• Mashup Score: 0

    x or block pathogenic communication with surrounding cells. However, the type and extent of extracellular changes triggering liver fibrosis depend on the underlying etiology. Our aim was to unveil matrisome genes not dependent on etiology, which are clinically relevant to liver fibrosis. Approach & Results: We used transcriptomic profiles from liver fibrosis cases of different etiologies to identify and validate liver fibrosis-specific matrisome genes (LFMGs) and their clinical and biological relevance. Dysregulation patterns and cellular landscapes of LFMGs were further explored in mouse models of liver fibrosis progression and regression by bulk and single-cell RNA sequencing. We identified 35 LFMGs, independent of etiology, representing an LFMG signature defining liver fibrosis. Expression of the LFMG signature depended on histological severity and was reduced in regressive livers. Patients with liver fibrosis, even with identical pathological scores, could be subclassified into LFM

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    • Chen W et al. La subclasificación basada en genes matrosomas de pacientes con fibrosis hepática identifica heterogeneidades clínicas y moleculares #LiverTwitter https://t.co/APGyDgOgm1 https://t.co/cmrUCzoOWj

    • Chen W et al. Matrisome gene-based subclassification of patients with liver fibrosis identifies clinical and molecular heterogeneities #LiverTwitter https://t.co/APGyDgOgm1 https://t.co/1qCPvcUkJ8

  • Mashup Score: 1

    A 65-year-old man who had a local recurrence in the oral cavity during follow-up after chemoradiotherapy for oropharyngeal carcinoma underwent percutaneous endoscopic gastrostomy (PEG) because of difficulty in oral intake. He had no underlying disease and no relevant family history and was on no medications including antithrombotic drugs. One month after PEG, the patient developed hematemesis at night. He was in shock, and after his condition was stabilized, emergency esophagogastroduodenoscopy (EGD) was performed.

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    • RT @AGA_GHAdvances: Pseudoaneurysm After Percutaneous #Endoscopic Gastrostomy With Repeated Hematemesis ➡️ https://t.co/JX0M6iseKl https://…

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    In a Healio video exclusive, Jan Wehkamp, MD, PhD, reports that treatment with Tremfya maintained clinical remission and endoscopic response through 3 years among patients with moderate to severe Crohn’s disease. “There is still tremendous unmet need for patients with inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis,” Wehkamp, vice president and

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    • In a @GoHealio #GI 🎥 exclusive from #UEGWeek23: Jan Wehkamp, MD, PhD 👨🏻‍⚕️, of @JanssenUS, reports that treatment with #Tremfya maintained clinical remission and endoscopic response through 3 years among patients with #Crohnsdisease. Learn more 👇🏼 https://t.co/E2umREDIhy

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    Submit yourself, or a peer, for an open AGA leadership role through the fall.

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    • Interested in building education programs focused on the most pressing issues in #GI? Nominate yourself or a peer for the #AGA Institute Council, AGA’s committees or to serve as one of AGA’s course directors. Nominations are being accepted through Nov. 1. https://t.co/ERrl15em8N https://t.co/lWMs8vNPT6

  • Mashup Score: 2

    A 78-year-old woman visited a nearby clinic because of discomfort and pain with swallowing. CT showed a 30.0-mm diameter, high-density structure in the upper esophagus, and she was referred to our hospital. Emergency EGD with a soft cap revealed a fish bone horizontally penetrating the esophagus (A). The fish bone was successfully extracted by use of a the grasper, with an esophageal surgeon present. A full-thickness ulcer was observed at the site of fish bone removal, which made it seem difficult to treat with clip suturing (B).

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    • At the Focal Point, Kubo et al show "A novel self-assembling peptide gel for the treatment of ulcer associated with a fish bone penetrating the esophagus." https://t.co/5Mh0fYk46l https://t.co/kuLEa0BqF1