-
Mashup Score: 1Genomic and immune determinants of resistance to anti-CD38 monoclonal antibody-based therapy in relapsed refractory multiple myeloma. - 5 month(s) ago
Anti-CD38 antibody therapies have transformed multiple myeloma (MM) treatment. However, a large fraction of patients inevitably relapses. To understand this, we investigated 32 relapsed MM patients treated with daratumumab, lenalidomide, and dexamethasone (Dara-Rd; [NCT03848676][1]). Whole genome sequencing (WGS) before and after treatment pinpointed genomic drivers associated with early progression, including RPL5 loss and APOBEC mutagenesis. Flow cytometry on 202 blood samples, collected every three months until progression for 31 patients, revealed distinct immune changes significantly impacting clinical outcomes. Progressing patients exhibited significant depletion of CD38+ NK cells, persistence of T cell exhaustion, and reduced depletion of T-reg cells over time. These findings underscore the influence of immune composition and daratumumab-induced immune changes in promoting MM resistance. Integrating genomics and flow cytometry unveiled associations between adverse genomic featur
Source: www.medrxiv.orgCategories: General Medicine News, Hem/OncsTweet
-
Mashup Score: 1[Total Gastrectomy for Gastric Invasion of Multiple Myeloma-A Case Report] - PubMed - 5 month(s) ago
A 65-year-old woman was referred to our hospital for lumbago. The patient was diagnosed with multiple myeloma in 2020. She underwent chemotherapy and radiation therapy, and the disease progression stabilized. In 2022, the patient presented with severe anemia(Hb 4.9 mg/dL), and upper gastrointestinal …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, Hem/OncsTweet-
RT @MyelomaCases: Total Gastrectomy for Gastric Invasion of Multiple Myeloma-A Case Report https://t.co/WqjWA54bCE
-
-
Mashup Score: 1Iris Plasmacytoma in Multiple Myeloma - 6 month(s) ago
A 74-year-old woman, under complete remission for a multiple myeloma, presented with painless blurred vision in her left eye. Visual acuity was 20/40 with intraocular pressure of 27 mmHg. Examination revealed a hemorrhagic whitish iris mass (A, B). Iris biopsy demonstrated a monoclonal plasma cell infiltration, with positive immunoreactivity for kappa light chains (C), consistent with the diagnosis of iris plasmacytoma. In the absence of systemic recurrence, a local 40 Gy radiotherapy treatment was delivered to the eye, allowing the total regression of the lesion.
Source: www.aaojournal.orgCategories: General Medicine News, Hem/OncsTweet-
RT @ophthopedia: Ophthopedia Update: Iris Plasmacytoma in Multiple Myeloma https://t.co/46SvYxNkUL #Ophthalmology #ophthotwitter #eyecare h…
-
-
Mashup Score: 50
The human microbiome has become an area of intense research due to its potential impact on human health. However, the analysis and interpretation of this data have proven to be challenging due to its complexity and high dimensionality. Machine learning (ML) algorithms can process vast amounts of data to uncover informative patterns and relationships within the data, even with limited prior knowledge. Therefore, there has been a rapid growth in the development of software specifically designed for the analysis and interpretation of microbiome data using ML techniques. These software incorporate a wide range of ML algorithms for clustering, classification, regression, or feature selection, to identify microbial patterns and relationships within the data and generate predictive models. This rapid development with a constant need for new developments and integration of new features require efforts into compile, catalog and classify these tools to create infrastructures and services with ea
Source: www.frontiersin.orgCategories: General Medicine News, Hem/OncsTweet-
RT @jcamthrash: A toolbox of machine learning software to support microbiome analysis https://t.co/806sw5ve6e
-
-
Mashup Score: 38'She wanted to help people:' Calgary breast cancer research advocate, 39, dies after disease metastasized - 8 month(s) ago
A young mother who openly shared her experience with terminal breast cancer on social media and called for government changes in research and screening has died.
Source: calgary.ctvnews.caCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @LibbyMbc: https://t.co/Fm6J4Njtqv
-
-
Mashup Score: 3PathElective - 10 month(s) ago
PathElective is an interactive pathology website for medical students and residents seeking a virtual pathology elective experience or introductory pathology information for junior pathology residents. Featuring introductory lectures in all fields of anatomic and clinical pathology, histology, labor
Source: www.pathelective.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @JMGardnerMD: I ❤️ https://t.co/UwN9Hr3Ufr! If you want to get some awesome #pathology education for free, this is the site for you. Sho…
-
-
Mashup Score: 1Bone Marrow Browser - 10 month(s) ago
Single cell transcriptomics of bone marrow cells – Multiple Myeloma and controls
Source: www.bmbrowser.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @Sabrin_Tahri: @TCupedo 8/ And, as all work from the Cupedo lab, datasets are available online: to explore: https://t.co/4NQG8yJuDA to…
-
-
Mashup Score: 2
The role of the microbiota in tumorigenesis has garnered considerable attention over the past two decades. In this Review, El Tekle and Garrett explore the current and evolving understanding of microbiota in cancers of various internal organs, as well as highlighting opportunities for targeting bacteria for cancer prevention, diagnostics and treatment.
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @NCIEytanRuppin: Bacteria in cancer initiation, promotion and progression @NatureRevCancer https://t.co/2PxdW7De8P
-
-
Mashup Score: 1Colossal Cave Adventure - Wikipedia - 11 month(s) ago
“Twisty little maze of passages” redirects here. For the book Twisty Little Passages: An Approach to Interactive Fiction, see Nick Montfort. Colossal Cave Adventure (also known as Adventure or ADVENT) is a text-based adventure game, released in 1976 by developer Will Crowther for the PDP-10 mainframe computer. It was expanded upon in 1977 by Don Woods. In the game, the player explores a cave…
Source: en.m.wikipedia.orgCategories: Hem/Oncs, Latest HeadlinesTweet-
@barttels2 I think I'm just talking to myself. It's okay! 😄 https://t.co/J4H5fEd1WL
-
-
Mashup Score: 1RNA Nanoparticle Therapy Stops the Spread of Incurable Bone Marrow Cancer - Penn Engineering Blog - 11 month(s) ago
Multiple myeloma is an incurable bone marrow cancer that kills over 100,000 people every year. Known for its quick and deadly spread, this disease is … Read More ›
Source: Penn Engineering BlogCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @AmericanElement: Nanoparticles deliver small interfering RNA to slow multiple myeloma https://t.co/g9ytCKwJFf
-
RT @FrancescoMaura4: https://t.co/waftED0EdB