-
Mashup Score: 51An International Study of Variation in Attitudes to Kidney... : Clinical Journal of the American Society of Nephrology - 16 hour(s) ago
world. Methods: An online questionnaire for nephrologists was designed based on the existing literature with input from patients. Anonymized data was collected on individual and institutional demographics, indications and contraindications for biopsy, and attitudes and barriers to access. A propensity-to-biopsy score was generated from responses which allowed clinicians to compare their practice with international colleagues. A higher score was associated with an increased likelihood of recommending biopsy. The questionnaire was disseminated through international nephrology societies including the National Kidney Foundation and by social media. Results: Participants responding to the questionnaire included 1181 clinicians from 83 countries, making it the largest international study in this area to date. The propensity-to-biopsy scores were significantly different between the thirteen countries with over twenty clinicians participating (P<0.001) and was highest in Mexico and lowest in t
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet
-
Mashup Score: 60Biomarker Panels for Predicting Progression of Kidney... : Clinical Journal of the American Society of Nephrology - 7 day(s) ago
atients with AKI in the Assessment, Serial Evaluation, and Subsequent Sequelae of AKI (ASSESS-AKI) Study. Using machine learning, we investigated 75 candidate predictors including biomarkers measured at three-month post-discharge follow-up to predict major adverse kidney events (MAKE) within three years, defined as a decline in eGFR ≥40%, development of end-stage kidney disease (ESKD), or death. Results: The mean age of study participants was 64 ± 13 years, 68% were men, and 79% were of White race. Two hundred and four (28%) patients developed MAKE over 3 years of follow-up. Random forest and LASSO penalized regression models using all 75 predictors yielded area under the receiver-operating characteristic curve (AUC) values of 0.80 (95% CI: 0.69-0.91) and 0.79 (95% CI: 0.68-0.90) respectively. The most consistently selected predictors were albuminuria, soluble tumor necrosis factor receptor 1 (sTNFR1), and diuretic use. A parsimonious model using the top eight predictor variables showe
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet-
AKI increases the risk for chronic kidney disease CKD. This study found that combining clinical data and biomarkers can accurately identify high-risk AKI patients, enabling personalized post-AKI care and improved outcomes. https://t.co/R5jp8MSCHr @alpikizler @asgmd1 @dmoledina… https://t.co/5sbcM1NgCc https://t.co/JVUKukk9Cf
-
-
Mashup Score: 15Perspectives on Long-Term Follow-Up among Living Kidney... : Clinical Journal of the American Society of Nephrology - 10 day(s) ago
ization or change in health. Background The long-term follow-up of living kidney donors is highly variable in Canada. Methods We surveyed perspectives on postdonation follow-up among 685 living donors in the two largest transplant programs in Canada (43% survey response rate). The anonymous survey was informed by semistructured interviews with 12 living kidney donors. The survey was developed on the basis of themes identified in the semistructured interviews, guidance from the research and clinical teams, and feedback from pilot testing with six previous donors. Results Most (73%) of the respondents received follow-up after the first donation year from a primary care provider, and 70% reported annual follow-up visits, including blood and urine tests. Most (71%) received a follow-up reminder from their transplant center, and follow-up was higher (86% versus 68%) among those receiving reminders. Donors wanted specialist involvement if new health or kidney-related events occurred. Most (7
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet
-
Mashup Score: 14Neighborhood Socioeconomic Deprivation is Associated with... : Clinical Journal of the American Society of Nephrology - 24 day(s) ago
listing transplanted January 1st, 2010, to May 31st, 2022 (N=9,178) were included from the Scientific Registry of Transplant Recipients. Recipients were stratified into three groups according to Material Community Deprivation Index score, with greater score representing higher neighborhood socioeconomic deprivation. Outcomes were modeled using multivariable logistic regression and Cox proportional hazards models. Results: Twenty-four percent (N=110) of recipients from neighborhoods of high socioeconomic deprivation identified as being of Black race, versus 12% (N=383) of recipients from neighborhoods of low socioeconomic deprivation. Neighborhoods of high socioeconomic deprivation had a much greater proportion of recipients identifying as being of Hispanic ethnicity (67%, N=311), versus neighborhoods of low socioeconomic deprivation (17%, N=562). The hazard of graft loss was 55% higher (aHR 1.55, 95% CI: 1.24, 1.94) for recipients from neighborhoods of high versus recipients from low s
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet
-
Mashup Score: 54Risk of Major Adverse Cardiovascular Events in Home... : Clinical Journal of the American Society of Nephrology - 1 month(s) ago
d continuous ambulatory peritoneal dialysis (CAPD), automated peritoneal dialysis (APD) and home hemodialysis (HD) with in-center HD patients. Methods: We included 968 patients who entered dialysis in the Helsinki-Uusimaa healthcare district in Finland from 2004 to 2017, of whom 162 were on CAPD, 229 on APD, 145 on home HD and 432 on in-center HD at day 90 from the start of dialysis. MACE was defined as acute myocardial infarction, stroke, or death due to cardiovascular disease. The cumulative incidence of the first MACE was calculated. Cox regression was used to compare risk of MACE between dialysis modalities with adjustment for potential confounding factors. Results: Of all 968 patients, 195 (20%) experienced a MACE during the entire follow-up and 62 (6%) during the first year of follow-up. The cumulative incidence of first MACE was similar in in-center HD and CAPD patients and higher than that in APD and home HD patients. After adjustment for possible confounders, the hazard ratio
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet
-
Mashup Score: 130How I Treat Rhabdomyolysis-Induced AKI? : Clinical Journal of the American Society of Nephrology - 1 month(s) ago
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet
-
Mashup Score: 42Exercise and Cognitive Function in Chronic Kidney Disease:... : Clinical Journal of the American Society of Nephrology - 1 month(s) ago
as particularly beneficial and that exercise did not substantially increase harms. Background People living with CKD are at higher risk of cognitive impairment. Exercise may improve cognitive function. This systematic review and meta-analysis of randomized controlled trials was completed to determine the efficacy and harms of exercise in improving cognitive function in people living with CKD. Methods A systematic literature review identified randomized controlled trials of people with any stage of CKD, with an intervention that exercised large-muscle groups, and with a validated outcome measure of cognitive function. First, harms were analyzed. Then a random-effects meta-analysis was completed with subsequent planned subgroup analyses to investigate heterogeneity between CKD stages and treatments; between different exercise types, durations, and intensities; and between different outcome methodologies. Finally, quality of evidence was rated. Results Nineteen trials randomized 1160 part
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet
-
Mashup Score: 57Bisphosphonate Use After Kidney Transplantation Is... : Clinical Journal of the American Society of Nephrology - 1 month(s) ago
bisphosphonates associates with lower incidence of non-vertebral fractures after kidney transplantation. Methods: We conducted a retrospective review for all Southern California Kaiser Permanente kidney transplant recipients with osteoporosis transplanted between 2000 and 2019. Baseline variables were collected. Those prescribed an oral bisphosphonate were compared to those who were not. The primary outcome was non-vertebral fracture. Chi square was used to evaluate categorical variables and Wilcoxson rank sum test for continuous variables. Propensity scores were generated to balance covariates in the bisphosphonate and non-bisphosphonate groups. Cause-specific hazard and sub distribution (Fine-Gray) methods were performed for competing risk analysis. Death censored graft survival was evaluated as a secondary outcome using standard Cox regression. Results: There were 489 patients included in the study, 203 of which were in the bisphosphonate group. The cause specific hazard model sugge
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet
-
Mashup Score: 13Neighborhood Socioeconomic Deprivation is Associated with... : Clinical Journal of the American Society of Nephrology - 1 month(s) ago
listing transplanted January 1st, 2010, to May 31st, 2022 (N=9,178) were included from the Scientific Registry of Transplant Recipients. Recipients were stratified into three groups according to Material Community Deprivation Index score, with greater score representing higher neighborhood socioeconomic deprivation. Outcomes were modeled using multivariable logistic regression and Cox proportional hazards models. Results: Twenty-four percent (N=110) of recipients from neighborhoods of high socioeconomic deprivation identified as being of Black race, versus 12% (N=383) of recipients from neighborhoods of low socioeconomic deprivation. Neighborhoods of high socioeconomic deprivation had a much greater proportion of recipients identifying as being of Hispanic ethnicity (67%, N=311), versus neighborhoods of low socioeconomic deprivation (17%, N=562). The hazard of graft loss was 55% higher (aHR 1.55, 95% CI: 1.24, 1.94) for recipients from neighborhoods of high versus recipients from low s
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet
-
Mashup Score: 138Prevalence and Outcomes of Chronic Kidney Disease... : Clinical Journal of the American Society of Nephrology - 2 month(s) ago
ransfer to HD. Methods: We analyzed a multicenter, international cohort of PD patients enrolled in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) from 2014-2022. Pruritus was assessed at entry into PDOPPS with a single-question Likert Scale capturing the extent to which patients were bothered by itch ranging from 1: Not at all, to 5: Extremely. The KDQOL-36 and the Centre for Epidemiological Studies Depression Scale assessed various PROs. Moderate to extreme pruritus was defined as a Likert scale score ≥3. The associations of pruritus with PROs were assessed using linear/logistic regression where appropriate. Death or HD transfer was assessed using multivariable Cox regression models. Results: Overall, 5535 patients from seven countries were included; 43% had moderate to extreme pruritus which was highest in Thailand (50%) and lowest in the United States (33%). The adjusted odds ratios (aOR) of moderate to extreme pruritus were higher for diabetes, low albumin, a
Source: journals.lww.comCategories: General Medicine News, NephrologyTweet-
Pruritus is common in hemodialysis patients. This study found that pruritus is highly prevalent in peritoneal dialysis and associated with poor health outcomes. https://t.co/geGp16GhT8 @BieberBrian @DWJohnsonNeph @home_dialysis @markrlambie @PD_Perls @tennankore @KRINS_1… https://t.co/5jPtIZWCMf https://t.co/4NZmxD9xJ2
-
A kidney biopsy is an essential investigation for diagnosis but is invasive and associated with complications. This study found that kidney biopsy practice is varied internationally and is subject to human and systemic factors. https://t.co/zENK1rihyc https://t.co/QGLTNI87Nz