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Mashup Score: 12Why some RNA drugs work better than others - 2 month(s) ago
Spinal muscular atrophy, or SMA, is the leading genetic cause of infant death. Less than a decade ago, Cold Spring Harbor Laboratory (CSHL) Professor Adrian Krainer showed this brutal disease can be treated …
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 7Cell Press Selections 2023_RNA sensing in immunity - 5 month(s) ago
RNA sensing in immunity
Source: info.cell.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 0Targeting the RNA-Binding Protein HuR in Cancer - 5 month(s) ago
Abstract. The RNA-binding protein human antigen R (HuR) is a well-established regulator of gene expression at the posttranscriptional level. Its dysregulation has been implicated in various human diseases, particularly cancer. In cancer, HuR is considered “active” when it shows increased subcellular localization in the cytoplasm, in addition to its normal nuclear localization. Cytoplasmic HuR plays a crucial role in stabilizing and enhancing the translation of prosurvival mRNAs that are involved in stress responses relevant to cancer progression, such as hypoxia, radiotherapy, and chemotherapy. In general, due to HuR’s abundance and function in cancer cells compared with normal cells, it is an appealing target for oncology research. Exploiting the principles underlying HuR’s role in tumorigenesis and resistance to stressors, targeting HuR has the potential for synergy with existing and novel oncologic therapies. This review aims to explore HuR’s role in homeostasis and cancer pathophys
Source: aacrjournals.orgCategories: General Medicine News, Onc News and JournalsTweet
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Mashup Score: 0Deep RNA-seq of male and female murine sensory neuron... : PAIN - 6 month(s) ago
nal profiles of multiple murine DRG populations in early and late pain states while considering sex. We have exploited currently available transgenics to label numerous subpopulations for fluorescent-activated cell sorting and subsequent transcriptomic analysis. Using bulk tissue samples, we are able to circumvent the issues of low transcript coverage and drop-outs seen with single-cell data sets. This increases our power to detect novel and even subtle changes in gene expression within neuronal subtypes and discuss sexual dimorphism at the neuronal subtype level. We have curated this resource into an accessible database for other researchers (https://livedataoxford.shinyapps.io/drg-directory/). We see both stereotyped and unique subtype signatures in injured states after nerve injury at both an early and late timepoint. Although all populations contribute to a general injury signature, subtype enrichment changes can also be seen. Within populations, there is not a strong intersection
Source: journals.lww.comCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 0
To mark World RNA Day, Isy Godfrey explores why cancer researchers are increasingly interested in RNA and considers the impact this essential molecule may have on the future cancer treatment landscape.
Source: www.icr.ac.ukCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 0
To mark World RNA Day, Isy Godfrey explores why cancer researchers are increasingly interested in RNA and considers the impact this essential molecule may have on the future cancer treatment landscape.
Source: www.icr.ac.ukCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 2Home - Cracking the Code: The Dawn of Nucleic Acid Medicines - 9 month(s) ago
The conference will discuss the development of nucleic acid medicines — both the recent clinical successes, and current and upcoming challenges. By bringing together academics in basic and translational research and their peers in thriving biotechnology companies and promising start-ups, the conference aims to foster dialog and to spearhead collaborations. The first day (October 17, 2023) will…
Source: www.cvent.comCategories: Future of Medicine, Latest HeadlinesTweet
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Mashup Score: 2RNA stability may play a role in prostate cancer - 9 month(s) ago
Mutations that affect RNA stability could influence prostate cancer outcomes and drug resistance, according to new work from scientists at Fred Hutchinson Cancer Center. The team developed innovative new techniques to assess the significance of patient-associated mutations in a key region of messenger RNA that helps regulate protein production and the RNA’s lifecycle.
Source: www.fredhutch.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 5RNA stability may play a role in prostate cancer - 9 month(s) ago
Mutations that affect RNA stability could influence prostate cancer outcomes and drug resistance, according to new work from scientists at Fred Hutchinson Cancer Center. The team developed innovative new techniques to assess the significance of patient-associated mutations in a key region of messenger RNA that helps regulate protein production and the RNA’s lifecycle.
Source: www.fredhutch.orgCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 5Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration - 9 month(s) ago
Nature Neuroscience – Global reduction of m6A leads to mRNA stabilization in ALS/FTD caused by C9ORF72 repeat expansion. m6A also regulates repeat RNA decay. Elevating m6A reduces RNA and dipeptide…
Source: www.nature.comCategories: General Medicine News, Latest HeadlinesTweet
Why some #RNA drugs work better than others @CSHL @NatureComms https://t.co/1q8EjhLuyr