion people keep tuberculosis in check - 1 year(s) ago
More than 10 million people are sickened by tuberculosis (TB) globally each year, resulting in 1.5 million deaths. Yet, as many as two billion people are infected with Mycobaterium tuberculosis, the bacterium that causes tuberculosis, and are otherwise healthy and asymptomatic. Scientists who study TB look at those individuals who can tolerate and contain the infection in hopes of developing…
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Mashup Score: 13MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation - Nature Immunology - 1 year(s) ago
Marichal and colleagues use a model of niche depletion and refilling to show that engrafted Ly6C+ classical monocytes proliferate locally in a Csf1 receptor-dependent manner before differentiating into lung interstitial macrophages.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 4Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency - 1 year(s) ago
TBK1 and IKKϵ are related, crucial kinases in antiviral immune signaling pathways downstream of cytosolic nucleic acid receptors such as cGAS and RIG-I-like receptors. Upon activation, they phosphorylate the transcription factors IRF3 and IRF7 and thereby initiate the expression of type I interferons and antiviral effectors. While point mutation-induced loss of TBK1 kinase activity results in…
Source: FrontiersCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 12How immune cells detect and respond to mutations in cancer cells - 1 year(s) ago
For the first time, a research team has identified and analyzed the steps by which immune cells “see” and respond to cancer cells, providing insights into reasons some treatments may be effective for certain patients but not others.
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 5
Melbourne researchers have improved our understanding of how the immune system is regulated to prevent disease, identifying a previously unknown role of ‘natural killer’ (NK) immune cells.
Source: medicalxpress.comCategories: Allergy-Immunology, Latest HeadlinesTweet
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Mashup Score: 5
Melbourne researchers have improved our understanding of how the immune system is regulated to prevent disease, identifying a previously unknown role of ‘natural killer’ (NK) immune cells.
Source: medicalxpress.comCategories: General Medicine News, Latest HeadlinesTweet
'Lost' #immunecells partly to blame for reduced vaccine response in #olderpeople @BabrahamInst @natimmunol https://t.co/q6uNWfCK3M