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Mashup Score: 12
Preclinical models that recapitulate aspects of human airway disease are essential for the advancement of novel therapeutics and vaccines. Here, we report a versatile airway organoid model, the human nose organoid (HNO), that recapitulates the complex …
Source: mBioCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 0Serological Markers of SARS-CoV-2 Reinfection | mBio - 2 year(s) ago
As public health and social distancing guidelines loosen in the setting of waning global natural and vaccine immunity, a deeper understanding of the immunological response to reexposure and reinfection to this highly contagious pathogen is necessary to …
Source: mBioCategories: Infectious Disease, Latest HeadlinesTweet-
What are the serological markers of #SARS-CoV-2 #reinfection? Dr. Galit Alter at the @ragoninstitute and colleagues used a rheus macque model to identify simple, rapid immune biomarkers of reinfection, including IgG3 antibody levels against nucleocapsid. https://t.co/p4haFlO5Ah https://t.co/AWSKCEw26g
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Mashup Score: 1
The vesicular stomatitis virus (VSV) vaccine platform rose to fame in 2019, when a VSV-based Ebola virus (EBOV) vaccine was approved by the European Medicines Agency and the U.S. Food and Drug Administration for human use against the deadly disease.
Source: mBioCategories: Infectious Disease, Latest HeadlinesTweet-
💉 @NIH scientists generated a single-dose, fast-acting vesicular stomatitis virus-based vaccine derived from the licensed #Ebola virus (EBOV) vaccine rVSV-ZEBOV, expressing the SARS-CoV-2 spike protein and the EBOV glycoprotein. https://t.co/SOwhFPZ1iq https://t.co/K16Rc46CM4
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Mashup Score: 1The Yersinia High-Pathogenicity Island Encodes a Siderophore-Dependent Copper Response System in Uropathogenic Escherichia coli | mBio - 2 year(s) ago
Interactions between bacteria and transition metal ions play an important role in encounters between humans and bacteria. Siderophore systems have long been prominent mediators of these interactions.
Source: mBioCategories: Infectious Disease, Latest HeadlinesTweet-
Iron shares the siderophore regulation spotlight! Graduate(d!) student @glkatumba found that extracellular copper stimulates yersiniabactin production as a third, virulence-associated, copper response system in E.coli. @mbiojournal @WUSTLdbbs @BBSBwustl https://t.co/qyoYpwzqKl https://t.co/knQtF4r2ed
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Mashup Score: 4Myeloid-Derived Suppressor Cells Mediate T Cell Dysfunction in Nonhuman Primate TB Granulomas | mBio - 2 year(s) ago
Myeloid cells are immunocytes of innate origin that orchestrate the first response toward pathogens via immune surveillance (uptake and killing), antigen presentation, and initiation of adaptive immunity by T cell stimulation. However, MDSCs are a subset …
Source: mBioCategories: Infectious Disease, Latest HeadlinesTweet-
✨ Today in @mBioJournal: Dr. Smriti Mehra's team at @TxBiomed used non-human primates to study myeloid-derived suppressor cells (MDSCs ) in latent and active #tuberculosis infections. 📃: https://t.co/zdDkqc8h2F https://t.co/CYBz70jVT6
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Mashup Score: 16Why Do Antibiotics Exist? | mBio - 2 year(s) ago
In the struggle with antibiotic resistance, we are losing. There is now a serious threat of moving into a postantibiotic world.
Source: mBioCategories: Infectious Disease, Latest HeadlinesTweet-
RT @ASMicrobiology: New minireview in @mBioJournal: Why Do Antibiotics Exist? https://t.co/9CRcBetWcs https://t.co/ZQmLihF2fp
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Mashup Score: 39Previous Infection Combined with Vaccination Produces Neutralizing Antibodies with Potency against SARS-CoV-2 Variants | mBio - 2 year(s) ago
As SARS-CoV-2 evolves to become better suited for circulating in humans, mutations have occurred in the spike protein it uses for attaching to cells it infects. Protective antibodies from prior infection or vaccination target the spike protein to …
Source: mBioCategories: General Medicine News, Latest HeadlinesTweet-
RT @EricTopol: A second study on this same topic today @mbiojournal https://t.co/HxApNRoM1k "When the persons with prior infection were su…
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Mashup Score: 30Previous Infection Combined with Vaccination Produces Neutralizing Antibodies with Potency against SARS-CoV-2 Variants | mBio - 2 year(s) ago
As SARS-CoV-2 evolves to become better suited for circulating in humans, mutations have occurred in the spike protein it uses for attaching to cells it infects. Protective antibodies from prior infection or vaccination target the spike protein to …
Source: mBioCategories: Expert Picks, Latest HeadlinesTweet-
A second study on this same topic today @mbiojournal https://t.co/HxApNRoM1k "When the persons with prior infection were subsequently vaccinated, their antibodies attained an apparent biologic ceiling of neutralizing potency against all tested variants." https://t.co/YlQ8gauc8a
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Mashup Score: 3Toll-Like Receptor (TLR) Signaling Enables Cyclic GMP-AMP Synthase (cGAS) Sensing of HIV-1 Infection in Macrophages | mBio - 2 year(s) ago
Innate immune activation is a hallmark of HIV-1 pathogenesis. Thus, it is critical to understand how HIV-1 infection elicits innate immune responses.
Source: mBioCategories: Infectious Disease, Latest HeadlinesTweet-
Drs. Masahiro Yamashita and Mohammad Adnan Siddiqui at @Columbia University show that #HIV-1 infection of macrophages leads to a robust type I interferon production only when a second signaling event is initiated by a coexisting immunostimulatory molecule. https://t.co/1keNhExJUt https://t.co/1hp3BcWQ12
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Mashup Score: 4
Salmonella enterica serovar Typhimurium (S. Typhimurium) causes a significant health burden worldwide, yet host responses to initial stages of intestinal infection remain poorly understood.
Source: mBioCategories: Infectious Disease, Latest HeadlinesTweet-
RT @UMMicroImmuno: Salmonella enterica Serovar Typhimurium SPI-1 and SPI-2 Shap https://t.co/VQ9Zm6xDVP Drs. Wobus, Young and O'Riordan @CW…
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Human nose organoids, a lab representation of cells inside the nose, allow researchers to see the first steps of infection by #SARSCoV2 and #RSV. These models provide better understanding of the diseases and may inform potential new therapies. https://t.co/NsbejYmyQp #NIH