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Mashup Score: 24Salvage Reirradiation with Proton Beam Therapy for Locoregionally Recurrent Non-Small Cell Lung Cancer - 17 hour(s) ago
Background/Objectives: This retrospective study evaluates outcomes of 66 patients who underwent reirradiation (re-RT) with proton beam therapy (PBT) for recurrent non-small cell lung cancer. Methods: Toxicity was scored via the CTCAE v5.0, and outcomes estimated using the Kaplan–Meier method, with associations evaluated via Cox proportional hazards and logistic regression analyses. Results: Patients were treated to a median re-RT prescription of 66 Gy/33 fxs (BED10 = 79 Gy; IQR: 71–84 Gy) at an interval of 1.4 years from prior RT. Half (50%) received concurrent chemotherapy. At 14 months follow-up, the median OS and PFS were 5 months (95%CI: 13–17) and 12.5 months (95%CI: 10–15), respectively. On multivariable analysis, a higher RT dose (BED10 > 70 Gy) [HR0.37; 95%CI: 0.20–0.68, p = 0.001] and concurrent chemotherapy (HR0.48; 95%CI: 0.28–0.81, p = 0.007) were associated with improved PFS, while treatment site overlap was adversely associated (HR1.78; 95%CI: 1.05–3.02, p = 0.031). The m
Source: www.mdpi.comCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 9
One of the most common diseases afflicting humans is knee osteoarthritis (KOA). KOA occurs when the knee joint cartilage breaks down, and knee bones start rubbing together. The diagnosis of KOA is a lengthy process, and missed diagnosis can have serious consequences. Therefore, the diagnosis of KOA at an initial stage is crucial which prevents the patients from Severe complications. KOA identification using deep learning (DL) algorithms has gained popularity during the past few years. By applying knee X-ray images and the Kellgren–Lawrence (KL) grading system, the objective of this study was to develop a DL model for detecting KOA. This study proposes a novel model based on CNN called knee osteoarthritis classification network (KOC_Net). The KOC_Net model contains 05 convolutional blocks, and each convolutional block has three components such as Convlotuioanl2D, ReLU, and MaxPooling 2D. The KOC_Net model is evaluated on two publicly available benchmark datasets which consist of X-ray i
Source: www.mdpi.comCategories: General Medicine News, General HCPsTweet-
Impact of the Synthetic Minority Over-Sampling Technique with Deep Learning Models for Classification of Knee Osteoarthritis Using Kellgren–Lawrence X-Ray Grade https://t.co/da1ZzYAfDF
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Mashup Score: 95Molecular and Cellular Modelling of Salivary Gland Tumors Open New Landscapes in Diagnosis and Treatment - 6 day(s) ago
Salivary gland tumors are neoplasms affecting the major and minor salivary glands of the oral cavity. Their complex pathological appearance and overlapping morphological features between subtypes, pose major challenges in the identification, classification, and staging of the tumor. Recently developed techniques of three-dimensional culture and organotypic modelling provide useful platforms for the clinical and biological characterization of these malignancies. Additionally, new advances in genetic and molecular screenings allow precise diagnosis and monitoring of tumor progression. Finally, novel therapeutic tools with increased efficiency and accuracy are emerging. In this review, we summarize the most common salivary gland neoplasms and provide an overview of the state-of-the-art tools to model, diagnose, and treat salivary gland tumors.
Source: www.mdpi.comCategories: General Medicine News, Hem/OncsTweet-
RT @thejourneymate: Schematic Representation of Hallmarks in Malignant Salivary Gland Tumors 🔬 https://t.co/di6JjdzsDI https://t.co/eYwVB23…
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Mashup Score: 74Audiovestibular Dysfunction Related to Anti-Phospholipid Syndrome: A Systematic Review - 6 day(s) ago
Background: Anti-phospholipid syndrome (APS) has emerged as a significant issue in autoimmune diseases over recent decades. Its hallmark feature is thromboembolic events, potentially affecting any vascularized area including the microcirculation of the inner ear. Since the first case report of APS-related audiovestibular dysfunction described in 1993, numerous reports have explored the association between APS-related antibodies and audiovestibular dysfunction. These studies indicate a higher prevalence of APS-related antibodies in patients with sensorineural hearing loss compared to healthy controls. Unlike other idiopathic hearing loss disorders, audiovestibular dysfunction associated with APS may respond to appropriate treatments, highlighting the importance of timely recognition by clinicians to potentially achieve favorable outcomes. Therefore, this systematic review aims to consolidate current evidence on the characteristics, pathophysiology, assessment, and management of audioves
Source: www.mdpi.comCategories: General Medicine News, General HCPsTweet-
Systematic review suggests (although not provn) that audiovestibular dysfunction may be from APS. Anti-phospholipid & HSP-70 Abs found 25-33% w/idiopathic sudden sensorineural hearing loss,. ACL Abs seen in up to 27% w/ sensorineural hearing loss https://t.co/WcmeCP0ryq https://t.co/DiYX57R0uG
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Mashup Score: 94Cytomegalovirus Infection After Solid Organ Transplantation: How I Use Cell-Mediated Immune Assays for Management - 7 day(s) ago
Introduction: The pathogenesis and outcome of cytomegalovirus (CMV) infection after solid organ transplantation (SOT) reflects the interplay between viral replication and CMV-specific immunity. Despite advances in its diagnosis and treatment, CMV continues to cause significant morbidity after SOT. Since CMV is an opportunistic pathogen that occurs as a result of impaired pathogen-specific immunity, laboratory assays that measure CMV-specific immune responses may be useful in assisting clinicians in its management. Methods and Results: The author summarizes the evolving and emerging data on the clinical utility of assays that quantify cell-mediated immune responses to CMV in SOT recipients. The majority of publications are observational studies that demonstrate that a lack or deficiency in CMV-specific cell-mediated immunity is correlated with a heightened risk of primary, reactivation, or recurrent CMV after transplantation. A few prospective interventional studies have utilized CMV-sp
Source: www.mdpi.comCategories: General Medicine News, Infectious DiseaseTweet-
Cytomegalovirus Infection After Solid Organ Transplantation: How I Use Cell-Mediated Immune Assays for Management https://t.co/oQwB4YKdAN #mdpiviruses via @VirusesMDPI
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Mashup Score: 3Effect of Glucagon-like Peptide-1 Receptor Agonism on Aortic Valve Stenosis Risk: A Mendelian Randomization Analysis - 7 day(s) ago
Background: Aortic valve repair is currently the only effective treatment for calcific aortic valve stenosis (CAVS), as no pharmacological therapies exist to prevent or slow its progression. Recent promising results showed that glucagon-like peptide-1 (GLP-1) attenuates the calcification of aortic valve interstitial cells. Therefore, we conducted a two-sample Mendelian randomization analysis to investigate the effect of GLP-1 receptor agonism (GLP-1Ra) on the risk of CAVS. Methods: The inverse variance weighted (IVW) method was used to obtain the primary causal inference, and several sensitivity analyses, including MR-Egger, were performed to assess the robustness of the results. Results: Based on the IVW estimates, the GLP-1Ra showed a neutral effect on the risk of CAVS (odds ratio [OR] per 1 mmol/mol decrease in glycated hemoglobin = 0.87, 95% CI = [0.69, 1.11], p = 0.259; I2 = 4.5%, Cohran’s Q = 2.09, heterogeneity p = 0.35; F statistic = 16.8). A non-significant effect was also der
Source: www.mdpi.comCategories: General Medicine News, CardiologistsTweet-
Effect of Glucagon-like Peptide-1 Receptor Agonism on Aortic Valve Stenosis Risk: A Mendelian Randomization Analysis, by Karakasis et al https://t.co/QKpTq9zje9 https://t.co/yzqkLH1851
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Mashup Score: 5Finerenone: A Third-Generation MRA and Its Impact on Cardiovascular Health—Insights from Randomized Controlled Trials - 8 day(s) ago
Introduction: Finerenone, a third-generation non-steroidal mineralocorticoid receptor antagonist (MRA), offers a targeted approach to managing cardiovascular outcomes, particularly in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D). Unlike traditional MRAs such as spironolactone and eplerenone, which can cause off-target hormonal side effects and hyperkalemia, Finerenone selectively binds to mineralocorticoid receptors, reducing these risks. Recent randomized controlled trials have demonstrated Finerenone’s potential to improve cardiovascular outcomes, making it a promising alternative in the management of heart failure and other cardiovascular conditions associated with CKD and T2D. Methods: We conducted a scoping review using PRISMA guidelines. A search for “Finerenone” in the PubMed, Embase, and Cochrane Library databases included randomized controlled trials (RCTs), post hoc analyses, and relevant meta-analyses on cardiovascular outcomes. Data were synthesized
Source: www.mdpi.comCategories: General Medicine News, CardiologistsTweet-
https://t.co/CfxqtyVG4R
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Mashup Score: 24
Purpose: We describe the impact of screening on outcomes of patients diagnosed with hepatocellular carcinoma (HCC) in an urban safety-net healthcare system compared to a non-screened cohort diagnosed with HCC. Methods: Patients diagnosed with HCC at John Peter Smith Health Network were identified by querying the hospital tumor registry and allocated to the screened cohort if they had undergone any liver imaging within one year prior to HCC diagnosis, while the remainder were allocated to the non-screened cohort. Kaplan–Meier methods and log-rank tests were used to compare 3-year survival curves from an index date of HCC diagnosis. Cox proportional hazard models were used to calculate unadjusted and adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). The Duffy adjustment was used to address lead-time bias. Results: A total of 158 patients were included (n = 53 screened, n = 105 non-screened). The median overall survival (OS) for the screened cohort was 19.0 months (95% CI:
Source: www.mdpi.comCategories: General Medicine News, Hem/OncsTweet-
Proud to share my first senior author research paper “Impact of Screening on Mortality for Patients Diagnosed with Hepatocellular Carcinoma in a Safety-Net Healthcare System: An Opportunity for Addressing Disparities” https://t.co/xfw7YlTLm3
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Mashup Score: 1People with Parkinson’s Disease Are Able to Couple Eye Movements and Postural Sway to Improve Stability - 8 day(s) ago
Considering that people with Parkinson’s disease (PD) experience challenges in the control of both balance and eye movements, this study investigated the effects of saccadic eye movements on body sway in people with PD in two bases of support positions (side-by-side and tandem stances). Ten people with PD and 11 healthy individuals performed (a) fixation; (b) horizontal saccadic eye movements to the right and left; and (c) vertical saccadic eye movements up and down. The protocol for each postural task consisted of one block of six trials, making a total of 12 trials. Body sway and gaze parameters were measured during the trials. In both people with PD and healthy individuals, anterior–posterior body sway was significantly reduced in horizontal saccadic eye movements in contrast to fixation, regardless of the body position (side-by-side and tandem stances). Furthermore, vertical saccadic eye movements increased the area of sway in contrast to horizontal ones (and not to fixation) in pe
Source: www.mdpi.comCategories: General Medicine News, OphthalmologyTweet-
Scientists at @PesquisaFapesp (Brazil) and @Unesp_Oficial have found that rapid side-to-side eye movements may help stabilize posture and maintain balance, and avoid falls for people living with #Parkinsons: https://t.co/1Ao4kavsm7 #EyeHealthcare #EyeHealth #VisionHealth https://t.co/cmjhhzgrCJ
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Mashup Score: 14Egg Consumption and 4-Year Change in Cognitive Function in Older Men and Women: The Rancho Bernardo Study - 9 day(s) ago
The effect of dietary cholesterol on cognitive function is debatable. While eggs contain high levels of dietary cholesterol, they provide nutrients beneficial for cognitive function. This study examined the effects of egg consumption on change in cognitive function among 890 ambulatory adults (N = 357 men; N = 533 women) aged ≥55 years from the Rancho Bernardo Study who attended clinic visits in 1988–1991 and 1992–1996. Egg intake was obtained in 1988–1991 with a food frequency questionnaire. The Mini-Mental Status Exam (MMSE), Trails B, and category fluency were administered at both visits to assess cognitive performance. Sex-specific multiple regression analyses tested associations of egg intake with changes in cognitive function after adjustment for confounders. The mean time between visits was 4.1 ± 0.5 years; average ages were 70.1 ± 8.4 in men and 71.5 ± 8.8 in women (p = 0.0163). More men consumed eggs at higher levels than women; while 14% of men and 16.5% of women reported nev
Source: www.mdpi.comCategories: General Medicine News, General HCPsTweet-
Egg Consumption and 4-Year Change in Cognitive Function in Older Men and Women: The Rancho Bernardo Study https://t.co/XICCh9l56I
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Great collaboration with former colleagues, led by Matt Ning on @MDAndersonNews thoracic proton re-irradiation outcomes: pt selection, higher BED, concurrent chemotherapy, reduced prior RT dose overlap correlated with improved survival and safety. ⬇️ https://t.co/QM9nj4f6yj https://t.co/E8RUPHktAk