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Mashup Score: 0
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) improve cardiac and kidney outcomes in patients with diabetes; however their efficacy in individuals with reduced estimated glomerular filtration rate (eGFR) is uncertain. This study evaluated the effects of GLP-1RAs on kidney and cardiovascular (CV) outcomes in patients with chronic kidney disease (CKD).
Source: www.ajkd.orgCategories: General Medicine News, NephrologyTweet
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Mashup Score: 27Progressive Kidney Dysfunction With Weight Loss: A Quiz - 18 hour(s) ago
A 54-year-old male patient presented with a 1-year history of fatigue, anorexia, nonproductive cough, intermittent fever, and progressive weight loss of 50kg. His medical history included a bicuspid aortic valve, for which he underwent bioprosthetic valvular replacement 9 years earlier and a subsequent replacement with a mechanical valve 5 years later after prolapse of the bioprosthetic valve. Other medical history included type 2 diabetes mellitus, coronary artery disease, and hypertension. His medications included metformin, warfarin, carvedilol, ferrous sulfate, and atorvastatin.
Source: www.ajkd.orgCategories: General Medicine News, NephrologyTweet-
#Quiz A 54-year-old male presented with fatigue, fever, and progressive weight loss. He had bilateral lower extremity edema and elevated serum creatinine. What is the diagnosis? https://t.co/UiZ696TRzn (FREE) @NivsGiri, @KUNeph https://t.co/AxQJ3aL6a8
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Mashup Score: 5Do Topiramate and Zonisamide Cause Kidney Stones? - 1 day(s) ago
Symptomatic kidney stone events confer significant population-level morbidity and mortality,1 with increasing worldwide incidence and prevalence rates over the last few decades.2 A vast majority (over 80%) of human stones contain calcium, mostly in the form of calcium oxalate; however, more than 10% of analyzed stones contain a majority of calcium phosphate (CaP).3 The fraction of CaP stones is even higher in the second and third decades of life, and more so in younger women than men.3 The reasons for these demographic trends remain unclear.
Source: www.ajkd.orgCategories: General Medicine News, NephrologyTweet-
RT @MayoClinicNeph: Do Topiramate and Zonisamide Cause Kidney Stones? https://t.co/Hr5Qg5vWoX @lieske_john @AJKDonline Editorial by Har…
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Mashup Score: 32Non-Plasmapheresis Approaches for Managing Severe Renal Thrombotic Microangiopathy: A Report of 7 Cases - 1 day(s) ago
C5-blockers are the established treatment for complement-mediated hemolytic uremic syndrome (CM-HUS). However, CM-HUS, lacking a definitive test, prompts plasma exchanges as a common first-line therapy, pending further assessments, despite complications and limited evidence in this indication. Recent experts’ opinion endorses C5-blockers as the initial treatment for severe renal thrombotic microangiopathy (TMA). This retrospective, single center study reports a series of seven patients treated with a plasmapheresis-free approach.
Source: www.ajkd.orgCategories: General Medicine News, NephrologyTweet-
Non-Plasmapheresis Approaches for Managing Severe Renal Thrombotic Microangiopathy: A Report of 7 Cases https://t.co/ya5eRasMUC #OpenAccess @MaanaouiMehdi https://t.co/wQhY3dO3nv
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Mashup Score: 3
Social determinants of health and limited access to medical care contribute to underdiagnosis and late presentation of chronic kidney disease (CKD). Rural areas face unique challenges in providing optimal care for patients with CKD due to poverty, limited healthcare access, and geographical barriers. This review will address the challenges of caring for rural patients with CKD and discuss potential strategies to increase healthcare equity. Furthermore, we will examine rural disparities in patients with CKD, patients with kidney failure on in-center or home dialysis, and patients with kidney transplants, highlighting the need for targeted interventions to address these disparities.
Source: www.ajkd.orgCategories: General Medicine News, NephrologyTweet-
Perspective by @skoppula22, Krishna Patel, and @markunruh_01: The Delivery of Kidney Care in Rural or Sparsely Populated Settings https://t.co/gtDuUEKTnJ https://t.co/BuLsgurOkx
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Mashup Score: 36Biomarkers of Rejection in Kidney Transplantation - 2 day(s) ago
Alloimmune injury is a major cause of long-term kidney allograft failure whether due to functionally stable (subclinical) or overt clinical rejection. These episodes may be mediated by immune cells (cellular rejection) or alloantibody (antibody-mediated rejection). Early recognition of immune injury is needed for timely appropriate intervention to maintain graft functional viability. However, the conventional measure of kidney function (ie, serum creatinine) is insufficient for immune monitoring due to limited sensitivity and specificity for rejection.
Source: www.ajkd.orgCategories: General Medicine News, NephrologyTweet-
Review by @ScottWestphal20 and @mannonmom: Biomarkers of Rejection in Kidney Transplantation https://t.co/RNFdl5FeCu (FREE) @unmckidney https://t.co/7fJipYaDCk
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Mashup Score: 41
I distinctly remember sitting in class as a second-year medical student learning about end-stage kidney disease. This topic was not new to me—unfortunately, weeks earlier, my 89-year-old grandmother had received a diagnosis of this devastating illness.
Source: www.ajkd.orgCategories: General Medicine News, NephrologyTweet-
In A Few Words essay by @christina5567: Considering Dialysis in Octogenarians and Nonagenarians Living With Kidney Failure https://t.co/3asb4JD8ZI (FREE) @StanfordMed https://t.co/qh9MRMoqln
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Mashup Score: 2Urea to Treat Hyponatremia Due to Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Systematic Review and Meta-Analysis - 3 day(s) ago
The use of urea to treat hyponatremia related to the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) has not been universally adopted due to questions about effectiveness, safety, and tolerability. This systematic review and meta-analysis of observational studies aimed to address these questions.
Source: www.ajkd.orgCategories: General Medicine News, NephrologyTweet-
Urea to Treat Hyponatremia Due to Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Systematic Review and Meta-Analysis - American Journal of Kidney Diseases https://t.co/0x8MOY6MqD https://t.co/lHTYhkfsj7
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Mashup Score: 6Do Topiramate and Zonisamide Cause Kidney Stones? - 3 day(s) ago
Symptomatic kidney stone events confer significant population-level morbidity and mortality,1 with increasing worldwide incidence and prevalence rates over the last few decades.2 A vast majority (over 80%) of human stones contain calcium, mostly in the form of calcium oxalate; however, more than 10% of analyzed stones contain a majority of calcium phosphate (CaP).3 The fraction of CaP stones is even higher in the second and third decades of life, and more so in younger women than men.3 The reasons for these demographic trends remain unclear.
Source: www.ajkd.orgCategories: General Medicine News, NephrologyTweet-
@MKOerline @StoneCrushed @ravineja @dorkstweet @UMichKidney @UMichUrology Editorial by Harshil A. Fichadiya and @lieske_john: Do Topiramate and Zonisamide Cause Kidney Stones? https://t.co/rIGfVQZTj2 (FREE) @MayoClinicNeph https://t.co/nzNAQLU5v2
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Mashup Score: 11The New Cardiovascular-Kidney-Metabolic (CKM) Syndrome: An Opportunity for CKD Detection and Treatment in Primary Care - 4 day(s) ago
In October of 2023, the American Heart Association (AHA) published a scientific statement and advisory that defined a novel entity, the Cardiovascular-Kidney-Metabolic (CKM) Syndrome.1,2 The overall framework proposes that a substantial proportion of cardiovascular disease (CVD) burden is attributable to a syndrome that extends in stages from: Stage 1) obesity, Stage 2) metabolic/kidney risk factors for CVD (diabetes mellitus, chronic kidney disease (CKD), hypertension, and dyslipidemia), Stage 3) subclinical CVD, and finally Stage 4) clinical CVD. The report that describes the CKM paradigm documents the scientific justification for a syndrome, highlights the overlap in risk factors among individuals with obesity, diabetes, CKD, and CVD, and aligns the evidence and guideline statements that address screening, prevention, and management of these conditions. Overall, the CKM Syndrome is an aspirational framework that pulls from a wide body of literature and disease-specific guidelines wi
Source: www.ajkd.orgCategories: General Medicine News, NephrologyTweet-
Editorial by Sara-Megumi Rumrill and @shlipak_khrc: The New Cardiovascular-Kidney-Metabolic (CKM) Syndrome: An Opportunity for CKD Detection and Treatment in Primary Care https://t.co/v2uuqldu7E (FREE) @UCSFNephrology https://t.co/25OkFVLxOv
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Kidney and Cardiovascular Outcomes Among Patients With CKD Receiving GLP-1 Receptor Agonists: A Systematic Review and Meta-Analysis of Randomized Trials https://t.co/dQpXdFvXMW #OpenAccess @jefflaintuh #VisualAbstract https://t.co/iSPb5QQvAD