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    Immunological injury to the allograft, specifically by antibodies to de novo donor specific human leukocyte antigen (dnDSA) and antibody mediated injury and rejection are the major limitations to graft survival after heart transplantation (HT). As such, our approach to allosensitization remains limited by the inability of contemporaneous immunoassays to unravel pathogenic potential of dnDSA….

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    • Read the article on HLA sensitization: Up to 30% HT recipients develop dnDSA. DSA against class II HLA predominate (>50%), followed by DSA to both class I & II HLA (up to 30%), while isolated class I HLA DSA are less frequent (<20%). @davebaran πŸ”—:https://t.co/AdOuXKdA5m

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    Evidence on characteristics and outcomes of patients undergoing heart transplantation for coronavirus disease 2019 (COVID-19) associated cardiomyopathy is limited to case reports. Of all 6,332 patients aged β‰₯18 years undergoing heart transplantation from July 2020 through May 2022 in the United Network for Organ Sharing database, 12 (0.2%) patients had COVID-19 myocarditis and 98 (1.6%) patients…

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    • Heart transplantation πŸ«€ is rarely performed on patients with COVID-19 cardiomyopathy, accounting for 0.2% of transplant practice in the USA based on UNOS data, yet early outcomes appear favorable in select patients. @DEmersonMD πŸ”—: https://t.co/0YkcXa8x0q

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    After being pioneered in South Africa,1 HIV donor-positive to recipient-positive (D+/R+) abdominal organ transplantation has been performed in the United States under research protocols pursuant to the HIV Organ Policy Equity (HOPE) Act.2,3 However, center volume requirements have until now precluded thoracic transplantation. We report the 90-day survival of the world’s first HIV D+/R+ heart…

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    • World’s first HIV-positive to HIV-positive #hearttransplant has been successfully performed @MonteHeart. @Gracedan10_99 @YoramPuiusMD πŸ”—: https://t.co/sQFBdpf9GW