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Mashup Score: 6Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine - Nature Communications - 2 year(s) ago
The authors have previously demonstrated the neutralising capacity of their nanoparticle vaccine, as well as showing protection of non-human primates from SARS-CoV-2 WA-1 infection. In this work, they investigate the ability of their vaccine candidate to neutralise SARS-CoV-2 variants of concern, and protect animals from other sarbecoviruses.
Source: NatureCategories: Infectious Disease, Latest HeadlinesTweet
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Mashup Score: 4Postdoctoral Research Associate - 2 year(s) ago
The person to fill this position will be part of a team performing highly relevant translational research whose ultimate goal is to develop new technologies for broadly active coronavirus vaccination. We aim to develop vaccines against coronavirus that we know about today and those that emerge in the future. The candidate will interact with both academic and industrial partners to achieve our…
Source: unc.peopleadmin.comCategories: Infectious Disease, Latest HeadlinesTweet-
#Vaccines #postdoc #job posting https://t.co/vuU9ojwgza
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We are looking for Postdocs to study RNA viral pathogenesis, vaccines and therapeutics @UNCpublichealth #jobs #postdocjobs #coronavirus #SARSCoV2 #COVID19 https://t.co/vuU9ojwgza https://t.co/BZKFp4PBTO
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Mashup Score: 0Postdoctoral Research Associate - 2 year(s) ago
The person to fill this position will be part of a team performing highly relevant translational research whose ultimate goal is to develop broadly active antiviral therapies. We aim to develop antivirals against coronavirus that we know about today and those that emerge in the future. The candidate will interact with both academic and industrial partners to achieve our goals. We are seeking…
Source: unc.peopleadmin.comCategories: Infectious Disease, Latest HeadlinesTweet-
#antivirals #postdoc #job posting https://t.co/JZbphIFlZG
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Mashup Score: 1Postdoctoral Research Associate - 2 year(s) ago
The person to fill this position will be an essential part of a team performing highly relevant translational research whose ultimate goal is to better understand the molecular mechanisms of coronavirus pathogenesis and to develop broadly active vaccines and antiviral therapies to prevent and stop infection. We aim to develop medical counter measures against coronavirus that we know about today…
Source: unc.peopleadmin.comCategories: Infectious Disease, Latest HeadlinesTweet-
RT @timothysheahan: Fun! #postdocs on #coronavirus #pathogenesis and #antivirals apply here https://t.co/usDHjsGfM0
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Mashup Score: 12A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies - 2 year(s) ago
COVID-19 survivors develop post-acute sequelae of SARS-CoV-2 (PASC), but the mechanistic basis of PASC-associated lung abnormalities suffers from a lack of longitudinal samples. Mouse-adapted SARS-CoV-2 MA10 produces an acute respiratory distress syndrome (ARDS) in mice similar to humans. To investigate PASC pathogenesis, studies of MA10-infected mice were extended from acute disease through…
Source: bioRxivCategories: Infectious Disease, Latest HeadlinesTweet-
We are excited to share our latest work on SARS-CoV-2 pathophysiology - A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies. https://t.co/OMVLdk3khE
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Mashup Score: 5SRC Prospective Member Recruitment Letter 2022.pdf - 2 year(s) agoSource: Google DocsCategories: Infectious Disease, Latest HeadlinesTweet
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NC Science, Math, and Engineering Professionals and Trainees: if you are interested in an opportunity that will help engage K12 students in STEM research, please consider volunteering for the NC Science and Engineering Fair Scientific Review Committee: https://t.co/IL0p5kAQj3 https://t.co/hCzsm5TglX
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Mashup Score: 9Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine - 2 year(s) ago
Coronavirus vaccines that are highly effective against SARS-CoV-2 variants are needed to control the current pandemic. We previously reported a receptor-binding domain (RBD) sortase A-conjugated ferritin nanoparticle (RBD-scNP) vaccine that induced neutralizing antibodies against SARS-CoV-2 and pre-emergent sarbecoviruses and protected monkeys from SARS-CoV-2 WA-1 infection. Here, we demonstrate…
Source: bioRxivCategories: Infectious Disease, Latest HeadlinesTweet-
Our preprint with the @lab_haynes and @Dapeng_LI is out. @David_RMartinez and @aschaefe29 led this from our group and tested the breadth of a #universal #SARSCoV2 vaccine that protected macaques and mice against all tested variants and SARS-like viruses. https://t.co/bbC2k8kFDy
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Mashup Score: 61A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice - 2 year(s) ago
The monoclonal antibody, DH1047, broadly protects in vivo against preemergent bat SARS-related viruses, SARS-CoV, and SARS-CoV-2 variants.
Source: Science Translational MedicineCategories: Infectious Disease, Latest HeadlinesTweet-
Elated to share that our paper was selected as the cover of @ScienceTM ! Thanks to @aschaefe29 @sophie_gobeil and @Dapeng_LI @priyam2021 for the collaboration. But the MVP to thank is the artist beneath the cover: @FalconieriV ! https://t.co/tqJJc1sekw @UNCpublichealth https://t.co/N1kEJAyQnc
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We are happy to share that our paper led by @David_RMartinez @aschaefe29 @sophie_gobeil @Dapeng_LI was selected as the cover of @ScienceTM ! Our paper is linked here as well. https://t.co/2eKSdiJZIn https://t.co/jbCL2Uy8aP
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Mashup Score: 5Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines - 3 year(s) ago
A clinical stage multivalent SARS-CoV-2 spike receptor-binding domain nanoparticle vaccine (RBD-NP) is protective in mice after a single immunization and elicits strong antibody responses across circulating mutants and broader sarbecoviruses. Multivalent sarbecovirus RBD-NPs can heterotypic protection as serve as a broad therapeutic against coronaviruses.
Source: CellCategories: Infectious Disease, Latest HeadlinesTweet-
We are happy to be a part of this #pansarbecovirus vaccine with the @veeslerlab just out in Cell. Great work from our group by @aschaefe29 @SarahRLeist @David_RMartinez and @timothysheahan . @UNCpublichealth @CellCellPress https://t.co/TauEIMd485
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Mashup Score: 5
mRNA vaccines that express chimeric spike protein protect mice against epidemic, zoonotic, and pandemic SARS-like viruses.
Source: ScienceCategories: Infectious Disease, Latest HeadlinesTweet-
We have also demonstrated #pansarbecovirus protective vaccines with @David_RMartinez and @aschaefe29 in our Science paper: https://t.co/lFd9Th1Vm1
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Our collaborative universal vaccine study is out in @NatureComms. These ferritin nanoparticle RBD vaccines protect monkeys against #SARS2 #Beta #Delta and protect mice against #SARSCoV and bat CoVs. Led by @David_RMartinez and @aschaefe29 from our group. https://t.co/Lyh1P9UQNt