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The (pro)renin receptor in health and disease

posted 7 hours

Mashup Score: 7

Nature Reviews Nephrology - Here, the authors discuss the multiple functions of the (pro)renin receptor in physiological processes, including blood pressure regulation, energy metabolism and autophagy, as well...

APOL1, Black Race, and Kidney Disease: Turning Attention to Structural Racism

posted 6 hours

Mashup Score: 6

American Journal of Kidney Diseases - The incidence of end-stage kidney disease (ESKD) is nearly three times higher in Black relative to White Americans.1 A significant body of biomedical literature...

Immunology of the ageing kidney

posted 1 day

Mashup Score: 6

Nature Reviews Nephrology - Immunological ageing has profound effects on the immune system and its ability to protect the host against infection, cancer and autoimmunity. In this Review,...

American Society of Nephrology - Approximately 20% of patients with lupus nephritis, the most common renal manifestation of systemic lupus erythematosus, show membranous lupus nephritis on kidney biopsy, and...

  • On kidney biopsy, the one-third of patients with membranous lupus nephritis who test positive for two proteins, exostosin 1 and 2, are less likely than EXT1/EXT2-negative patients to show biopsy findings signifying chronic disease or develop ESKD https://t.co/4y0hBwRXJN https://t.co/4y0hBwRXJN

Sex Disparity in Deceased-Donor Kidney Transplant Access by Cause of Kidney Disease

posted 4 hours

Mashup Score: 5

American Society of Nephrology - Background and objectives Women with kidney failure have lower access to kidney transplantation compared with men, but the magnitude of this disparity may not...

  • A study found that disparity in transplant access by sex is inconsistent across all causes of kidney failure. Lower deceased-donor transplantation rates in women compared to men are more notable among patients with kidney failure attributed to diabetes https://t.co/5NGj3BOdCv https://t.co/5NGj3BOdCv

American Society of Nephrology - Background and objectives Panel reactive antibody informs the likelihood of finding an HLA-compatible donor for transplant candidates, but has historically been associated with acute...

Steroid Regimen for Children with Nephrotic Syndrome Relapse

posted 8 hours

Mashup Score: 4

American Society of Nephrology - Nephrotic syndrome is the most common cause of glomerular disease in school-age and adolescent children, affecting two to five children in 100,000 each year...

  • "Nephrotic syndrome is the most common cause of glomerular disease in school-age and adolescent children, affecting two to five children in 100,000 each year." Our latest editorial piece analyzes pediatric treatments for nephrotic syndrome https://t.co/NvTuNJjls0 https://t.co/NvTuNJjls0

Alerting AKI and Avoiding Adverse Aftermaths — NephJC

posted 4 hours

Mashup Score: 3

NephJC - This week we discuss the AKi Alert trial from BMJ. Surely alerting us to AKI earlier will be helpful, right? Maybe – or maybe...

Benzodiazepines, Codispensed Opioids, and Mortality among Patients Initiating Long-Term In-Center Hemodialysis

posted 1 day

Mashup Score: 3

American Society of Nephrology - Background and objectives Mortality from benzodiazepine/opioid interactions is a growing concern in light of the opioid epidemic. Patients on hemodialysis suffer from a high...

  • 2020 Editors’ Choice Article: Benzodiazepines, Codispensed Opioids, and Mortality among Patients Initiating Long-Term In-Center Hemodialysis: Codispensing of opioids & short-acting benzodiazepines is common among dialysis patients, with ↑ mortality risk https://t.co/35eo2jIHXC https://t.co/35eo2jIHXC

Membranous Nephropathy: Core Curriculum 2021

posted 2 days

Mashup Score: 2

American Journal of Kidney Diseases - The understanding and management of membranous nephropathy, a common cause of nephrotic syndrome that is more frequently encountered in adults than in children, has...