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Mashup Score: 11GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation - Nature Cardiovascular Research - 1 year(s) ago
Using various mouse models, human plaque data and isolated B cells combined with state-of-the-art imaging and transcriptomic analysis, the authors show that the G-protein-coupled orphan receptor GPR55 regulates B cell activation and plasma cell differentiation during hypercholesterolemia, which crucially affects atherosclerosis.
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0Ezh2 Represses Transcription of Innate Lymphoid Genes in B Lymphocyte Progenitors and Maintains the B-2 Cell Fate - 1 year(s) ago
Key Points. Ezh2 is required for repression of ILC2 transcription factors in pro-B lymphocytes.Lin28b is expressed in Ezh2-deficient pro-B lymphocytes.Ezh2 limi
Categories: Allergy-Immunology, Latest HeadlinesTweet-
#ICYMI from @BarbaraLKee @UCCancerCenter @UChicagoImmuno @UChicago | Ezh2 Represses #Transcription of Innate Lymphoid #Genes in B #Lymphocyte #Progenitors and Maintains B2 Cell Fate #ReadtheJI #Bcells #CellDevelopment https://t.co/988BnypQJ4 https://t.co/PRaogTEsZV
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Mashup Score: 0CD4+ T-cell cooperation promoted pathogenic function of activated naïve B cells of patients with SLE - 2 year(s) ago
Objective To explore cooperation between activated naïve (aNAV) B cells and CD4+ T cells in the pathogenesis of SLE through autoantibody production, T-cell differentiation and inflammatory cytokine secretion. Methods Peripheral blood mononuclear cell samples were obtained from 31 patients with SLE and used to characterise phenotype of aNAV B cells (n=14) and measured the phosphorylation of…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet-
#immunology Study show that #Bcells, w/ upregulated #Tcell #costimulatory & FCRL5 molecules, responded to BCR ligation leading to the activation of PLCγ2 #signaling. BCR & #TLR7/TLR8 signals, promoted #CD4+ Tcell proliferation & polarization to #Th2 &#Th17 https://t.co/uRTsRMEEgA
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Mashup Score: 1CD4+ T-cell cooperation promoted pathogenic function of activated naïve B cells of patients with SLE - 2 year(s) ago
Objective To explore cooperation between activated naïve (aNAV) B cells and CD4+ T cells in the pathogenesis of SLE through autoantibody production, T-cell differentiation and inflammatory cytokine secretion. Methods Peripheral blood mononuclear cell samples were obtained from 31 patients with SLE and used to characterise phenotype of aNAV B cells (n=14) and measured the phosphorylation of…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet-
#immunology Study show that #Bcells, w/ upregulated #Tcell #costimulatory & FCRL5 molecules, responded to BCR ligation leading to the activation of PLCγ2 #signaling. BCR & #TLR7/TLR8 signals, promoted #CD4+ Tcell proliferation & polarization to #Th2 &#Th17 https://t.co/uRTsRMn3p2
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Mashup Score: 0Immune complex–driven neutrophil activation and BAFF release: a link to B cell responses in SLE - 2 year(s) ago
Objective The role of neutrophils in driving pathogenic B cell responses in SLE is not fully understood. In this study, we explored the link between immune complex (IC)–driven neutrophil activation, the release of B cell pro-survival factor BAFF and B cell activation using SLE clinical samples. Methods BAFF levels were analysed in serum samples from patients with SLE (n=60) and healthy controls…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet-
This week on LSM: Stimulation of #neutrophils with #SLE-relevant RNP/IgG #immune #complexes induces the release of BAFF. Approaches targeting interactions between PMNs & #Bcells could help inhibit #pathogenic B cell #responses in #patients with #Lupus https://t.co/U1Nqm8tPkI
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Mashup Score: 0Immune complex–driven neutrophil activation and BAFF release: a link to B cell responses in SLE - 2 year(s) ago
Objective The role of neutrophils in driving pathogenic B cell responses in SLE is not fully understood. In this study, we explored the link between immune complex (IC)–driven neutrophil activation, the release of B cell pro-survival factor BAFF and B cell activation using SLE clinical samples. Methods BAFF levels were analysed in serum samples from patients with SLE (n=60) and healthy controls…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet-
This week on LSM: Stimulation of #neutrophils with #SLE-relevant RNP/IgG #immune #complexes induces the release of BAFF. Approaches targeting interactions between PMNs & #Bcells could help inhibit #pathogenic B cell #responses in #patients with #Lupus https://t.co/U1Nqm8tPkI
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Mashup Score: 7Contents | Science Immunology 7, 74 - 2 year(s) ago
Science Immunology Volume 7|Issue 74|Aug 2022 ONLINE COVER Exclusion of CD45 from a CAR-T Synapse. This month’s cover features a confocal microscopy image in which a human T cell expressing a CD19-targeting chimeric antigen receptor (CAR), stained in red, has formed an immunological synapse with a human Raji B cell lymphoma cell (blue). CD45 (green), a bulky tyrosine…
Source: Science ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
The August issue of Science #Immunology is out! The cover study examines CAR T activation and protein size. Other research spotlights autoreactive #Bcells and exhausted #Tcells. Read more⤵️ https://t.co/pR7Xb1oWxg https://t.co/xVk7ndovQX
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Mashup Score: 0Immune complex–driven neutrophil activation and BAFF release: a link to B cell responses in SLE - 2 year(s) ago
Objective The role of neutrophils in driving pathogenic B cell responses in SLE is not fully understood. In this study, we explored the link between immune complex (IC)–driven neutrophil activation, the release of B cell pro-survival factor BAFF and B cell activation using SLE clinical samples. Methods BAFF levels were analysed in serum samples from patients with SLE (n=60) and healthy controls…
Source: Lupus Science & MedicineCategories: Latest Headlines, RheumatologyTweet-
This week on LSM: Stimulation of #neutrophils with #SLE-relevant RNP/IgG #immune #complexes induces the release of BAFF. Approaches targeting interactions between PMNs & #Bcells could help inhibit #pathogenic B cell #responses in #patients with #Lupus https://t.co/U1Nqm8tPkI
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Mashup Score: 0Call for Papers - 2 year(s) ago
Special Issue: Human B cells Guest Editors: Mats Bemark, University of Gothenburg, Thomas Tull, King’s College London/ Guy’s and St Thomas’ NHS Trust
Source: Oxford AcademicCategories: General Medicine News, Latest HeadlinesTweet-
Don’t miss out on your chance to publish in the upcoming Special Issue from @CEIjournal on human #Bcells. Submissions are welcome until 31 July 2022. Submit now. @britsocimm https://t.co/frM11cl9Ff https://t.co/SaXDbh1jew
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Mashup Score: 2Call for Papers - 2 year(s) ago
Special Issue: Human B cells Guest Editors: Mats Bemark, University of Gothenburg, Thomas Tull, King’s College London/ Guy’s and St Thomas’ NHS Trust
Source: Oxford AcademicCategories: General Medicine News, Latest HeadlinesTweet-
.@CEIjournal is currently welcoming original research, perspectives and mini-reviews for an upcoming Special Issue on human #Bcells. Submissions are welcome until 31 July 2022. Submit now. @britsocimm https://t.co/SKWDEEyi8C https://t.co/ubLmPh7bfL
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Atherosclerosis: How the body controls the activity of #Bcells https://t.co/uEzlOFxEtb https://t.co/yhMwo9zXr0