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Mashup Score: 15
Taking more steps per day was associated with a progressively lower risk of all-cause mortality, up to a level that varied by age. The findings from this meta-analysis can be used to inform step guidelines for public health promotion of physical activity.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 3Air pollution exposure and cardiometabolic risk - 13 hour(s) ago
The Global Burden of Disease assessment estimates that 20% of global type 2 diabetes cases are related to chronic exposure to particulate matter (PM) with a diameter of 2·5 μm or less (PM2·5). With 99% of the global population residing in areas where air pollution levels are above current WHO air quality guidelines, and increasing concern in regard to the common drivers of air pollution and climate change, there is a compelling need to understand the connection between air pollution and cardiometabolic disease, and pathways to address this preventable risk factor.
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 655Air pollution exposure and cardiometabolic risk - 18 hour(s) ago
The Global Burden of Disease assessment estimates that 20% of global type 2 diabetes cases are related to chronic exposure to particulate matter (PM) with a diameter of 2·5 μm or less (PM2·5). With 99% of the global population residing in areas where air pollution levels are above current WHO air quality guidelines, and increasing concern in regard to the common drivers of air pollution and climate change, there is a compelling need to understand the connection between air pollution and cardiometabolic disease, and pathways to address this preventable risk factor.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 105
In this prespecified pooled analysis of the STEP-HFpEF and STEP-HFpEF DM trials, semaglutide was superior to placebo in improving heart failure-related symptoms and physical limitations, and reducing bodyweight in participants with obesity-related heart failure with preserved ejection fraction. These effects were largely consistent across patient demographic and clinical characteristics. Semaglutide was well tolerated.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 86Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants - 21 hour(s) ago
Patients with germline SDHD pathogenic variants (encoding succinate dehydrogenase subunit D; ie, paraganglioma 1 syndrome) are predominantly affected by head and neck paragangliomas, which, in almost 20% of patients, might coexist with paragangliomas arising from other locations (eg, adrenal medulla, para-aortic, cardiac or thoracic, and pelvic). Given the higher risk of tumour multifocality and bilaterality for phaeochromocytomas and paragangliomas (PPGLs) because of SDHD pathogenic variants than for their sporadic and other genotypic counterparts, the management of patients with SDHD PPGLs is clinically complex in terms of imaging, treatment, and management options.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 3A proposed clinical classification for pituitary neoplasms to guide therapy and prognosis - 22 hour(s) ago
No comprehensive classification system that guides prognosis and therapy of pituitary adenomas exists. The 2022 WHO histopathology-based classification system can only be applied to lesions that are resected, which represent few clinically significant pituitary adenomas. Many factors independent of histopathology provide mechanistic insight into causation and influence prognosis and treatment of pituitary adenomas. We propose a new approach to guide prognosis and therapy of pituitary adenomas by integrating clinical, genetic, biochemical, radiological, pathological, and molecular information for all adenomas arising from anterior pituitary cell lineages.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 111Moderna stalls on African vaccine manufacturing plans - 23 hour(s) ago
Moderna’s decision has been criticised by the Africa CDC, with experts urging countries to invest domestically. Paul Adepoju reports.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet-
"Moderna is abandoning a commitment to build highly needed and relevant vaccine manufacturing capabilities in Africa" The Africa CDC has criticised Moderna's decision to pause plans for an mRNA vaccine manufacturing plant in Kenya. @pauladepoju reports. https://t.co/ESRmCDIRuS https://t.co/XeRbyp1ne4
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Mashup Score: 44
Cyclic Cushing’s syndrome is a subentity of Cushing’s syndrome in which phases of biochemical hypercortisolism (peaks) are followed by spontaneous periods of physiological or even hypocortisolaemic cortisol secretion (troughs). To identify common features of cyclic Cushing’s syndrome, we systematically reviewed single case reports and case series in MEDLINE from database inception to Oct 10, 2022, and identified 707 articles, of which 149 articles were assessed for eligibility and 118 articles (covering 212 cases) were included in the analysis.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 3A proposed clinical classification for pituitary neoplasms to guide therapy and prognosis - 24 hour(s) ago
No comprehensive classification system that guides prognosis and therapy of pituitary adenomas exists. The 2022 WHO histopathology-based classification system can only be applied to lesions that are resected, which represent few clinically significant pituitary adenomas. Many factors independent of histopathology provide mechanistic insight into causation and influence prognosis and treatment of pituitary adenomas. We propose a new approach to guide prognosis and therapy of pituitary adenomas by integrating clinical, genetic, biochemical, radiological, pathological, and molecular information for all adenomas arising from anterior pituitary cell lineages.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 54Blood transcriptomic analyses reveal persistent SARS-CoV-2 RNA and candidate biomarkers in post-COVID-19 condition - 1 day(s) ago
With an estimated 65 million individuals affected by post-COVID-19 condition (also known as long COVID),1 non-invasive biomarkers are direly needed to guide clinical management. To address this pressing need, we used blood transcriptomics in a general practice-based case-control study. Individuals with long COVID were diagnosed according to WHO criteria, and validated clinical scales were used to quantify patient-reported outcomes.2 Whole blood samples were collected from 48 individuals with long COVID and 12 control individuals matched for age, sex, time since acute COVID-19, severity, vaccination status, and comorbidities (appendix 1 p 2).
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet
Taking more steps 👣 per day associated with a progressively lower risk of all-cause mortality. https://t.co/GFsxze2LvY https://t.co/Ll6SpXZ7af