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Mashup Score: 0Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions - 1 year(s) ago
The induction of bNAbs is essential for a protective HIV-1 vaccine, but current vaccines are unable to induce sufficient B cell maturation. Caniels et al. describe an immunization regimen that elicits neutralizing antibodies toward the CD4bs and isolates monoclonal antibodies with rare sequence features that resemble bNAbs.
Source: Cell Reports MedicineCategories: Infectious Disease, Latest HeadlinesTweet
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Mashup Score: 6
Diaz-Canestro et al. identify circulating proteins that predict the metabolic responsiveness to exercise training in individuals with prediabetes. These findings may facilitate the clinical implementation of personalized exercise interventions for diabetes prevention.
Source: Cell Reports MedicineCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @statsepi: Gold medal for extreme noise mining here. Ht @metapredict https://t.co/gTvomQPEEo
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Mashup Score: 7
Nimgaonkar et al. describe the identification of a histologic signature derived using artificial intelligence that stratifies patients receiving adjuvant gemcitabine for pancreatic cancer. The signature is not associated with existing transcriptomic classification schemes and validates specifically to gemcitabine-treated patients in external cohorts.
Source: Cell Reports MedicineCategories: Healthcare Professionals, Latest HeadlinesTweet-
10/ Read more in our paper here: https://t.co/16fWSEKC2k Effort continues... https://t.co/F574xlbGxc
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1/ 📢 New paper alert! Pancreatic cancer lacks actionable biomarkers for precision therapy. We developed an AI-derived histologic signature that can predict treatment outcomes for a specific chemotherapy from pancreatic tumor resections. https://t.co/16fWSEKC2k Key points ⬇️
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Mashup Score: 3
Nimgaonkar et al. describe the identification of a histologic signature derived using artificial intelligence that stratifies patients receiving adjuvant gemcitabine for pancreatic cancer. The signature is not associated with existing transcriptomic classification schemes and validates specifically to gemcitabine-treated patients in external cohorts.
Source: Cell Reports MedicineCategories: Hem/Oncs, Latest HeadlinesTweet-
From @valarlabs @PancPathologist and colleagues in @CellRepMed Development of an artificial intelligence-derived histologic signature associated with adjuvant gemcitabine treatment outcomes in #PancreaticCancer https://t.co/gOzqHyh085 https://t.co/pQUYQSpdVm
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Mashup Score: 4USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities - 1 year(s) ago
Perurena et al. show that PDACs are resistant to MEK inhibitors because they trigger the formation of USP9X:Mcl-1 complexes, thereby acutely stabilizing Mcl-1 and inhibiting apoptosis. Resistance can be overcome by targeting Mcl-1 with direct inhibitors or by suppressing Mcl-1 transcription with CDK inhibitors, revealing new therapeutic strategies for PDAC.
Source: Cell Reports MedicineCategories: Hem/Oncs, Latest HeadlinesTweet-
#OpenAccess in @CellRepMed from @DanaFarber_Hale colleagues: USP9X mediates an acute adaptive response to MAPK suppression in #PancreaticCancer but creates multiple actionable therapeutic vulnerabilities https://t.co/FEYgkJVGdJ https://t.co/dg3otrwQkC
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Mashup Score: 0Brief structured respiration practices enhance mood and reduce physiological arousal - 1 year(s) ago
In a remotely conducted randomized controlled trial, Yilmaz Balban et al. study the psychophysiological effects of controlled breathwork compared with mindfulness meditation. Breathwork produces greater improvement in mood and reduction in respiratory rate, while both result in reduction in negative emotion including state anxiety.
Source: Cell Reports MedicineCategories: Healthcare Professionals, Latest HeadlinesTweet-
Le sigh! Daily 5-min cyclic sighing has promise as an effective stress management exercise Breathwork, especially cyclic sighing, caused better mood and lower respiratory rate than mindfulness meditation. https://t.co/uzSL6pOmQc
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Mashup Score: 0PD-1 blockade plus chemoradiotherapy as preoperative therapy for patients with BRPC/LAPC: A biomolecular exploratory, phase II trial - 1 year(s) ago
Du et al. show the efficacy, safety, and predictive biomarkers of PD-1 blockade plus chemotherapy followed by concurrent SBRT with SIB as preoperative therapy for LAPC and BRPC. They report that ctDNA dynamic changes or continuous CA19-9 decline may predict tumor response and survival outcomes.
Source: Cell Reports MedicineCategories: Hem/Oncs, Latest HeadlinesTweet-
Good to see @CellRepMed as another home for exploratory clinical trials with liquid Bx correlatives. PD-1 blockade plus chemoradiotherapy as preoperative therapy for patients with BR/LA #PancreaticCancer: a biomolecular exploratory, phase II trial https://t.co/VElUmgLutL https://t.co/cUnqkcu2Pn
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Mashup Score: 31Multi-organ single-cell analysis reveals an on/off switch system with potential for personalized treatment of immunological diseases - 1 year(s) ago
Lilja et al. report that treating immune diseases is complicated by involvement of thousands of genes. Combined analyses of mouse arthritis and human immune diseases show organome-, cellulome-, and genome-wide changes, which are switched on or off by pro- or anti-inflammatory upstream regulators (URs). Targeting URs may contribute to personalized medicine.
Source: Cell Reports MedicineCategories: Expert Picks, Latest HeadlinesTweet-
Finding digital biological twins via deep phenotyping is an emerging strategy to individualize medical treatment. Here's the first crack at using this for autoimmune diseases https://t.co/qXj8QzzUWt @CellRepMed @karolinskainst https://t.co/c8tStzRVPu
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Mashup Score: 1
Diaz-Canestro et al. identify circulating proteins that predict the metabolic responsiveness to exercise training in individuals with prediabetes. These findings may facilitate the clinical implementation of personalized exercise interventions for diabetes prevention.
Source: Cell Reports MedicineCategories: General Medicine News, Latest HeadlinesTweet-
"A machine learning algorithm integrating baseline serum proteomic signatures predicts exercise responsiveness in overweight males with prediabetes" @hkumed Aimin Xu Michael, Andrew Tse Read more in @CellRepMed: https://t.co/uwFRviMWJu
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Mashup Score: 3Deep generative molecular design reshapes drug discovery - 1 year(s) ago
Deep generative models hold great promise as powerful approaches for drug design. Zeng et al. review the current deep generative models and their applications in discovering small molecules and macromolecules, discuss the data and technical challenges, and highlight future directions in improving deep generative models for drug discovery communities.
Source: Cell Reports MedicineCategories: General Medicine News, Latest HeadlinesTweet-
Check out this review by @FeixiongCheng @ClevelandClinic & colleagues "Deep generative molecular design reshapes drug discovery" @CellRepMed #bps2023 https://t.co/P7sRHjxQWP
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Overcoming barriers in HIV-1 vaccine development! Collaborators alongside Dr. Rogier Sanders of @amsterdamumc have developed a strategy to target germline precursors of broadly neutralizing antibodies using a novel trimer. 📘 @CellRepMed 📑 https://t.co/gsB0ORsc1r https://t.co/YG14fvRlke