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Mashup Score: 0
The impaired endometrial receptivity is a major factor contributing to infertility in patients with endometriosis (EM), but the underlying mechanism remains unclear. Our study aimed to investigate the role of Kruppel-like factor 15 (KLF15) in endometrial receptivity and its regulation in EM. We observed a significant decrease in KLF15 expression in the mid-secretory epithelial endometrial cells of EM patients compared to normal females without EM. To confirm the role of KLF15 in endometrial receptivity, we found a significantly reduced KLF15 expression and a significant decrease in embryo implantation number in the rat model via uterine horn infection with siRNA. This highlights the importance of KLF15 as a regulator receptivity. Furthermore, through ChIP-qPCR, we discovered that the progesterone receptor (PR) directly binds to KLF15 promoter regions, indicating that progesterone resistance may mediate the decrease in KLF15 expression in EM patients. Additionally, we found that the mid
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 1Research Opportunities - 21 day(s) ago
The latest opportunities for advancing endocrinology research
Source: www.endocrine.orgCategories: General Medicine News, EndocrinologyTweet-
#Endometriosis Cures and Therapies: @NICHD_NIH issues a ROA to support and engage with NICHD to develop, advance, and/or validate new devices, and biomarkers for non-invasive diagnosis of endometriosis: https://t.co/ve5NF5sYdq
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Mashup Score: 3Harnessing the inflammatory processes in endometriosis - Nature Reviews Endocrinology - 3 month(s) ago
The pathophysiology of endometriosis is underpinned by a complex interplay of inflammatory processes that are responsible for the local and systemic effects of the condition. Recent studies delve further into this inflammatory interplay; using animal models, they identify potential therapeutic tools and remind us to look beyond the endometriotic lesions.
Source: www.nature.comCategories: General Medicine News, EndocrinologyTweet-
From our February issue: Jane Girling highlights key advances from the past year in #endometriosis research (£) https://t.co/P8n08FpzsK @DrJaneGirling @otago https://t.co/80GdQl8Xou
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Mashup Score: 13
Background There is a lack of evidence that pregnancy reduces endometriotic lesions or symptoms, however studies indicate that people with endometriosis are commonly advised to get pregnant to manage or treat endometriosis. This study sought to examine the impact of this advice on patients with endometriosis when the advice was provided by healthcare professionals. Methods The Endometriosis Patient Experience Survey was a self-reported, community-based, cross-sectional online survey of people who had been medically diagnosed with endometriosis. Descriptive statistics were used to analyse the quantitative survey data and thematic analysis was undertaken for the qualitative survey data. Results 1892 participants had received the advice to get pregnant or have a baby to manage or treat their endometriosis, with 89.4% of participants receiving this advice from healthcare professionals. In exploring the qualitative data, seven themes were contextualised relating to the impact of this advice
Categories: General Medicine News, General HCPsTweet-
Patients told to get pregnant to treat #endometriosis despite lack of evidence, research shows @uniofadelaide https://t.co/vDNJ4hKZdS https://t.co/NMLwHA6KH1
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Mashup Score: 4Harnessing the inflammatory processes in endometriosis - Nature Reviews Endocrinology - 5 month(s) ago
The pathophysiology of endometriosis is underpinned by a complex interplay of inflammatory processes that are responsible for the local and systemic effects of the condition. Recent studies delve further into this inflammatory interplay; using animal models, they identify potential therapeutic tools and remind us to look beyond the endometriotic lesions.
Source: www.nature.comCategories: General Medicine News, EndocrinologyTweet-
Online now: Jane Girling highlights key advances from the past year in #endometriosis research (£) https://t.co/P8n08FpzsK @DrJaneGirling @otago https://t.co/rjI3MGHxDu
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Mashup Score: 3Polygenic risk score phenome-wide association study reveals an association between endometriosis and testosterone - BMC Medicine - 5 month(s) ago
Background Endometriosis affects 1 in 9 women, yet it is poorly understood with long diagnostic delays, invasive diagnoses, and poor treatment outcomes. Characterised by the presence of endometrial-like tissue outside of the uterus, its main symptoms are pain and infertility. Endometriosis often co-occurs with other conditions, which may provide insights into the origins of endometriosis. Methods Here a polygenic risk score phenome-wide association study of endometriosis was conducted in the UK Biobank to investigate the pleiotropic effects of a genetic liability to endometriosis. The relationship between the polygenic risk score for endometriosis and health conditions, blood and urine biomarkers and reproductive factors were investigated separately in females, males and females without an endometriosis diagnosis. The relationship between endometriosis and the blood and urine biomarkers was further investigated using genetic correlation and Mendelian randomisation approaches to identif
Source: bmcmedicine.biomedcentral.comCategories: General Medicine News, General HCPsTweet-
New Research paper from @IsabelleMcGr et al.: Polygenic risk score phenome-wide association study reveals an association between #endometriosis and testosterone: https://t.co/ZBeBkn4eJH https://t.co/HRuoux2bww
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Mashup Score: 7Endometriosis: What you need to know | NIH MedlinePlus Magazine - 6 month(s) ago
Endometriosis affects roughly 10% of women of reproductive age. It has many uncomfortable symptoms including extreme pain in the lower abdomen and back, and pain during bowel movements or menstruation. It can only be diagnosed via surgery, so it’s important to tell your health care provider if you have endometriosis-like symptoms. Learn more about endometriosis and how it’s treated at NIH MedlinePlus Magazine.
Source: magazine.medlineplus.govCategories: General Medicine News, General NewsTweet-
Endometriosis is a painful disease in which tissue, like the endometrial lining inside the uterus, grows in areas outside the uterus. These growths can develop on the ovaries, fallopian tubes, behind the uterus and on the bowels or bladder. https://t.co/h8SHrfLwBy #Endometriosis https://t.co/5zI5zQ6d1K
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Mashup Score: 1Folate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case–Control Study from the Ovarian Cancer Association Consortium - 8 month(s) ago
AbstractBackground:. Although folate intake has not been associated with an increased risk of ovarian cancer overall, studies of other cancer types have suggested that high folate intake may promote carcinogenesis in precancerous lesions. Women with endometriosis (a potential precancerous lesion) have an increased risk of developing ovarian cancer; however, whether high folate intake increases risk in this group is unknown.Methods:. We conducted a pooled analysis of six case–control studies from the Ovarian Cancer Association Consortium to investigate the association between folate intake and risk of ovarian cancer among women with and without self-reported endometriosis. We included 570 cases/558 controls with and 5,171/7,559 without endometriosis. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals for the association between folate intake (dietary, supplemental, and total) and ovarian cancer risk. Finally, we used Mendelian randomization (MR) to eva
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Higher dietary #folate intake is associated with an increased risk of #OvarianCancer for women with #endometriosis but not for women without it, Gersekowski et al find. https://t.co/WMHu1FoEHl https://t.co/CYKZKJ6z3l
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Mashup Score: 0Endometriosis: Why receiving a diagnosis can take up to 11 years - 10 month(s) ago
A range of factors, including a stigma around periods and the normalization of menstrual pain, may contribute to the delay of an endometriosis diagnosis.
Source: www.medicalnewstoday.comCategories: General Medicine News, Latest HeadlinesTweet-
Recent research found that several factors can delay an endometriosis diagnosis by as much as 11 years due to personal and societal barriers and the actions and training of healthcare professionals. #endometriosis https://t.co/ADN6lbQ3KB
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Mashup Score: 2How Many Women Have Endometriosis? Early Symptoms, Risk, and More - 10 month(s) ago
Endometriosis is fairly common — it affects about 10% of people assigned female at birth. Many people with endometriosis are women.
Source: HealthlineCategories: General Medicine News, Latest HeadlinesTweet-
Roughly 190 million people worldwide have endometriosis. We review who’s most at risk of developing endometriosis and the symptoms. #endometriosis https://t.co/QV0GNU7qFT
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Read this recently published, open-access research by Yaxiong Huang et al., providing valuable insights into potential therapeutic approaches for treating non-receptive endometrium in patients with #endometriosis. 👉 https://t.co/4GIn6jsmon https://t.co/m2Ln1BtNT8