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Mashup Score: 0Sphingosine Kinase 2 in Stromal Fibroblasts Creates a Hospitable Tumor Microenvironment in Breast Cancer - 1 year(s) ago
Sphingosine kinase 2 (SphK2) facilitates the activation of stromal fibroblasts to tumor-promoting cancer-associated fibroblasts by suppressing host p53 activity, revealing SphK2 as a potential target to reprogram the TME.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 3
Proteasome function is a necessary cellular component for endowing T cells with tumor killing capacity by mitigating translation attenuation resulting from the unfolded protein response induced by stress in the tumor microenvironment.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2
Proteasome function is a necessary cellular component for endowing T cells with tumor killing capacity by mitigating translation attenuation resulting from the unfolded protein response induced by stress in the tumor microenvironment.
Categories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 3Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance - Oncogene - 2 year(s) ago
The tumor microenvironment (TME) represents a milieu enabling cancer cells to develop malignant properties, while concerted interactions between cancer and stromal cells frequently shape an “activated/reprogramed” niche to accelerate pathological progression. Here we report that a soluble factor epiregulin (EREG) is produced by senescent stromal cells, which non-cell-autonomously develop the…
Source: NatureCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 0Targeting the Tumor Microenvironment | Cancer Research | American Association for Cancer Research - 2 year(s) ago
Cancer therapy has evolved beyond solely targeting cancer cells and now considers the tumor microenvironment (TME) as well. The cellular and acellular compon
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2Targeting the Tumor Microenvironment | Cancer Research | American Association for Cancer Research - 2 year(s) ago
Cancer therapy has evolved beyond solely targeting cancer cells and now considers the tumor microenvironment (TME) as well. The cellular and acellular compon
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Targeting the Tumor Microenvironment | Cancer Research | American Association for Cancer Research - 2 year(s) ago
Cancer therapy has evolved beyond solely targeting cancer cells and now considers the tumor microenvironment (TME) as well. The cellular and acellular compon
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Targeting the Tumor Microenvironment | Cancer Research | American Association for Cancer Research - 2 year(s) ago
Cancer therapy has evolved beyond solely targeting cancer cells and now considers the tumor microenvironment (TME) as well. The cellular and acellular compon
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2Spatial collagen stiffening promotes collective breast cancer cell invasion by reinforcing extracellular matrix alignment - Oncogene - 2 year(s) ago
The tumor micro-environment often contains stiff and irregular-bundled collagen fibers that are used by tumor cells to disseminate. It is still unclear how and to what extent, extracellular matrix (ECM) stiffness versus ECM bundle size and alignment dictate cancer cell invasion. Here, we have uncoupled Collagen-I bundling from stiffness by introducing inter-collagen crosslinks, combined with…
Source: NatureCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0Targeting the Tumor Microenvironment | Cancer Research | American Association for Cancer Research - 2 year(s) ago
Cancer therapy has evolved beyond solely targeting cancer cells and now considers the tumor microenvironment (TME) as well. The cellular and acellular compon
Source: aacrjournals.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
Weigel et al. identify sphingosine kinase 2 as a regulator of tumor-promoting cancer-associated #fibroblasts and as a potential target to reprogram the #tumormicroenvironment in #breastcancer. https://t.co/9Zw90IfM8z @VCUMassey https://t.co/qTijd9wywQ