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    ArticlesEarly T cell and binding antibody responses are associated with COVID-19 RNA vaccine efficacy onsetMedIn Press, Corrected ProofPublished online: April 8, 2021Shirin KalimuddinChristine Y.L. ThamMartin QuiRuklanthi de AlwisJean X.Y. SimJoey M.E. Limand othersKalimuddin et al. show that spike protein-binding antibodies and spike-specific T cells, but not neutralizing antibodies, could…

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    The full potential of T cell-based immunotherapies remains limited by a variety of T cell extrinsic and intrinsic immunosuppressive mechanisms that can become imprinted to stably reduce the antitumor ability of T cells. Here, we discuss recent insights into memory CD8+ T cell differentiation and exhaustion and the association of these differentiation states with clinical outcomes during immune…

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    • Read the Opinion @TrendsImmuno by Caitlin C. Zebley, Stephen Gottschalk & Ben Youngblood, Rewriting History: #Epigenetic Reprogramming of #CD8+ #TCell #Differentiation to Enhance #Immunotherapy @CellCellPress #AAI2021 https://t.co/i1Al9nAsgr #immunology

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    In recent years, cancer immunotherapy has become a pillar in the treatment of cancer. Hegde and Chen discuss the top ten challenges facing this field, including the opportunity to optimize both synthetic and endogenous immune approaches and to target different immune suppressive mechanisms specific for each patient with cancer.

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    • ICYMI: Great Perspective from @DanChenMDPhD & @PritiHegde: "Top 10 Challenges in #Cancer #Immunotherapy" | Discusses the top 10 challenges facing this field & what is necessary to overcome them https://t.co/a076C90yxB #AAI2021 #immunology

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    Immunity: Cell Press - 3 year(s) ago

    Immunity publishes peer-reviewed papers that report the most important advances in immunology research.

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    • Read our special focus issue on interactions & identity in the #tumor microenvironment | Reviews from @MiriamMerad @TurleyLabGNE Andrew Luster & Jeffrey Pollard &co https://t.co/hgSho6hCTv #cancer #AAI2021 #immunology https://t.co/QvSl4UPaTw