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    Author summary Fungal skin infections known as ringworm or dermatophytosis affect billions of humans and animals worldwide. Normally the disease is self-limiting in affected individuals. The Persian cat breed is a popular breed known for its long hair coat and short nose as well as its propensity to develop severe, chronic dermatophytosis. By examining the genomes of Persian cats, we discovered…

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    • New research on Persian #cats: Myers et al find #genetic variants in the breed related to the incidence of #ringworm These mutations change the antimicrobial protein calprotectin, which may defend against other #pathogens 🔎: https://t.co/pYDL6BLp9Q 📷: Larry Johnson https://t.co/cJBIwIweQ1

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    Caspases are innate immune enzymes that regulate activation of inflammasomes and cell death occurring via pyroptosis. Devant et al . investigated the biological activity of naturally occurring hybrid caspase molecules in dogs containing separate domains related to human caspase-1 and -4. The canine caspase-1/4 hybrid lacked the LPS-sensing ability of human caspase-4 but retained the…

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    • A new @BostonChildrens, @harvardmed study of the caspase #enzyme in #dogs and #cats inspired researchers to engineer modifications into human caspases that allow one caspase to act as two. The results could help inform the design of new #immune pathways: https://t.co/XjQgv0Vlii

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    Caspases are innate immune enzymes that regulate activation of inflammasomes and cell death occurring via pyroptosis. Devant et al . investigated the biological activity of naturally occurring hybrid caspase molecules in dogs containing separate domains related to human caspase-1 and -4. The canine caspase-1/4 hybrid lacked the LPS-sensing ability of human caspase-4 but retained the…

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    • By studying caspase enzymes in #dogs and #cats and assessing how they compare to human caspases, @jkagan1 and @BostonChildrens, @harvardmed scientists illustrate the natural flexibility of caspase proteins and how they foster multiple #immune pathways: https://t.co/YZ8mWR4Hxg https://t.co/1Z9xfOjQOg