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Mashup Score: 4Annals of Internal Medicine: Multimedia - 4 day(s) ago
Can’t sign in? Forgot your password? If the address matches an existing account you will receive an email with instructions to reset your password. Can’t sign in? Forgot your username? Other Multimedia based content for the Author Insight Videos and Graphical Abstracts are found in individual articles as they
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Mashup Score: 0Physician Jobs - ACP's Career Connection - 5 day(s) ago
ACP’s Career Connection offers the top jobs available in Physician. Search and apply to open positions or post jobs on ACP’s Career Connection now.
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Mashup Score: 148
Background: No studies have reported the long-term outcomes of initiating sodium–glucose cotransporter-2 inhibitors (SGLT2is) in patients with estimated glomerular filtration rates less than 20 mL/min/1.73 m2 to predialysis. Objective: To compare the risk for dialysis, cardiovascular events, and death between SGLT2i users and nonusers in patients with type 2 diabetes (T2D) and stage 5 chronic kidney disease (CKD). Design: Target trial emulation study. Setting: Taiwan’s National Health Insurance Research Database (NHIRD). Participants: By applying sequential target trial emulation principle, 23 854 SGLT2i users and 23 892 SGLT2i nonusers were selected from the NHIRD for patients with T2D and stage 5 CKD from 1 May 2016 to 31 October 2021. Measurements: Conditional Cox proportional hazards models were used to compare the risks for dialysis, hospitalization for heart failure, acute myocardial infarction (AMI), diabetic ketoacidosis (DKA), acute kidney injury (AKI), and all-cause mortality
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Mashup Score: 4
In May 2023, the U.S. Preventive Services Task Force (USPSTF) posted a new draft recommendation for breast cancer screening, recommending mammography screening for women aged 40 to 74 years. The pr…
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Mashup Score: 4
Under the Inflation Reduction Act, Medicare will be able to negotiate prices for a limited number of high-cost prescription drugs. This article describes a loophole in the rules around the selectio…
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Mashup Score: 1
This Annals Video Summary discusses the following article: “The Benefits and Risks of Receiving Investigational Solid Tumor Drugs in Randomized Trials: A Systematic Review and Meta-analysis.”
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Mashup Score: 4
Under the Inflation Reduction Act, Medicare will be able to negotiate prices for a limited number of high-cost prescription drugs. This article describes a loophole in the rules around the selectio…
Source: www.acpjournals.orgCategories: General Medicine News, General Journals & SocietTweet
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Mashup Score: 14
Background: Albuminuria is a major risk factor for chronic kidney disease (CKD) progression, especially when categorized as moderate (30 to 300 mg/g) or severe (>300 mg/g). However, there are limited data on the prognostic value of albuminuria within the normoalbuminuric range (<30 mg/g) in persons with CKD. Objective: To estimate the increase in the cumulative incidence of CKD progression with greater baseline levels of albuminuria among persons with CKD who had normoalbuminuria (<30 mg/g). Design: Multicenter prospective cohort study. Setting: 7 U.S. clinical centers. Participants: 1629 participants meeting criteria from the CRIC (Chronic Renal Insufficiency Cohort) study with CKD (estimated glomerular filtration rate [eGFR], 20 to 70 mL/min/1.73 m2) and urine albumin–creatinine ratio (UACR) less than 30 mg/g. Measurements: Baseline spot urine albumin divided by spot urine creatinine to calculate UACR as the exposure variable. The 10-year adjusted cumulative incidences of CKD progres
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Mashup Score: 0Estimated Medicare Part D Savings From Generic Drugs With a Skinny Label | Annals of Internal Medicine - 7 day(s) ago
Can’t sign in? Forgot your password? If the address matches an existing account you will receive an email with instructions to reset your password. Can’t sign in? Forgot your username? View all available purchase options and get full access to this article. Walsh BS, Sarpatwari A, Rome BN, et al. Frequency of first generic drug approvals with “skinny labels” in the United States. JAMA Intern Med. 2021;181:995-997. [PMID: 33779681] doi: 10.1001/jamainternmed.2021.0484 Walsh BS, Kesselheim AS, Sarpatwari
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Mashup Score: 2
Background: Many patients participate in cancer trials to access new therapies. The extent to which new treatments produce clinical benefit for trial participants is unclear. Purpose: To estimate the progression-free survival (PFS) and overall survival (OS) advantage of assignment to experimental groups in randomized trials for 6 solid tumors. Data Sources: ClinicalTrials.gov was searched for trials of investigational drugs with results posted between 2017 and 2021. Study Selection: Investigational drugs were defined as those not yet having full approval from the U.S. Food and Drug Administration for the study indication. Trials were included if they were randomized and tested drugs or biologics. Data Extraction: Data extraction was completed by 2 independent reviewers. Data were pooled using a random-effects model. Data Synthesis: The sample included 128 trials comprising 141 comparisons of a new drug and a comparator. These comparisons included 47 050 patients. The pooled hazard rati
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