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    Whereas reported penicillin allergy is highly prevalent, true allergy is rare. Nonetheless, a reported penicillin allergy is associated with higher rates of alternative broad-spectrum antibiotic use, multidrug-resistant infections, surgical site infections, and higher health care costs and mortality.1,2 Although historically cephalosporins have been avoided in reported penicillin allergy, recent literature supports the safety of its administration in this patient population. In alignment with this understanding, Khan et al1 suggested that patients with nonanaphylactic unverified penicillin allergies can receive cephalosporins without testing, and patients with a history of anaphylaxis to penicillin can be given cephalosporins with structurally dissimilar R1 side chains without testing.

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    Avoidance of cephalosporins and penicillin with beta-lactamase inhibitors during anti-TNF therapy reduced the risk for anti-drug antibodies among patients with inflammatory bowel disease, according to research published in Gut. “Primary non-response to anti-TNF therapy is seen in 40% of patients with even higher rates of failure to achieve complete remission. Additionally, the rate of

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    • Avoidance of #cephalosporins and #penicillin with beta-lactamase inhibitors during #antiTNF therapy reduced the risk for anti-drug antibodies among patients with #IBD, according to research published in @Gut_BMJ #GITwitter #MedTwitter https://t.co/tE2ur4IeIS