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Mashup Score: 15
Background: Newer diabetes medications may have beneficial effects on mortality, cardiovascular outcomes, and renal outcomes. Purpose: To evaluate the effectiveness, comparative effectiveness, and harms of sodium–glucose cotransporter-2 (SGLT2) inhibitors, glucagon-like peptide-1 (GLP1) agonists, dipeptidyl peptidase-4 (DPP4) inhibitors, and long-acting insulins as monotherapy or combination therapy in adults with type 2 diabetes mellitus (T2DM). Data Sources: MEDLINE and EMBASE for randomized controlled trials (RCTs) published from 2010 through January 2023. Study Selection: RCTs lasting at least 52 weeks that included at least 500 adults with T2DM receiving eligible medications and reported any outcomes of interest. Data Extraction: Data were abstracted by 1 reviewer and verified by a second. Independent, dual assessments of risk of bias and certainty of evidence (CoE) were done. Data Synthesis: A total of 130 publications from 84 RCTs were identified. CoE was appraised using GRADE (
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Mashup Score: 0Annals of Internal Medicine - 15 hour(s) ago
Can’t sign in? Forgot your password? If the address matches an existing account you will receive an email with instructions to reset your password. Can’t sign in? Forgot your username? Congratulations to Nadia Jul iana Proa ñ os, MD, MSc, winner of the 2023 Annals Personae prize. Dr. Jain’s photograph was published on the cover of the March 2024 issue (vol. 177, no. 3), and appears
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Mashup Score: 3
Dr. Mom explores the challenges and ups and downs of juggling life as a hospitalist and mother. The feature appears quarterly in Annals Graphic Medicine at Annals.org.
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Mashup Score: 1
Background: The U.S. antibiotic market failure has threatened future innovation and supply. Understanding when and why clinicians underutilize recently approved gram-negative antibiotics might help prioritize the patient in future antibiotic development and potential market entry rewards. Objective: To determine use patterns of recently U.S. Food and Drug Administration (FDA)-approved gram-negative antibiotics (ceftazidime–avibactam, ceftolozane–tazobactam, meropenem–vaborbactam, plazomicin, eravacycline, imipenem–relebactam–cilastatin, and cefiderocol) and identify factors associated with their preferential use (over traditional generic agents) in patients with gram-negative infections due to pathogens displaying difficult-to-treat resistance (DTR; that is, resistance to all first-line antibiotics). Design: Retrospective cohort. Setting: 619 U.S. hospitals. Participants: Adult inpatients. Measurements: Quarterly percentage change in antibiotic use was calculated using weighted linear
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Mashup Score: 6Excessive Alcohol Use and Alcohol Use Disorders: A Policy Brief of the American College of Physicians | Annals of Internal Medicine - 2 day(s) ago
Alcohol is used by more people in the United States than tobacco, electronic nicotine delivery systems, or illicit drugs. Several health conditions, including cancer, cardiovascular disease, and liver disease, are associated with excessive alcohol use and alcohol use disorder. Nearly 30 million people aged 12 years or older in the United States reported past-year alcohol use disorder in 2022, but—despite its prevalence—alcohol use disorder is undertreated. In this policy brief, the American College of Physicians outlines the health effects of excessive alcohol use and alcohol use disorder, calls for policy changes to increase the availability of treatment of alcohol use disorder and excessive alcohol use, and recommends alcohol-related public health interventions.
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Mashup Score: 3Historical Redlining and Present-Day Nonsuicide Firearm Fatalities | Annals of Internal Medicine - 2 day(s) ago
Background: Redlining began in the 1930s with the Home Owners’ Loan Corporation (HOLC); this discriminatory practice limited mortgage availability and reinforced concentrated poverty that still exists today. It is important to understand the potential health implications of this federally sanctioned segregation. Objective: To examine the relationship between historical redlining policies and present-day nonsuicide firearm fatalities. Design: Maps from the HOLC were overlaid with incidence of nonsuicide firearm fatalities from 2014 to 2022. A multilevel negative binomial regression model tested the association between modern-day firearm fatalities and HOLC historical grading (A [“best”] to D [“hazardous”]), controlling for year, HOLC area–level demographics, and state-level factors as fixed effects and a random intercept for city. Incidence rates (IRs) per 100 000 persons, incidence rate ratios (IRRs), and adjusted IRRs (aIRRs) for each HOLC grade were estimated using A-rated areas as t
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Mashup Score: 4Annals of Internal Medicine - 3 day(s) ago
Anders Hviid, DrMedSci, J ø rgen Vinsl ø v Hansen, PhD, Morten Frisch, DrMedSci, and Mads Melbye, DrMedSci Amir Qaseem, MD, PhD, MHA, Timothy J. Wilt, MD, MPH, Robert M. McLean, MD, and Mary Ann Forciea, MD, for the Clinical Guidelines Committee of the American College of Physicians* Amir Qaseem, MD, PhD, MHA, Lauri A. Hicks, DO, Itziar Etxeandia-Ikobaltzeta, PharmD, Tatyana Shamliyan, MD, MS, and Thomas G. Cooney, MD, for the Clinical Guidelines Committee of the American College of Physicia ns
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Authors provided insight into 3 breaking news research articles during a live scientific plenary session at #IM2024. Read about time-restricted eating, next-gen #antibiotics, and @ACPIMPhysicians guideline on Type 2 #diabetes https://t.co/MQNtLKA6hO. @NMaruthur @SameerKadri12 https://t.co/9lyefJA1Gs
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Mashup Score: 0Magician, With Parkinson’s | Annals of Internal Medicine - 3 day(s) ago
Can’t sign in? Forgot your password? If the address matches an existing acc ount you will receive an email with instructions to reset your password. Can’t sign in? Forgot your username? First, there was a slowness to his sleight of hand, A barely perceptible tremor. His voice, melodic As an opera singer’s aria, grew raspy and hoarse, There. He kept clearing his throat, gargling with Aloe and cherry liqueurs. He fumbled with the Buttons on his Royal Oxford shirts, had trouble Lacing his shoes. And his
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Mashup Score: 2Low-Value Care: A Multilayer Problem Requiring Multilayer Solutions | Annals of Internal Medicine - 3 day(s) ago
In their article, Dindinger-Hill and colleagues study what happens to physician use of 2 low-value services, prostate-specific antigen testing and mammography in Medicare beneficiaries aged 75 year…
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Mashup Score: 6Excessive Alcohol Use and Alcohol Use Disorders: A Policy Brief of the American College of Physicians | Annals of Internal Medicine - 4 day(s) ago
Alcohol is used by more people in the United States than tobacco, electronic nicotine delivery systems, or illicit drugs. Several health conditions, including cancer, cardiovascular disease, and liver disease, are associated with excessive alcohol use and alcohol use disorder. Nearly 30 million people aged 12 years or older in the United States reported past-year alcohol use disorder in 2022, but—despite its prevalence—alcohol use disorder is undertreated. In this policy brief, the American College of Physicians outlines the health effects of excessive alcohol use and alcohol use disorder, calls for policy changes to increase the availability of treatment of alcohol use disorder and excessive alcohol use, and recommends alcohol-related public health interventions.
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New review from @ACPIMPhysicians finds SGLT2 inhibitors & GLP1 agonists reduce mortality & cardiovascular events in adults with Type 2 Diabetes. Compared to usual care, they also lower CKD progression & heart failure hospitalizations: https://t.co/fiKd7K6fbN https://t.co/SLN9JMYMpx