Tumor-initiating cells (TICs) are particularly efficient at evading detection and elimination by the human immune system. Recent data from Yang and collaborators demonstrate that – at least in preclinical hepatocellular carcinoma models – the immunological privilege of CD49f+ TICs can be limited by targeting CD155, resulting in restored sensitivity to immune checkpoint inhibitors.
Fu et al. discover a non-metabolic function of TKT in gliomas. Mechanistically, TKT undergoes translocation from the cytoplasm to the nucleus following chemotherapy. Nuclear TKT interacts…
During immune activation in Arabidopsis thaliana, the enhancer CORE PATTERN-INDUCED ENHANCER 35 (CPIE35) activates the transcription of WRKY15 by forming chromatin loops with the promoter…
As the population ages, neurovascular pathologies have become leading causes of death and disability. Santisteban and Iadecola review data showing that neurovascular aging not only…
Novak et al. show how Miro1 regulates mitochondrial transfer from the tumor microenvironment to mtDNA-deficient melanoma cells. The authors argue that delayed tumor formation observed in…
RAS/ERK signaling is necessary for oocyte development but is turned off during the oocyte-to-embryo transition across species. Baek et al. show that aberrant reactivation of ERK…
High-frequency tactile vibration signals captured by Pacinian corpuscles are routed to the lateral cortex of the inferior colliculus (LCIC), where they converge with auditory inputs…
Chronic hand eczema poses diagnostic and treatment challenges due to its multifaceted etiology. New therapies like JAK inhibitors offer hope.
Kim et al. observed that IL-21 regulates B cell fate in a context-dependent manner. IL-21 induces apoptosis in naive B cells but promotes proliferation of activated…
Intermittent fasting halts hair follicle regeneration by activating communication between adrenal glands and niche adipocytes, which in turn selectively induces apoptosis of hair follicle stem…
