• Mashup Score: 5
    Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction - 8 month(s) ago

    Adhikary et al. report that MCL-1 regulates cell proliferation and DNA integrity independent from its role in apoptosis suppression. Genetic deletion or pharmacologic targeting has a striking anti-proliferative effect, informing opportunities to expand the utility of MCL-1 inhibitors in cancer as single agents and in combinations, but with heightened precautions.

    Source: www.cell.com
    Categories: Latest Headlines, Oncologists1
    Tweet Tweets with this article
    • Profile photo of LorenWalensky
      LorenWalensky

      New revelations about MCL-1, a formidable protein that drives human cancer & a challenging therapeutic target due to its multifaceted roles. Kudos to @ImTitoA for first-authoring this enormous body of work. @CellReports @theNCI @DanaFarber @BBS_Harvard https://t.co/bA8dZRt4x0

  • Mashup Score: 1
    Walensky Running Buffers 2023 - 8 month(s) ago

    The Walensky Laboratory comprises a multidisciplinary group of young scientists, training as Dana-Farber Cancer Institute postdoctoral fellows in pediatric oncology, graduate students in the chemical

    Source: www.alexslemonade.org
    Categories: Latest Headlines, Oncologists1
    Tweet Tweets with this article
    • Profile photo of LorenWalensky
      LorenWalensky

      The Volvo Match is back on from September 27-30! Your donation to support pediatric cancer research will be automatically doubled! Please consider donating to our lab team’s fundraiser link today through Saturday: https://t.co/A6twbYIVjL Thank you! 🙏 https://t.co/IBFprkmZv6

  • Mashup Score: 3
    Walensky Running Buffers 2023 - 8 month(s) ago

    The Walensky Laboratory comprises a multidisciplinary group of young scientists, training as Dana-Farber Cancer Institute postdoctoral fellows in pediatric oncology, graduate students in the chemical

    Source: www.alexslemonade.org
    Categories: Hem/Oncs, Latest Headlines
    Tweet Tweets with this article
    • Profile photo of LorenWalensky
      LorenWalensky

      Final hours to have your donation to Alex’s Million Mile in support of pediatric cancer research DOUBLED by @volvocars ! Please donate & double your impact today, Sunday Sep 17, up until midnight at our link below and help us fight to end pediatric cancer: https://t.co/A6twbYIVjL

  • Mashup Score: 3
    Studying the Past to Understand the Present - 1 year(s) ago

    MD-PhD grad Alyssa Botelho embarks on career as physician, social scientist

    Source: hms.harvard.edu
    Categories: Hem/Oncs, Latest Headlines
    Tweet Tweets with this article
    • Profile photo of LorenWalensky
      LorenWalensky

      A must read profile on the amazing @HarvardMITmdphd soon-to-be-grad Alyssa Botelho @AlyssaABotelho physician social-scientist extraordinaire. Oh the Places You’ll Go! So proud of you and all that you have and will accomplish. https://t.co/iZcUDp5XBq

  • Mashup Score: 1
    Home - Alex's Team - 2 year(s) ago

    The Alex’s Team Foundation is a non-profit organization that fights childhood cancer by funding pioneering programs in pediatric oncology research, education, and care.

    Source: Alex's Team
    Categories: Hem/Oncs, Latest Headlines
    Tweet Tweets with this article
    • Profile photo of LorenWalensky
      LorenWalensky

      Tonight we honor the life & legacy of Alex Miliotis at the Alex’s Team Spirit Ball - marking 20 years since her life was cut short by leukemia. The foundation invests in the next generation of nurses, doctors & scientists who will fight pediatric cancer. https://t.co/zXPmf8uwRI https://t.co/WsTZjoLHBV

  • Mashup Score: 7
    MCL-1 is a master regulator of cancer dependency on fatty acid oxidation - 2 year(s) ago

    Prew et al. report that, independent of its anti-apoptotic function, MCL-1 enforces a programmatic dependency on fatty acid oxidation (FAO) in MCL-1-driven hematologic cancer cells, rendering them vulnerable to FAO inhibition. Mcl-1 deletion broadly downregulates the FAO pathway, revealing MCL-1 as a master regulator of fatty acid metabolism.

    Source: Cell Reports
    Categories: Latest Headlines, Oncologists1
    Tweet Tweets with this article
    • Profile photo of LorenWalensky
      LorenWalensky

      Congrats to Walensky lab grad Michelle Prew @prewmi on the publication of her PhD research that revealed MCL-1 is a master regulator of cancer dependency on fatty acid oxidation, with key therapeutic implications! @DanaFarber @BBS_Harvard @LLSusa @theNCI https://t.co/uirSQE2Wva

  • Mashup Score: 0
    Walensky Running Buffers 2022 - 2 year(s) ago

    The Walensky Laboratory comprises a multidisciplinary group of young scientists, training as Dana-Farber Cancer Institute postdoctoral fellows in pediatric oncology, graduate students in the chemical and biological sciences graduate programs at Harvard Medical School, and post-baccalaureate research technicians. Our mission is to dissect and target the aberrant molecular pathways that cause…

    Source: Alex's Lemonade Stand Foundation for Childhood Cancer
    Categories: Hem/Oncs, Latest Headlines
    Tweet Tweets with this article
    • Profile photo of LorenWalensky
      LorenWalensky

      Help support pediatric cancer research by making your donation today: https://t.co/fk2vTxgN7z and from September 8-11, @VolvoCarUSA will double the value of your donation for double the impact!

Load More