-
Mashup Score: 0The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis - 3 year(s) ago
Author summary The actin cytoskeleton is a collection of protein polymers that assemble and disassemble within cells at specific times and locations. Cytoskeletal regulators called nucleation factors ensure that actin polymerizes when and where it is needed, and many of these factors are members of the Wiskott-Aldrich Syndrome Protein (WASP) family. Humans express 8 WASP-family proteins, but…
Source: journals.plos.orgCategories: Genetics, Latest HeadlinesTweet
-
Mashup Score: 0Radium-223–induced Bystander Effects Cause DNA Damage and Apoptosis in Disseminated Tumor Cells in Bone Marrow - 3 year(s) ago
Radiation-induced bystander effects have been implicated in contributing to the growth delay of disseminated tumor cells (DTC) caused by 223RaCl2, an alpha particle–emitting radiopharmaceutical. To understand how 223RaCl2 affects the growth, we have quantified biological changes caused by direct effects of radiation and bystander effects caused by the emitted radiations on DTC and osteocytes….
Source: Molecular Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Radium-223 induced bystander effects cause DNA damage and #apoptosis in disseminated tumor cells in bone marrow highlighting the multifactorial impact of 223RaCl2 on the bone microenvironment. @CrianBanter @mjsikora https://t.co/VqojUEZA1V https://t.co/66Tu10yZCA
-
-
Mashup Score: 0
Summary: In this issue of Cancer Discovery , Pullarkat and colleagues present the results from a phase I clinical trial that is the first to combine small-molecule inhibitors for multiple antiapoptotic proteins, BCL2 as well as BCL-XL, with a traditional chemotherapy backbone for patients with relapsed/refractory acute lymphoblastic leukemia. This trial has demonstrated impressive response rates…
Source: Cancer DiscoveryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
In the Spotlight: Inhibiting the inhibitors of #apoptosis: when two targets are better than one by Karilyn Larkin & John Byrd. @OhioStateMed https://t.co/Uw8oHSm1z7 https://t.co/eUXO2P7FUe
-
-
Mashup Score: 0S100A6 represses Calu-6 lung cancer cells growth via inhibiting cell proliferation, migration, invasion and enhancing apoptosis - PubMed - 3 year(s) ago
S100 calcium binding protein A6 (S100A6) has been reported to involve in many kinds of cancers through regulating intracellular calcium homeostasis. Previous studies found that S100A6 increased in lung cancer patients’ plasma and pleural effusion. This study focused on its function in Calu-6 lung ca …
Source: PubMedCategories: Latest Headlines, PulmonologyTweet-
#S100A6 represses Calu-6 #lung #cancer cells growth via #inhibiting #cell #proliferation, migration, invasion and enhancing #apoptosis #LungCancer https://t.co/ngehpH9yKe https://t.co/2jOjpMTbvS
-
-
Mashup Score: 0Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis - 3 year(s) ago
Celastrol might be useful in treating rheumatoid arthritis in part by inhibiting apoptosis of macrophages; however, systemic toxicity is a concern. Here the authors design celastrol-loaded nanoparticles that release a payload in response to MMP9 cleavage and show these NPs are effective at inducing apoptosis of human macrophages in vitro and a therapeutic effect with an adjuvant-induced arthritis…
Source: Nature CommunicationsCategories: Latest Headlines, RheumatologyTweet-
#ResearchHighlight | Inducing #apoptosis in joint cells improves advanced #arthritis Read the original research from @NatureComms here https://t.co/jX5H6lJC4q Read our #news story here https://t.co/TysKF7XCN9
-
-
Mashup Score: 0During infancy low levels of follicle-stimulating hormone may result in high rate of germ cell apoptosis - 3 year(s) ago
It has been suggested that follicle-stimulating hormone (FSH) plays a role in preventing germ cell apoptosis. We aimed to compare apoptotic rate of boys with cryptorchidism having different levels of FSH in order to investigate its role in apoptosis.
Source: Journal of Pediatric SurgeryCategories: Latest Headlines, PediatricsTweet-
During infancy low levels of follicle-stimulating hormone may result in high rate of germ cell apoptosis https://t.co/9GsB3lUAR1 #SoMe4PedSurg #jpedsurg #PediatricSurgery #PrognosisStudy #Cryptorchidism #Apoptosis #Gonocytetransformation #Folliclestimulatinghormone https://t.co/cETC1Tzibw
-
-
Mashup Score: 0STING enhances cell death through regulation of reactive oxygen species and DNA damage - 3 year(s) ago
The endoplasmic reticulum-localized adaptor STING regulates the innate immune response through its ability to sense DNA damage. Here the authors reveal that STING functions as a regulator of cellular ROS homeostasis and tumor cell susceptibility to reactive oxygen dependent, DNA damaging agents.
Source: Nature CommunicationsCategories: Hem/Oncs, Latest HeadlinesTweet-
Cool new science about #STING = STimulator of INterferon Genes, which enhance tumor cell death in response to DNA damage, @NatureComms https://t.co/O5p8C6vRiG? @YaleCancer #apoptosis
-
-
Mashup Score: 0
While immune responses induced by bacterial infection may be leveraged to fight cancer, few bacterial proteins have been investigated for anticancer potential. Here, the bacterial protein and virulen…
Source: Wiley Online LibraryCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
NOW ONLINE | New study from @Ucmr_sweden & @ICMRNICED by Aftab Nadeem @aftabnadeem18, Kyaw Min Aung, Tanusree Ray, et al. Read it here - #openaccess ➡️https://t.co/iPmgR6PROh #βcatenin #ColorectalCancer #apoptosis #VibrioCholerae @umeauniversitet https://t.co/htfz0Op4Xf
-
-
Mashup Score: 0Oral microbiome interactions with gingival gene expression patterns for apoptosis, autophagy and hypoxia pathways in progressing periodontitis - 3 year(s) ago
Local gingival environmental changes occur in the transition from periodontal health to disease. These changes impact both the microbiome at these sites and the juxtaposed gingival tissues. This stud…
Source: Wiley Online LibraryCategories: Allergy-Immunology, Latest HeadlinesTweet-
Oral #microbiome interactions with gingival gene expression patterns for #apoptosis, #autophagy & hypoxia pathways in progressing #periodontitis Jeffrey Ebersole et al. @unlv (£)https://t.co/pmxkTwSeMZ https://t.co/hGL679Rhj6
-
-
Mashup Score: 1Systematic review of cognitive impairment and brain insult after mechanical ventilation - 3 year(s) ago
We conducted a systematic review following the PRISMA protocol primarily to identify publications that assessed any links between mechanical ventilation (MV) and either cognitive impairment or brain insult, independent of underlying medical conditions. Secondary objectives were to identify possible gaps in the literature that can be used to inform future studies and move toward a better…
Source: Critical CareCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OA #Mechanical_ventilation & acute #cognitive_impairment: any association? https://t.co/us9tU3qAWD #FOAMed #FOAMcc #BMC #ICU #Brain #brain_injury #delirium #apoptosis @ISICEM @jlvincen https://t.co/0GCPrCuDD4
-
How does the actin #cytoskeleton impact programmed cell death? King et al find that two WASP-family genes are necessary for rapid apoptotic responses 📰https://t.co/EYV820xW30 📷 human osteosarcoma cell undergoing #DNA damage-induced #apoptosis - #CCBY https://t.co/OTSzekQXLb