Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis
How dendritic cells (DCs) regulate human tissue immunity remains unclear. MacDonald, Elmesmari, Somma, Frew, et al. investigate the role of synovial tissue (ST) myeloid DCs in health and active and remission stages of rheumatoid arthritis. Using a combination of scRNA-seq, spatial transcriptomics, and DC:T cell co-cultures, the authors identify functional features of ST-DCs that reveal their roles in immune tolerance and disease.
