Hwang et al. identify TRMT1L as the elusive methyltransferase responsible for catalyzing the m22G modification at position 27 on tyrosine tRNA. TRMT1L is also crucial for maintaining acp3U and D modifications on select tRNAs, and its depletion reduces tyrosine tRNA stability, global translation efficiency, and cell survival under oxidative stress.
ApoE2 and ApoE Christchurch variants are defective in LDLR binding, thus reducing the uptake of ApoE and associated lipid cargoes. LDLR-mediated internalization and endolysosomal delivery…
Khalatyan et al. show that poxvirus protein synthesis becomes dependent on 40S and 60S subunit proteins that are normally dispensable for most cellular mRNAs. RACK1 facilitates…
It is important for pharmacists to understand what RSV is, who is most affected by it, and what options are out there to prevent serious…
Predatory or “pseudo” journals can endanger the public by facilitating the dissemination of unvetted and fraudulent health information. Their deceptive practices also harm authors, their…
Molecular characterization of MPXV highlights two patterns of transmission contributing to the source of mpox cases in DRC: the traditional paradigm of zoonotic spillover, with…
Sun et al. resolved the structure of EBV gp350 in complex with the B cell receptor CR2. By identifying key residues on the glycan-free interface, they…
Depression and cardiovascular disease are often linked, with research showing inflammation is common for the 2 disease states.
Objective Babies born between 27+0 and 31+6 weeks of gestation contribute substantially towards infant mortality and morbidity. In England, their care is delivered in maternity…
The advisory emphasizes the need for a comprehensive approach to reducing alcohol-related cancer by combining prevention, education, and treatment to improve public health outcomes.
Corbit et al. studied patterns of activity in corticostriatal circuits during naturally occurring complex behavior in mice. In contrast to models in which cortex leads striatum,…
