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Mashup Score: 0Clinical Trials of Cellular Therapies in Solid Tumors - 9 month(s) ago
In the past years cancer treatments have drastically changed, mainly due to the development of immune checkpoint inhibitors capable of immune modulation in vivo, thus providing major clinical benefit in a number of malignancies. Simultaneously, considerable technical refinements have opened new prospects for the development of immune cell-based medicinal products and unprecedented success with…
Source: MDPICategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
Background: Tumour apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (MRI) is a putative pharmacodynamic/response biomarker but the relationship between drug-induced effects on the ADC and on the underlying pathology has not been adequately defined. Hypothesis: Changes in ADC during early chemotherapy reflect underlying histological markers of tumour response…
Source: MDPICategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
📚 We are proud to share our latest #publication on #MRI Apparent Diffusion Coefficient (ADC) as a potential #biomarker for tumour response in patients with hepatic #metastases from #ColorectalCancer. 👉 https://t.co/YvjMS1uNDo #MedicalResearch #ClinicalTrials #Cancer https://t.co/KTJqYk1Zbf
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Mashup Score: 0Exploring Artificial Intelligence in Anesthesia: A Primer on Ethics, and Clinical Applications - 9 month(s) ago
The field of anesthesia has always been at the forefront of innovation and technology, and the integration of Artificial Intelligence (AI) represents the next frontier in anesthesia care. The use of AI and its subtypes, such as machine learning, has the potential to improve efficiency, reduce costs, and ameliorate patient outcomes. AI can assist with decision making, but its primary advantage…
Source: MDPICategories: Healthcare Professionals, Latest HeadlinesTweet-
Exploring Artificial Intelligence in Anesthesia: A Primer on Ethics, and Clinical Applications #some4surgery #some4AI #AI https://t.co/qFc4qV9uZz
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Mashup Score: 0Management of Acute Promyelocytic Leukemia at Extremes of Age - 9 month(s) ago
Tailored treatment with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has revolutionized the outcome of acute promyelocytic leukemia (APL) from a uniformly fatal disease to one of the most curable malignant diseases in humans. Due to its high efficacy, ATO/ATRA is the standard first-line therapy in younger adult, non-high-risk APL patients. However, early death is still a major issue…
Source: MDPICategories: Hem/Oncs, Latest HeadlinesTweet-
Management of Acute Promyelocytic Leukemia at Extremes of Age https://t.co/pWDVyvb64e #mdpicancers #leusm via @Cancers_MDPI
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Mashup Score: 0Bone Marrow Assessment in Liver Cirrhosis Patients with Otherwise Unexplained Peripheral Blood Cytopenia - 10 month(s) ago
We performed a retrospective single-center analysis to investigate the diagnostic yield of bone marrow puncture in patients with liver cirrhosis and cytopenia. Liver cirrhosis patients receiving bone marrow aspiration or biopsy for the diagnostic work-up of otherwise unexplained peripheral blood cytopenia at our institution between 2004 and 2020 were enrolled in this study. We evaluated findings…
Source: MDPICategories: Hem/Oncs, Latest HeadlinesTweet-
Confirmation that bone marrow analysis is not usually required in patients with cytopenias and advanced liver disease. Only 1/118 patients was found to have myelodysplasia to explain the cytopenia. https://t.co/yiW0pvM3RR https://t.co/TWT4gjk3sa
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Mashup Score: 1
Only one in three adults in the United States meets the weekly recommendation for physical activity (PA). The presence of children in the home may restrict adult PA. The purpose of this study was to examine the association between adult moderate and vigorous sport, fitness, and recreational physical activities and the number and age (0–5 and 6–17) of children in their household. Secondary data…
Source: MDPICategories: Healthcare Professionals, Latest HeadlinesTweet-
The Association between Adult Sport, Fitness, and Recreational Physical Activity and Number and Age of Children Present in the Household: A Secondary Analysis Using NHANES https://t.co/k3FIUUooZa
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Mashup Score: 3Building on Foundations: Venetoclax-Based Combinations in the Treatment of Acute Myeloid Leukemia - 10 month(s) ago
Frontline acute myeloid leukemia (AML) treatment is determined by a combination of patient and genetic factors. This includes patient fitness (i.e., comorbidities that increase the risk of treatment-related mortality) and genetic characteristics, including cytogenetic events and gene mutations. In older unfit patients, the standard of care treatment is typically venetoclax (VEN) combined with…
Source: MDPICategories: Hem/Oncs, Latest HeadlinesTweet-
Building on Foundations: Venetoclax-Based Combinations in the Treatment of Acute Myeloid Leukemia https://t.co/2St6dUzbU9 #mdpicancers via @Cancers_MDPI #AML #leusm https://t.co/zGinkdeWQR
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Mashup Score: 3Development of a Transparent Transgenic Zebrafish Cellular Phenotype Tg(6xNF-kB:EGFP); Casper(roy−/−, nacre−/−) to Study NF-kB Activity - 10 month(s) ago
NF-κB signaling has broad effects on cell survival, tissue growth, and proliferation activities. It controls many genes that are involved in inflammation and thus is a key player in many inflammatory diseases. The elevation of NF-κB activators is associated with elevated mortality, especially in cancer and cardiovascular diseases. The zebrafish has emerged as an important model for whole-organism…
Source: MDPICategories: Hem/Oncs, Latest HeadlinesTweet-
Just published a very valuable zebrafish model to study NF-kB activity, led by our expert Dr. Surendra Rajpurohit @ra53008 together with Dr. Bal Lokeshwar. @GACancerCenter https://t.co/BGcw9UZcbl
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Mashup Score: 1Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review - 10 month(s) ago
The Western diet is a modern dietary pattern characterized by high intakes of pre-packaged foods, refined grains, red meat, processed meat, high-sugar drinks, candy, sweets, fried foods, conventionally raised animal products, high-fat dairy products, and high-fructose products. The present review aims to describe the effect of the Western pattern diet on the metabolism, inflammation, and…
Source: MDPICategories: Healthcare Professionals, Latest HeadlinesTweet-
Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review https://t.co/TgaIC4EiqQ
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Mashup Score: 0
Tumor hypoxia (oxygen deficiency) is a major contributor to radiotherapy resistance. Ultrasound-sensitive microbubbles containing oxygen have been explored as a mechanism for overcoming tumor hypoxia locally prior to radiotherapy. Previously, our group demonstrated the ability to encapsulate and deliver a pharmacological inhibitor of tumor mitochondrial respiration (lonidamine (LND)), which…
Source: MDPICategories: Hem/Oncs, Latest HeadlinesTweet-
Improved Tumor Control Following Radiosensitization with Ultrasound-Sensitive Oxygen Microbubbles and Tumor Mitochondrial Respiration Inhibitors in a Preclinical Model of Head and Neck Cancer https://t.co/j2Nm3iTVqn
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Our #TranslationalMedicine link of the week chosen by @SWOG's @recnac1 & Jimmy Rae, PhD: Clinical Trials of Cellular Therapies in Solid Tumors https://t.co/IXcUY2igIf https://t.co/RRX4KKoUM2