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Mashup Score: 2Associate Professor in Developmental Psychology at Trinity College Dublin, The University of Dublin - 15 hour(s) ago
Looking for a new job opportunity in academia? Check out this job opening for a Associate Professor in Developmental Psychology on jobs.ac.uk!
Source: www.jobs.ac.ukCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 6Saturday Morning Breakfast Cereal - Fossils - 16 hour(s) ago
Saturday Morning Breakfast Cereal – Fossils
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Mashup Score: 2Functional dissection of complex and molecular trait variants at single nucleotide resolution - 2 day(s) ago
Identifying the causal variants and mechanisms that drive complex traits and diseases remains a core problem in human genetics. The majority of these variants have individually weak effects and lie in non-coding gene-regulatory elements where we lack a complete understanding of how single nucleotide alterations modulate transcriptional processes to affect human phenotypes. To address this, we measured the activity of 221,412 trait-associated variants that had been statistically fine-mapped using a Massively Parallel Reporter Assay (MPRA) in 5 diverse cell-types. We show that MPRA is able to discriminate between likely causal variants and controls, identifying 12,025 regulatory variants with high precision. Although the effects of these variants largely agree with orthogonal measures of function, only 69% can plausibly be explained by the disruption of a known transcription factor (TF) binding motif. We dissect the mechanisms of 136 variants using saturation mutagenesis and assign impac
Source: www.biorxiv.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 52
Kevin Mitchell is an associate professor of Genetics and Neuroscience at Trinity College Dublin. His research is aimed at understanding the genetic program s…
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Mashup Score: 1
The efficient coding approach proposes that neural systems represent as much sensory information as biological constraints allow. It aims at formalizing encoding as a constrained optimal process. A different approach, that aims at formalizing decoding, proposes that neural systems instantiate a generative model of the sensory world. Here, we put forth a normative framework that characterizes neural systems as jointly optimizing encoding and decoding. It takes the form of a variational autoencoder: sensory stimuli are encoded in the noisy activity of neurons to be interpreted by a flexible decoder; encoding must allow for an accurate stimulus reconstruction from neural activity. Jointly, neural activity is required to represent the statistics of latent features which are mapped by the decoder into distributions over sensory stimuli; decoding correspondingly optimizes the accuracy of the generative model. This framework yields in a family of encoding-decoding models, which result in equa
Source: www.biorxiv.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 2To P or not to P? | BPS - 4 day(s) ago
Marcus Munafò, our new Associate Editor for Research, on credibility in how psychologists report results.
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Mashup Score: 140Tesla Lays Off Entire Team Behind Brakes - 4 day(s) ago
AUSTIN, TX—In the latest round of layoffs for the company’s struggling automotive division, electric vehicle manufacturer Tesla fired the entire team behind brakes, sources confirmed Wednesday. “As we continue to rightsize the Tesla workforce, we have come to the decision that stopping the car is no longer a critical…
Source: www.theonion.comCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 7
Nature Neuroscience – The layout of cortical systems varies across people, which is assumed to be largely due to border shifts between nearby systems. Dworetsky et al. reveal a qualitatively…
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Mashup Score: 14
The question of whether the early visual cortex (EVC) is involved in visual mental imagery remains a topic of debate. In this paper, I propose that the inconsistency in findings can be explained by the unique challenges associated with investigating EVC activity during imagery. During perception, the EVC processes low-level features, which means that activity is highly sensitive to variation in visual details. If the EVC has the same role during visual mental imagery, any change in the visual details of the mental image would lead to corresponding changes in EVC activity. Within this context, the question should not be whether the EVC is ‘active’ during imagery but how its activity relates to specific imagery properties. Studies using methods that are sensitive to variation in low-level features reveal that imagery can recruit the EVC in similar ways as perception. However, not all mental images contain a high level of visual details. Therefore, I end by considering a more nuanced view
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Mashup Score: 21
Fang et al. discovered that male and female mice display different empathic behaviors in response to others’ pain. Specifically, males engage in self-grooming, whereas females demonstrate social approaching. Processing information about others’ pain involves distinct neural circuits for each sex. Importantly, these circuits inherently differ in gene expression patterns.
Source: www.cell.comCategories: General Medicine News, Future of MedicineTweet
RT @PsychologyTCD: Broken link. Please use this one https://t.co/gcZHy4a1UY