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Mashup Score: 2
Both frailty (reduced physiological reserve) and social vulnerability (scarcity of adequate social connections, support, or interaction) become more common as people age and are associated with adverse consequences. Analyses of the relationships between these constructs can be limited by the wide range of measures used to assess them. In this systematic review, we synthesised 130 observational studies assessing the association between frailty and social vulnerability, the bidirectional longitudinal relationships between constructs, and their joint associations with adverse health outcomes.
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 22Effect of population-wide screening for presymptomatic early-stage type 1 diabetes on paediatric clinical care - 1 day(s) ago
Population-wide screening of children for presymptomatic early-stage type 1 diabetes is gaining momentum. Studies have demonstrated feasibility and acceptance, and shown that the rate of progression to clinical stage 3 diabetes is similar if islet autoantibody-positive early-stage type 1 diabetes is identified from general population or first-degree relative screening.1,2 Moreover, in conjunction with an education and follow-up package, screening significantly reduces the rates of ketoacidosis, symptoms, and hospitalisation.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 38Addressing labour exploitation in the global workforce - 1 day(s) ago
We applaud the 2023 Lancet Series on work and health for drawing attention to the under-recognised aspects of work that make it a fundamental social determinant of health inequalities. We particularly appreciate the Series authors’ attention to the low-wage workforce and their expressed concerns about precarity. At the same time, we must also be attuned to the widespread practice of labour exploitation, including extreme exploitation such as human trafficking and hazardous child labour. An estimated 21 million people are in trafficking, bonded, or slave labour situations.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 35
The markedly elevated rate of death in the first week post-release underscores an urgent need for investment in evidence-based, coordinated transitional healthcare, including treatment for mental illness and substance use disorders to prevent post-release deaths due to suicide and overdose. Temporal variations in rates and causes of death highlight the need for routine monitoring of post-release mortality.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 5
Melatonin, a hormone primarily produced by the brain’s pineal gland, is typically secreted during darkness, aligning with the time when most people sleep. Melatonin plays a crucial part in signalling the onset of the biological night. It achieves this through multiple mechanisms, including inhibiting wake-promoting orexin neurons located in the hypothalamus, which serves as a central hub for regulating the sleep–wake cycle.1 The fact that melatonin can help to regulate sleep timing might also explain its popularity, particularly in countries where it is available over the counter.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 36
With up to 23 years of follow-up of three large prospective cohorts of middle-aged and older men and women, self-reported melatonin supplement use was not associated with risk of type 2 diabetes or cardiovascular disease. Further research is warranted to assess if melatonin supplement use could mitigate the potential risks of type 2 diabetes and cardiovascular disease associated with rotating night shift work.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 23Methodological challenges in the development of endpoints for myelofibrosis clinical trials - 2 day(s) ago
Myelofibrosis is a myeloid neoplasm characterised by the presence of JAK2, CALR, or MPL mutations (with a 90% mutation frequency) and trilineage myeloid proliferation with prominent megakaryocyte atypia. People with myelofibrosis have a lower survival rate and poorer quality of life than healthy individuals. Therapy for myelofibrosis uses Janus kinase inhibitors, which reduce splenomegaly and alleviate symptoms. Regulatory approvals for Janus kinase inhibitors have focused on this dual endpoint.
Source: www.thelancet.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 42Prostate Cancer UK launches the TRANSFORM trial - 2 day(s) ago
TRANSFORM will recruit hundreds of thousands of men in an effort to identify the most effective screening strategies for prostate cancer. Talha Burki reports.
Source: www.thelancet.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 13
Launched as a public–private partnership funded by the Foundation for the National Institutes of Health, the Study to Advance Bone Mineral Density as a Regulatory Endpoint (SABRE) aims to change the framework for how clinical trials of new anti-osteoporosis drugs are conducted, to promote innovation in the field of osteoporosis, where underdiagnosis and undertreatment of disease have been deemed a crisis.1 Osteoporosis-related fractures, which lead to high morbidity and increased mortality, are a large and growing public health concern as one in two women and one in five men over the age of 50 years will have a fracture.
Source: www.thelancet.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 17
All tested dosing regimens blocked some infections to a similar degree. Improved vaccine efficacy in participants infected during vaccination could suggest new strategies for highly efficacious malaria vaccine development and implementation.
Source: www.thelancet.comCategories: General Medicine News, Infectious DiseaseTweet
The relationship between frailty and social vulnerability: a systematic review https://t.co/3VKCV3tI9y via @PHanlon17 et al