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Mashup Score: 2JCI - Itaconate suppresses atherosclerosis by activating a Nrf2-dependent anti-inflammatory response in macrophages in mice - 6 month(s) ago
ResearchIn-Press PreviewCardiologyInflammation Open Access | 10.1172/JCI173034 Yanling Zhang,2 Ryan A. Frieler,3 Anthony Andren,3 Sherri C. Wood,1 Daniel J. Tyrrell,5 Peter Sajjakulnukit,3 Jane C. Deng,6 Costas A. Lyssiotis,3 Richard M. Mortensen,3 Morgan Salmon,7 and Daniel R. Goldstein1 1Department…
Source: www.jci.orgCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 8Cardiovascular Aging: Spotlight on Mitochondria | American Journal of Physiology-Heart and Circulatory Physiology - 6 month(s) ago
Mitochondria are cellular organelles critical for ATP production and are particularly relevant to cardiovascular diseases including heart failure, atherosclerosis, ischemia reperfusion injury, and cardiomyopathies. With advancing age, even in the absence of clinical disease, mitochondrial homeostasis becomes disrupted (e.g. redox balance, mitochondrial DNA damage, oxidative metabolism, and mitochondrial quality control). Mitochondrial dysregulation leads to the accumulation of damaged and dysfunctional mitochondria, producing excessive reactive oxygen species and perpetuating mitochondrial dysfunction. Additionally, mitochondrial DNA, cardiolipin, and N-formyl peptides are potent activators of cell-intrinsic and extrinsic inflammatory pathways. These age-related mitochondrial changes contribute to development of cardiovascular diseases. This review covers the impact of aging on mitochondria and links these mechanisms to therapeutic implications for age-associated cardiovascular disease
Source: journals.physiology.orgCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 1Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice - PubMed - 6 month(s) ago
Aging is a strong risk factor for atherosclerosis and induces accumulation of memory CD8+ T cells in mice and humans. Biological changes that occur with aging lead to enhanced atherosclerosis, yet the role of aging on CD8+ T cells during atherogenesis is unclear. In this study, …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 2Considerations for reproducible omics in aging research - Nature Aging - 11 month(s) ago
High-throughput analysis of cellular landscapes is an important tool to decipher the molecular mechanisms driving aging and disease. Here, Singh and Benayoun discuss key considerations in the design and analysis of omic data to gain robust and reproducible insights into the aging process.
Source: NatureCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 2
The University of Redlands Women’s Tennis team had to fight their way back from a 2-1 deficit Tuesday afternoon against No. 39 Chapman University sweeping singles to pull off the 7-2 win inside the Verdieck Tennis Center.
Source: RedlandsCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 2Implications of and potential solutions for the weekend effect in heart transplantation - 1 year(s) ago
Donor-recipient matching is a complex decision process requiring the integration of multiple factors and a holistic view of the situation from both the donor and recipient perspectives. Donor/recipient sizes, ages, comorbidities, travel distances, anticipated ischemic times, studies on the donor organ, and other metrics must all be combined by transplant clinicians into a single decision to…
Categories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 6Immune mechanisms of cardiac aging - 1 year(s) ago
Immune mechanisms of cardiac aging
Source: cardiovascularaging.comCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 6JCI - Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis - 1 year(s) ago
Research ArticleCardiology Open Access | 10.1172/JCI158788 Daniel J. Tyrrell,4 Alexi Vasbinder,4 Changli Wei,5 Feriel Presswalla,4 Hui Wang,4 Pennelope Blakely,4 Ayse Bilge Ozel,6 Sarah Graham,6 Grace H. Holton,4 Joseph Dowsett,7 Akl C. Fahed,3 Kingsley-Michael Amadi,4 Grace K. Erne,4…
Source: www.jci.orgCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 6Million Dollar Match: Make 2X the Impact - 1 year(s) ago
Time is running out to give and get your tax-deductible gift MATCHED! Give now and every dollar you donate will DOUBLE to help save lives.This incredible $1,000,000 match opportunity is made possible by Julie & Don Antonucci, Dr. Richard Shemin & Susan Shemin, and Beverly A. Grant.
Source: American Heart AssociationCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 1
The durability of the immune response following the 3-dose BNT162b2 vaccination is unknown. The complexity of the situation is enhanced by the threat that highly transmissible variants may further accelerate the decline in the protection afforded by mRNA vaccines.
Categories: Cardiologists, Latest HeadlinesTweet
Please check out our latest article at @jclinicalinvest https://t.co/PRR9PYy1HD on #itaconate + #atherosclerosis @UMichMedSchool @umichCVC @umichmedicine @UABPathology @UMIntMed @UMMicroImmuno