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Mashup Score: 1Hallmarks of Cancer: New Dimensions - 2 year(s) ago
AbstractThe hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity of cancer phenotypes and genotypes into a provisional set of underlying principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and disrupted differentiation is a…
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2Volume 22 Issue 1, January 2022 - 2 year(s) ago
Volume 22 Issue 1, January 2022
Source: www.nature.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Happy new year everybody! Start 2022 with browsing our Jan issue: cancer-focused Reviews on targeting #transcription cycles, overcoming #TGFβ-mediated immune evasion, and manipulating #apoptosis using #BH3-mimetic drugs! 💌 https://t.co/bhA8FyE9TB @natrescancer #CancerTherapy https://t.co/rJGs8NFy9N
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Mashup Score: 0Autophagic degradation of IRF3 induced by the small-molecule auranofin inhibits its transcriptional and proapoptotic activities - 2 year(s) ago
The ubiquitously expressed transcription factor interferon (IFN) regulatory factor 3 (IRF3) is critical for the induction of antiviral genes, e.g., type-I IFN. In addition to its transcriptional function, IRF3 also activates a nontranscriptional, proapoptotic signaling pathway. While the proapoptotic function of IRF3 protects against viral infections, it is also involved in harmful immune…
Source: Journal of Biological ChemistryCategories: Allergy-Immunology, Latest HeadlinesTweet-
Glanz et al. find auranofin is a novel inhibitor of IRF3 functions and may represent a potential therapeutic option in diseases where IRF3 is deleterious — @UToledoMed #apoptosis #IRF3 https://t.co/gg4CuzNBaG
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Mashup Score: 2
Background Multi-omics studies have shown a high and lack of common driver mutations in most thymomas (TH) and thymic carcinomas (TC) that hamper the development of novel treatment approaches. However, deregulation of apoptosis has been proposed as a common hallmark of TH and TC. BH3 profiling can be utilized to study the readiness of living cancer cells to undergo apoptosis and their dependency…
Source: BMC MedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Functional #apoptosis profiling identifies MCL-1 and BCL-xL as prognostic #markers and therapeutic targets in advanced #thymic carcinomas and #thymomas Read it here: https://t.co/ozGwasCOWd https://t.co/JQlo1Msehd
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Mashup Score: 4Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis - 3 year(s) ago
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive leukemia of plasmacytoid dendritic cells (pDCs). BPDCN occurs at least three times more frequently in men than women, but the reasons for this sex bias are unknown. Here, studying genomics of primary BPDCN and modeling disease-associated mutations, we link acquired alterations in RNA splicing to abnormal pDC development and…
Source: Cancer DiscoveryCategories: Hem/Oncs, Latest HeadlinesTweet-
#ZRSR2 mutations in myeloid as malignancies impair #plasmacytoid dendritic cell activation and #apoptosis https://t.co/yalZDG4OkO | Togami & @lane_andy || @TaylorJ_MD @mkonople @doctorpemm @AbdelWahablab @ElizSMcKenna @CD_AACR #BPDCN #leusm https://t.co/QS5dsYX6uM
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Mashup Score: 25The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs - Nature Reviews Cancer - 3 year(s) ago
BH3-mimetic drugs have been designed to directly induce apoptosis in cancer cells by targeting prosurvival BCL-2 family proteins. This Review discusses their continued development and the challenges arising from their implementation in the clinic, such as resistance or on-target toxic effects, and the approaches that could be harnessed to overcome these obstacles.
Source: Nature Reviews CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
NEW Review! Andreas Strasser , Gemma L. Kelly et al. discuss the manipulation of #apoptosis for cancer therapy using #BH3-mimetic drugs. ⚡https://t.co/x9Op9qwqCw @natrescancer @WEHI_research #CancerTherapy #TherapyResistance https://t.co/qTMxf6eoTn
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Mashup Score: 0
Background Acute brain injuries are associated with high mortality rates and poor long-term functional outcomes. Measurement of cerebrospinal fluid (CSF) biomarkers in patients with acute brain injuries may help elucidate some of the pathophysiological pathways involved in the prognosis of these patients. Methods We performed a systematic search and descriptive review using the MEDLINE database…
Source: Critical CareCategories: Critical Care, Latest HeadlinesTweet-
#CritCare #OA #Cerebrospinal_fluid #biomarkers for #acute_brain_injuries https://t.co/pSygWxOu2X #FOAMed #FOAMcc #BMC @ISICEM @jlvincen #CSF #cytoskeleton #inflammation #apoptosis #oxidative_stress #hemorrhage #neurology https://t.co/kimmmAGdTb
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Mashup Score: 2The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core - Nature Communications - 3 year(s) ago
The pro-apoptotic BAX protein is a monomer under homeostatic conditions and, in response to stress, transforms into oligomers that induce apoptosis. Here, the authors characterize structural features of BAX that individually stabilize the monomer while collectively contributing to oligomerization.
Source: Nature CommunicationsCategories: Latest Headlines, Oncologists1Tweet-
Working hard to unravel the mysteries of BAX, a protein with the power to kill damaged and defective cells - including cancer! Congrats to our entire team on this latest work. @Noah_B_Bloch @jrengen @tmonsterphd @NatureComms #apoptosis https://t.co/2QpgYnJX7z
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Mashup Score: 2TMEM100 negatively regulated by microRNA‑106b facilitates cellular apoptosis by suppressing survivin expression in NSCLC - PubMed - 3 year(s) ago
Non‑small cell lung cancer (NSCLC) is a common malignant tumour. Nevertheless, the 5‑year survival rate of NSCLC patients remains poor. Thus, identifying critical factors involved in regulating the progression of NSCLC is important for providing potential treatment targets. In the present study, it …
Source: PubMedCategories: Latest Headlines, PulmonologyTweet-
#TMEM100 negatively regulated by #microRNA‑ #106b facilitates #cellular #apoptosis by suppressing #survivin expression in #NSCLC #LungCancer https://t.co/ZsCttcNdfE https://t.co/2NbpJYBFtk
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Mashup Score: 0Pharmacological inhibition of adipose tissue adipose triglyceride lipase by Atglistatin prevents catecholamine-induced myocardial damage - 3 year(s) ago
AbstractAims. Heart failure (HF) is characterized by an overactivation of β-adrenergic signalling that directly contributes to impairment of myocardial function
Source: OUP AcademicCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Thinking outside of the #heart New study finds Atglistatin inhibition of #adipose triglyceride lipase ⬇️myocardial #fibrosis, #apoptosis, & #fattyacid secretion, to protect against #HeartFailure https://t.co/XDrVe4FK2H @CVR_TomaszGuzik @glenpyle #HFpEF #CardiovascularResearch https://t.co/IAYvN8tcnz
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Original Hallmark: Resisting cell death: malignant cells are able to overcome the barrier of #apoptosis allowing continued expansion. https://t.co/GlMKYTvGNX #HallmarksofCancer https://t.co/9EJeXTnkC2