In the battle against cancer, researchers are exploring the use of engineered bacteria as living medicines. Redenti and colleagues demonstrate that Escherichia coli Nissle 1917 (EcN) can be engineered to deliver cancer neoantigen payloads, stimulating antigen-specific CD4+ and CD8+ T cells and mediating antitumor immunity in preclinical models of colorectal cancer and melanoma.
In this Review, Chen and Kim explore the exciting journey of discovering small and long non-coding RNAs. They also explain the current understanding as to…
Nature Reviews Molecular Cell Biology – Stephen Michnick provides a brief history of protein-fragment complementation — an approach to studying protein–protein interactions in living…
Key Points. Human pDCs express ATP13A2 in their endolysosomal compartments.ATP13A2-mediated polyamine transport regulates TLR9/7 activation in pDCs.ATP13A2
Pulm Pharmacol Ther. 2024 Nov 19:102333. doi: 10.1016/j.pupt.2024.102333. Highlights Inhaled triple therapy (ITT) is still not widely used in asthmatic patients. The Interasma Scientific Network…
“A blog about allergy, asthma & immunology”
BOSTON — Patients with chronic rhinosinusitis with nasal polyps showed low biologics use and high discontinuation rates, according to a presentation at the American College…
Nature Reviews Molecular Cell Biology – In this Comment article, Monika Fuxreiter discusses possible roles of dynamic, fuzzy protein interactions and their importance in changing…
The relationship between antigen recognition and HIV-1 gene expression is unclear. Moskovjlevic et al. reveal that CD4+ T cell antigen recognition can drive HIV-1 transcription in individuals…
CRY2 interacts with the cell-division-promoting factors FL1 and FL3 to inhibit primary-root elongation in darkness, while blue light relieves this inhibition.
Sun et al. demonstrate that APOE3 Christchurch microglia protect neurons from Aβ-induced Tau pathology by regulating lipid peroxidation and phagocytosis. Targeting APOE and lipid metabolism in…
