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Mashup Score: 3Heterogeneity in allospecific T cell function in transplant-tolerant hosts determines susceptibility to rejection following infection - 14 day(s) ago
Even when successfully induced, immunological tolerance to solid organs remains vulnerable to inflammatory insults, which can trigger rejection. In a mouse model of cardiac allograft tolerance in which infection with Listeria monocytogenes (Lm) precipitates …
Source: www.ncbi.nlm.nih.govCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 0
BACKGROUND: Anthracycline-induced cardiotoxicity has a variable incidence, and the development of left ventricular dysfunction is preceded by elevations in cardiac troponin concentrations. Beta-adren
Source: www.ahajournals.orgCategories: Cardiologists, Latest HeadlinesTweet-
🤔 Great work by @ninianlang & colleagues - once again calling into question the role of troponin monitoring & “cardioprotective cardiac meds” in #anthracycline Rx. The almost unbelievable 🇮🇹 data from 2000s remains a BIG outlier... #CardioOnc https://t.co/70iemfjk6X
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Mashup Score: 1Development and validation of a rapid visual technique for left ventricular hypertrophy detection from the electrocardiogram - 8 month(s) ago
IntroductionLeft ventricular hypertrophy (LVH) detection techniques on by electrocardiogram (ECG) are cumbersome to remember with modest performance. This study validated a rapid technique for LVH detection and measured its performance against other techniques.MethodsThis was a retrospective cohort study of patients at Stanford Health Care who received ECGs and resting transthoracic echocardiograms (TTE) from 2006 through 2018. The novel technique, Witteles-Somani (WS), assesses for S- and R-wave overlap on adjacent precordial leads. The WS, Sokolow-Lyon, Cornell, and Peguero-Lo Presti techniques were algorithmically implemented on ECGs. Classification metrics, receiver-operator curves, and Pearson correlations measured performance. Age- and sex-adjusted Cox proportional hazard models evaluated associations between incident cardiovascular outcomes and each technique.ResultsA total of 53,333 ECG-TTE pairs from 18,873 patients were identified. Of all ECG-TTE pairs, 21,638 (40.6%) had TTE
Source: www.frontiersin.orgCategories: Cardiologists, Latest HeadlinesTweet-
(2/2) Sulaiman took a joke I routinely made during @StanfordDeptMed #CCU rounds about the “Witteles criteria” for detecting LVH and actually rigorously tested and proved it. INCREDIBLE! For those interested, just published here: https://t.co/JeyjzUvgI5
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Mashup Score: 2The Association of Sodium-Glucose Cotransporter 2 Inhibitors With Cardiovascular Outcomes in Anthracycline-Treated Patients With Cancer: - 9 month(s) ago
Abstract Background Sodium glucose cotransporter-2 inhibitors (SGLT2is) are hypothesized to reduce the risk of anthracycline-associated cardiotoxicity. Objectives This study sought to determine the…
Source: www.jacc.orgCategories: Cardiologists, Latest HeadlinesTweet-
Really nice thought-provoking work by @dineshpmcc1 & colleagues in @JACCJournals:#CardioOnc examining #SGLT2 inhibitors & cardioprotection in #anthracycline treated patients. 🤔Good rationale for randomized trials. Congrats! https://t.co/T40J1W9YdU https://t.co/5yNtd0iT2S
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Mashup Score: 0
BACKGROUND: AL amyloidosis is a rare, progressive, and typically fatal disease caused by both soluble and insoluble (amyloid) forms of misfolded immunoglobulin
Source: American Society of HematologyCategories: Cardiologists, Latest HeadlinesTweet-
(3/9) Prior anti-amyloid studies have shown promise in early trials but have failed in later stages, most recently with NEOD001 targeted at AL amyloidosis. https://t.co/z8TfIbFKsN
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Mashup Score: 5
This qualitative study evaluates user-generated, publicly available posts and comments about statin-related topics: ketogenic diets, diabetes, and supplements; statin adverse effects; statin hesitancy; clinical trial appraisals; pharmaceutical industry bias; and red yeast rice.
Source: jamanetwork.comCategories: Cardiologists, Latest HeadlinesTweet-
Incredible work by super⭐️ @StanfordMedRes PGY-2 #SulaimanSomani on this piece in @JAMANetworkOpen on #AI and #statins. Congratulations!!! @FaRodriguezMD @AshishSarraju @HeartBobH @StanfordDeptMed @StanfordChiefs @JAMANetwork https://t.co/YVXvNy4GLC
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Mashup Score: 12Atorvastatin Cut Anthracycline Cardiac Dysfunction - 1 year(s) ago
A daily 40-mg dose of atorvastatin for 12 months significantly cut incident cardiac dysfunction in patients with lymphoma receiving anthracycline treatment.
Source: MedscapeCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @Ron_Witteles: Nice article from @medscape covering the STOP-CA trial from #ACC23. https://t.co/5x8bkSbgbQ @TomasNeilan @AnaBaracCardio…
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Nice article from @medscape covering the STOP-CA trial from #ACC23. https://t.co/5x8bkSbgbQ @TomasNeilan @AnaBaracCardio @gmelendezMD @HanZhuMD @Paul_P_Cheng @JuneWRhee @JJheart_doc @SWaliany @ninianlang @CardioOncology @Dr_Mike_Fradley @SeanM_Wu #CardioOnc
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Mashup Score: 4Global Cardio-Oncology Viewpoints ‘Contextualize’ ESC Guidelines - 1 year(s) ago
The concerns range from low levels of evidence for some recommendations to issues of implementation and overreach.
Source: TCTMD.comCategories: Cardiologists, Latest HeadlinesTweet-
Nice article in @TCTMD on the @escardio #CardioOnc guidelines, highlighting the recent perspectives in @JACCJournals #JACC:CardioOnc. The guidelines are a true triumph, but with some very important words of caution… ⚠️⚠️⚠️ https://t.co/u4oLNW2OLY
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Mashup Score: 6
IntroductionIt is difficult to assign a precise date to the birth of the field of cardio-oncology. Although cardiac effects of anthracyclines have been known for decades, the field as we now know it truly emerged in the early to mid-2000s, largely in response to recognized cardiac toxicities from trastuzumab and vascular endothelial growth factor (VEGF) inhibitors. Since that time, the field has…
Source: JACC: CardioOncologyCategories: Cardiologists, Latest HeadlinesTweet-
Proud of the series of editorials on the @escardio #CardioOncology guidelines just published in @JACCJournals JACC:CardioOncology. Link attached for ours. The guidelines are a TRUE triumph - but with a major caution⚠️around promoting overscreening. https://t.co/1rawReIb41
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Mashup Score: 1JACC: CardioOncology: Vol 4, No 4 - 1 year(s) ago
MINI-FOCUS ISSUE: AMYLOIDOSIS AL Amyloidosis for Cardiologists: Awareness, Diagnosis, and Future Prospects: JACC: CardioOncology State-of-the-Art Review State-of-the-Art Review …
Source: www.jacc.orgCategories: Cardiologists, Latest HeadlinesTweet-
Proud to present the November 2022 mini-focus issue on #amyloidosis in @JACCJournals #JACCCardioOncology. Follows up last year’s fantastic Amyloidosis special issue. Check it out! 🥳 https://t.co/kA3hHQMe1s
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RT @StanfordMedRes: Check out PGY-1 @C_M_McIntosh's latest publication! #ResidentResearch https://t.co/l4iM0hWcfk Additional shoutout t…